Results 1 to 10 of about 8,962 (133)

Perspectives for pharmaceutical screening at XFEL sources using the example of Lassa virus endonuclease. [PDF]

Acta Crystallogr D Struct Biol
To facilitate structure‐based drug development, XFEL sources are of paramount interest. Here, we analyse the feasibility and data quality of serial femtosecond X‐ray crystallography compound screening at Linac Coherent Light Source and compare it with PETRA III synchrotron experiments.
Falke S, Reinke PYA, Rosenberg D, Fischer P, Meyer J, Galchenkova M, Tolstikova A, Mariani V, Senst JM, Lewe P, Witt S, Wagner A, Chapman HN, Hunter M, Günther S, Meents A.   +15 more
europepmc   +2 more sources

Development and validation of a pseudotyped virus neutralization assay for quantification of anti-Lassa virus neutralizing antibodies [PDF]

Frontiers in Immunology
BackgroundLassa virus is endemic in many West African countries and has significant epidemic/pandemic potential. The Coalition for Epidemic Preparedness Innovations (CEPI) Centralized Laboratory Network (CLN) is developing validated, harmonized methods ...
Edward T. Mee, Emma M. Bentley, Gathoni Kamuyu, Noemi Guerrini, Noemi Guerrini, Noemi Guerrini, Ali Azizi, Giada Mattiuzzo   +7 more
doaj   +2 more sources

Development of a broad-lineage Lassa virus rapid diagnostic test informed by the WHO REASSURED framework [PDF]

Journal of Clinical Microbiology
Lassa fever is a high-risk viral disease endemic to West Africa for which rapid and reliable diagnosis is essential for outbreak control. Here, we describe the development of a lateral flow-based rapid diagnostic test (RDT) targeting the Lassa virus ...
Hwachul Shin, Minji Lee, Myung-Min Choi, Jin-Won Kim, Hwajung Yi, Shannon Whitmer, Leanna Sayyad, Joel Montgomery, John Klena, Yoon-Seok Chung   +9 more
doaj   +2 more sources

Analysis of synonymous codon usage bias of Lassa virus [PDF]

Virus Research
Lassa virus genome consists of two single-stranded, negative-sense RNA segments that lie in the genus Arenavirus. The disease associated with the Lassa virus is distributed all over the world, with approximately 3,000,000–5,000,000 infections diagnosed ...
Siddiq Ur Rahman, Yikui Hu, Hassan Ur Rehman, May M. Alrashed, Kotb A. Attia, Ubaid Ullah, Huiying Liang   +6 more
doaj   +2 more sources

Systematics, Ecology, and Host Switching: Attributes Affecting Emergence of the Lassa Virus in Rodents across Western Africa

Viruses, 2020
Ever since it was established that rodents serve as reservoirs of the zoonotic Lassa virus (LASV), scientists have sought to answer the questions: which populations of rodents carry the virus?
Ayodeji Olayemi, Elisabeth Fichet-Calvet
doaj   +3 more sources

Expansion of CD8+ T cell population in Lassa virus survivors with low T cell precursor frequency reveals durable immune response in most survivors.

PLoS Neglected Tropical Diseases, 2022
IntroductionLassa virus is a priority pathogen for vaccine research and development, however the duration of cellular immunity and protection in Lassa fever (LF) survivors remains unclear.MethodsWe investigated Lassa virus specific CD8+ T cell responses ...
Stephanie M LaVergne, Saori Sakabe, Mambu Momoh, Lansana Kanneh, Nell Bond, Robert F Garry, Donald S Grant, Juan Carlos de la Torre, Michael B A Oldstone, John S Schieffelin, Brian M Sullivan   +10 more
doaj   +1 more source

Virus persistence after recovery from acute Lassa fever in Nigeria: a 2-year interim analysis of a prospective longitudinal cohort study

The Lancet Microbe, 2022
Summary: Background: There is anecdotal evidence for Lassa virus persistence in body fluids. We aimed to investigate various body fluids after recovery from acute Lassa fever, describe the dynamics of Lassa virus RNA load in seminal fluid, and assess ...
Anke Thielebein, PhD, Yemisi Ighodalo, MSc, Abubakar Taju, MD, Thomas Olokor, MSc, Racheal Omiunu, BSc, Rita Esumeh, MSc, Paulson Ebhodaghe, BSc, Anieno Ekanem, BSc, Ganiyu Igenegbale, MSc, Rosemary Giwa, BSc, Annick Renevey, PhD, Julia Hinzmann, Jonas Müller, Elisa Pallasch, Meike Pahlmann, PhD, Jeremie Guedj, PhD, Joy Nwatuzor, BSc, Oluwasola Femi Babatunde, BSc, Donatus I Adomeh, PhD, Danny Asogun, MD, Nosa Akpede, MD, Sylvanus Okogbenin, ProfMD, Stephan Günther, ProfMD, Lisa Oestereich, PhD, Sophie Duraffour, PhD, Ephraim Ogbaini-Emovon, MD   +25 more
doaj   +1 more source

A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Nature Communications, 2023
Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate.
Adam J. Ronk, Nicole M. Lloyd, Min Zhang, Caroline Atyeo, Hailee R. Perrett, Chad E. Mire, Kathryn M. Hastie, Rogier W. Sanders, Philip J. M. Brouwer, Erica Olmann Saphire, Andrew B. Ward, Thomas G. Ksiazek, Juan Carlos Alvarez Moreno, Harshwardhan M. Thaker, Galit Alter, Sunny Himansu, Andrea Carfi, Alexander Bukreyev   +17 more
doaj   +1 more source

Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol

Pathogens, 2020
Knowledge of the survival and stability of a pathogen is important for understanding its risk, reducing its transmission, and establishing control measures.
Sophie J Smither, Lin S Eastaugh, James S Findlay, Lyn M O’Brien, Mark S Lever   +4 more
doaj   +1 more source

Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades

Nature Communications, 2022
It is currently unknown how climate and land use changes could affect the endemic area of Lassa virus, a zoonotic pathogen responsible for Lassa fever.
Raphaëlle Klitting, Liana E. Kafetzopoulou, Wim Thiery, Gytis Dudas, Sophie Gryseels, Anjali Kotamarthi, Bram Vrancken, Karthik Gangavarapu, Mambu Momoh, John Demby Sandi, Augustine Goba, Foday Alhasan, Donald S. Grant, Sylvanus Okogbenin, Ephraim Ogbaini-Emovo, Robert F. Garry, Allison R. Smither, Mark Zeller, Matthias G. Pauthner, Michelle McGraw, Laura D. Hughes, Sophie Duraffour, Stephan Günther, Marc A. Suchard, Philippe Lemey, Kristian G. Andersen, Simon Dellicour   +26 more
doaj   +1 more source