Results 1 to 10 of about 17,001 (224)

Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: Lassa fever is a viral hemorrhagic fever endemic in West Africa. However, none of the hospitals in the endemic areas of Nigeria has the capacity to perform Lassa virus diagnostics.
Danny A Asogun, Donatus I Adomeh, Jacqueline Ehimuan, Ikponmwonsa Odia, Meike Hass, Martin Gabriel, Stephan Olschläger, Beate Becker-Ziaja, Onikepe Folarin, Eric Phelan, Philomena E Ehiane, Veritas E Ifeh, Eghosasere A Uyigue, Yemisi T Oladapo, Ekene B Muoebonam, Osagie Osunde, Andrew Dongo, Peter O Okokhere, Sylvanus A Okogbenin, Mojeed Momoh, Sylvester O Alikah, Odigie C Akhuemokhan, Peter Imomeh, Maxy A C Odike, Stephen Gire, Kristian Andersen, Pardis C Sabeti, Christian T Happi, George O Akpede, Stephan Günther   +29 more
doaj   +4 more sources

Detection of Lassa Virus, Mali

Emerging Infectious Diseases, 2010
To determine whether Lassa virus was circulating in southern Mali, we tested samples from small mammals from 3 villages, including Soromba, where in 2009 a British citizen probably contracted a lethal Lassa virus infection.
David Safronetz, Job E. Lopez, Nafomon Sogoba, Sékou F. Traore’, Sandra J. Raffel, Elizabeth R. Fischer, Hideki Ebihara, Luis M. Branco, Robert F. Garry, Tom G. Schwan, Heinz Feldmann   +10 more
doaj   +3 more sources

Analysis of synonymous codon usage bias of Lassa virus [PDF]

Virus Research
Lassa virus genome consists of two single-stranded, negative-sense RNA segments that lie in the genus Arenavirus. The disease associated with the Lassa virus is distributed all over the world, with approximately 3,000,000–5,000,000 infections diagnosed ...
Siddiq Ur Rahman, Yikui Hu, Hassan Ur Rehman, May M. Alrashed, Kotb A. Attia, Ubaid Ullah, Huiying Liang   +6 more
doaj   +2 more sources

Lassa virus protein-protein interactions as mediators of Lassa fever pathogenesis. [PDF]

Virol J
Abstract Viral hemorrhagic Lassa fever (LF), caused by Lassa virus (LASV), is a significant public health concern endemic in West Africa with high morbidity and mortality rates, limited treatment options, and potential for international spread.
Jan S, Phadke KS, Lam VL, Branda SS, Johnson DM.   +4 more
europepmc   +4 more sources

Inter-Lineage Variation of Lassa Virus Glycoprotein Epitopes: A Challenge to Lassa Virus Vaccine Development [PDF]

Viruses, 2020
Lassa virus (LASV), which causes considerable morbidity and mortality annually, has a high genetic diversity across West Africa. LASV glycoprotein (GP) expresses this diversity, but most LASV vaccine candidates utilize only the Lineage IV LASV Josiah ...
Francis Ifedayo Ibukun
doaj   +3 more sources

Rodent control strategies and Lassa virus: some unexpected effects in Guinea, West Africa [PDF]

Emerging Microbes and Infections
The Natal multimammate mouse (Mastomys natalensis) is the host of Lassa mammarenavirus, causing Lassa haemorrhagic fever in West Africa. As there is currently no operational vaccine and therapeutic drugs are limited, we explored rodent control as an ...
Joachim Mariën, Mickaël Sage, Umaru Bangura, Alicia Lamé, Michel Koropogui, Toni Rieger, Barré Soropogui, Moussa Douno, N’Faly Magassouba, Elisabeth Fichet-Calvet   +9 more
doaj   +2 more sources

Expansion of CD8+ T cell population in Lassa virus survivors with low T cell precursor frequency reveals durable immune response in most survivors.

PLoS Neglected Tropical Diseases, 2022
IntroductionLassa virus is a priority pathogen for vaccine research and development, however the duration of cellular immunity and protection in Lassa fever (LF) survivors remains unclear.MethodsWe investigated Lassa virus specific CD8+ T cell responses ...
Stephanie M LaVergne, Saori Sakabe, Mambu Momoh, Lansana Kanneh, Nell Bond, Robert F Garry, Donald S Grant, Juan Carlos de la Torre, Michael B A Oldstone, John S Schieffelin, Brian M Sullivan   +10 more
doaj   +1 more source

A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Nature Communications, 2023
Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate.
Adam J. Ronk, Nicole M. Lloyd, Min Zhang, Caroline Atyeo, Hailee R. Perrett, Chad E. Mire, Kathryn M. Hastie, Rogier W. Sanders, Philip J. M. Brouwer, Erica Olmann Saphire, Andrew B. Ward, Thomas G. Ksiazek, Juan Carlos Alvarez Moreno, Harshwardhan M. Thaker, Galit Alter, Sunny Himansu, Andrea Carfi, Alexander Bukreyev   +17 more
doaj   +1 more source

Virus persistence after recovery from acute Lassa fever in Nigeria: a 2-year interim analysis of a prospective longitudinal cohort study

The Lancet Microbe, 2022
Summary: Background: There is anecdotal evidence for Lassa virus persistence in body fluids. We aimed to investigate various body fluids after recovery from acute Lassa fever, describe the dynamics of Lassa virus RNA load in seminal fluid, and assess ...
Anke Thielebein, PhD, Yemisi Ighodalo, MSc, Abubakar Taju, MD, Thomas Olokor, MSc, Racheal Omiunu, BSc, Rita Esumeh, MSc, Paulson Ebhodaghe, BSc, Anieno Ekanem, BSc, Ganiyu Igenegbale, MSc, Rosemary Giwa, BSc, Annick Renevey, PhD, Julia Hinzmann, Jonas Müller, Elisa Pallasch, Meike Pahlmann, PhD, Jeremie Guedj, PhD, Joy Nwatuzor, BSc, Oluwasola Femi Babatunde, BSc, Donatus I Adomeh, PhD, Danny Asogun, MD, Nosa Akpede, MD, Sylvanus Okogbenin, ProfMD, Stephan Günther, ProfMD, Lisa Oestereich, PhD, Sophie Duraffour, PhD, Ephraim Ogbaini-Emovon, MD   +25 more
doaj   +1 more source

Lassa Virus Treatment Options

Microorganisms, 2021
Lassa fever causes an approximate 5000 to 10,000 deaths annually in West Africa and cases have been imported into Europe and the Americas, challenging public health. Although Lassa virus was first described over 5 decades ago in 1969, no treatments or vaccines have been approved to treat or prevent infection.
Frederick Hansen, Michael A. Jarvis, Heinz Feldmann, Kyle Rosenke   +3 more
openaire   +3 more sources