Results 31 to 40 of about 1,049,804 (214)
Lassa Fever Encephalopathy: Lassa Virus in Cerebrospinal Fluid but Not in Serum [PDF]
The Journal of Infectious Diseases, 2001 The pathogenesis of neurologic complications of Lassa fever is poorly understood. A Nigerian patient had fever, disorientation, seizures, and blood-brain barrier dysfunction, and Lassa virus was found in cerebrospinal fluid (CSF) but not in serum.
S, Günther +9 more
openaire +2 more sources
Aseptic Meningitis Caused by Lassa Virus: Case Series Report
Case Reports in Neurological Medicine, 2016 The Lassa virus is known to cause disease in different organ systems of the human body, with varying clinical manifestations. The features of severe clinical disease may include bleeding and/or central nervous system manifestations.
Peter O. Okokhere +6 more
doaj +1 more source
Selection and Characterization of Single-Domain Antibodies for Detection of Lassa Nucleoprotein
Antibodies, 2020 Lassa virus is the etiologic agent of Lassa fever, an acute and often fatal illness endemic to West Africa. It is important to develop new reagents applicable either for the specific diagnosis or as improved therapeutics for the treatment of Lassa fever.
George P. Anderson +3 more
doaj +1 more source
Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants. [PDF]
PLoS Neglected Tropical Diseases, 2009 Proteolytic processing of the Lassa virus envelope glycoprotein precursor GP-C by the host proprotein convertase site 1 protease (S1P) is a prerequisite for the incorporation of the subunits GP-1 and GP-2 into viral particles and, hence, essential for ...
Anna Maisa +4 more
doaj +1 more source
Molecular confirmation of Lassa fever imported into Ghana
African Journal of Laboratory Medicine, 2016 Background: Recent reports have shown an expansion of Lassa virus from the area where it was first isolated in Nigeria to other areas of West Africa.
Joseph H.K. Bonney +11 more
doaj +1 more source
Immunobiology of Ebola and Lassa virus infections [PDF]
Nature Reviews Immunology, 2017 Two of the most important contemporary emerging viruses that affect human health in Africa are Ebola virus (EBOV) and Lassa virus (LASV). The 2013-2016 West African outbreak of EBOV was responsible for more than 11,000 deaths, primarily in Guinea, Sierra Leone and Liberia.
Joseph B, Prescott +5 more
openaire +2 more sources
Mutational Analysis of the Lassa Virus Promoter [PDF]
Journal of Virology, 2006 ABSTRACT The promoter sequences directing viral gene expression and genome replication of arenaviruses reside within the 3′ and 5′ termini of each RNA segment. The terminal 19 nucleotides at both ends are highly conserved among all arenavirus species and are almost completely complementary to each other. This study aimed at characterizing the
Meike, Hass +5 more
openaire +2 more sources
Molecular Therapy: Oncolytics, 2021 The difficulty of glioblastoma treatment makes it a good candidate for novel therapies, such as oncolytic viruses. Vesicular stomatitis virus expressing Lassa virus glycoprotein (Lassa-VSV) showed significant promise in animal models using established ...
Teddy E. Kim +8 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li +11 more
wiley +1 more source
PLoS Neglected Tropical Diseases, 2020 Lassa virus is a significant burden on human health throughout its endemic region in West Africa, with most human infections the result of spillover from the primary rodent reservoir of the virus, the natal multimammate mouse, M. natalensis.
Scott L Nuismer +10 more
doaj +1 more source