Results 31 to 40 of about 8,755 (175)

Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells

Molecular Therapy: Oncolytics, 2021
The difficulty of glioblastoma treatment makes it a good candidate for novel therapies, such as oncolytic viruses. Vesicular stomatitis virus expressing Lassa virus glycoprotein (Lassa-VSV) showed significant promise in animal models using established ...
Teddy E. Kim, Shelby Puckett, Kailong Zhang, Denise M. Herpai, David A. Ornelles, John N. Davis, Anthony N. van den Pol, Waldemar Debinski, Douglas S. Lyles   +8 more
doaj   +1 more source

A mouse model of mechanical stress injury to the basal ganglia using thermosensitive PNIPAM hydrogel for intracerebral hemorrhage research

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li, Yujie Chen, Rongsu Huang, Min Xia, Chao Mi, Yuan Tian, Peiwen Guo, Taotao Jin, Shilei Hao, Hua Feng, Yujie Chen, Zhi Chen   +11 more
wiley   +1 more source

Immunobiology of Ebola and Lassa virus infections [PDF]

Nature Reviews Immunology, 2017
Two of the most important contemporary emerging viruses that affect human health in Africa are Ebola virus (EBOV) and Lassa virus (LASV). The 2013-2016 West African outbreak of EBOV was responsible for more than 11,000 deaths, primarily in Guinea, Sierra Leone and Liberia.
Joseph B, Prescott, Andrea, Marzi, David, Safronetz, Shelly J, Robertson, Heinz, Feldmann, Sonja M, Best   +5 more
openaire   +2 more sources

Bayesian estimation of Lassa virus epidemiological parameters: Implications for spillover prevention using wildlife vaccination.

PLoS Neglected Tropical Diseases, 2020
Lassa virus is a significant burden on human health throughout its endemic region in West Africa, with most human infections the result of spillover from the primary rodent reservoir of the virus, the natal multimammate mouse, M. natalensis.
Scott L Nuismer, Christopher H Remien, Andrew J Basinski, Tanner Varrelman, Nathan Layman, Kyle Rosenke, Brian Bird, Michael Jarvis, Peter Barry, Patrick W Hanley, Elisabeth Fichet-Calvet   +10 more
doaj   +1 more source

Putting Rodents at the Center of One Health Programs: A Narrative Synthesis

Integrative Zoology, EarlyView.
Rodents link human, animal, and environmental health across diverse ecosystems. Rodent diversity underpins both zoonotic disease risk and ecosystem function. Environmental change reshapes rodent communities and spillover dynamics. Rodents act as reservoirs, amplifiers, and sentinels of emerging pathogens.
Steven R. Belmain
wiley   +1 more source

Mutational Analysis of the Lassa Virus Promoter [PDF]

Journal of Virology, 2006
ABSTRACT The promoter sequences directing viral gene expression and genome replication of arenaviruses reside within the 3′ and 5′ termini of each RNA segment. The terminal 19 nucleotides at both ends are highly conserved among all arenavirus species and are almost completely complementary to each other. This study aimed at characterizing the
Meike, Hass, Martina, Westerkofsky, Stefanie, Müller, Beate, Becker-Ziaja, Carola, Busch, Stephan, Günther   +5 more
openaire   +2 more sources

Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria. [PDF]

Emerg Microbes Infect
Identification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. To better characterize potential animal hosts of Lassa virus (LASV), we assessed domestic and non-domestic animals from ...
Happi AN, Ogunsanya OA, Ayinla AO, Sijuwola AE, Saibu FM, Akano K, Nwofoke C, Elias OT, Achonduh-Atijegbe O, Daodu RO, Adedokun OA, Adeyemo A, Ogundana KE, Lawal OZ, Parker E, Nosamiefan I, Okolie J, Parker ZF, McCauley MD, Eller LA, Lombardi K, Tiamiyu AB, Iroezindu M, Akinwale E, Njatou TLFA, Mebrahtu T, Broach E, Zuppe A, Prins P, Lay J, Amare M, Modjarrad K, Collins ND, Vasan S, Tucker C, Daye S, Happi CT.   +36 more
europepmc   +4 more sources

Wearable Electronic Monitoring of Vital Signs in Hospitalised Adults: A Nursing Focused Scoping Review of Clinical, Economic and Implementation Outcomes

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise evidence on wearable devices for continuous vital signs monitoring in adult hospital inpatients, focusing on clinical effectiveness, nursing perspectives, workflow impact, patient experience and resource implications. Design Scoping review.
Sian Myfanwy Shaw, Sophie Bethan Shaw, Gillian Janes   +2 more
wiley   +1 more source

Qualitative Assessment of One Health Operationalization at the Central Level and in Two Border Districts of Sierra Leone

Public Health Challenges, Volume 5, Issue 3, September 2026.
Implementation of the One Health approach in Sierra Leone was stronger at the central level than in districts and communities, where coordination, surveillance, workforce capacity, and funding were limited. Strengthening integrated systems and dedicated financing is essential for effective prevention and control of zoonotic disease threats.
Joseph Anderson Bunting‐Graden, Fatmata Sawaneh, Alhassan Mayei, Monya Konneh, Patrick Fatoma, Emmanuel Komba Finoh, Lily Kainwo, Wesen Konteh, Mukeh Kenneth Fahnbulleh, Klaere Heyden, Mohamed Alex Vandi, Foday Sahr, Adel Hussein Elduma Abdalla, Rashid Ansumana, Kinley Wangdi, Philip P. Mshelbwala   +15 more
wiley   +1 more source

Immunogenesis in Lassa fever and prospects for vaccine development

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Analysis of literature data on the structure of the Lassa virus genome and its strain diversity has shown that the molecular heterogeneity of strains is essential in the design of vaccines and evaluation of their efficacy, which is determined by the ...
Vladimir A. Markin
doaj   +1 more source