Results 31 to 40 of about 17,001 (224)

Immune Responses and Lassa Virus Infection [PDF]

Viruses, 2012
Lassa fever is a hemorrhagic fever endemic to West Africa and caused by Lassa virus, an Old World arenavirus. It may be fatal, but most patients recover from acute disease and some experience asymptomatic infection. The immune mechanisms associated with these different outcomes have not yet been fully elucidated, but considerable progress has recently ...
Russier, Marion, Pannetier, Delphine, Baize, Sylvain   +2 more
openaire   +4 more sources

Can clinical features predict Lassa virus positivity and outcome in children suspected of Lassa virus disease in a tertiary hospital, Southeast Nigeria?

Nigerian Journal of Paediatrics, 2021
Background: Lassa virus disease (LVD) is of public health concern in endemic countries of Africa. Majority of Lassa virus infections are asymptomatic while symptomatic cases can mimic other infections.
Orji Chito Maria-Lauretta, Onyire Benson Nnamdi , Chijioke Ogodo Ogeh   +2 more
doaj  

Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions. [PDF]

, 2008
The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks.
A.G. Sprecher, Anon., Baize, Basler, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Benjamin Jeffs, Bernard, Borchert, Bosio, Bosio, Boumandouki, Bray, Bray, Bray, Bray, Brummel-Ziedins, Bukreyev, Bwaka, CDC and WHO, Colebunders, Daddario-DiCaprio, Daniel G. Bausch, Dowell, Egbring, Emond, Enterlein, Feldmann, Formenty, Fourrier, Gear, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Gibbs, Gupta, Hensley, Hensley, Hensley, Hewlett, Hewlett, Hoenen, Hotchkiss, Huggins, Jahrling, Jahrling, Jahrling, Jeffs, Johnson, Jones, Jones, Khan, Ksiazek, Kudoyarova-Zubavichene, Larkin, Leroy, Leroy, Mahanty, Mahanty, Martin, Martini, Martini, Monath, Mupapa, Mupapa, Nikiforov, Oswald, Parrino, Pattyn, Paul Boumandouki, Peters, Peterson, Peterson, Pourrut, Reid, Rivers, Roberts, Rollin, Sanchez, Schnittler, Schuler, Smith, Spurgers, Stille, Sullivan, Sullivan, Swanepoel, Takada, Todorovitch, Towner, Warfield, Warfield, Warfield, Wilson, Zaki   +105 more
core   +2 more sources

Aseptic Meningitis Caused by Lassa Virus: Case Series Report

Case Reports in Neurological Medicine, 2016
The Lassa virus is known to cause disease in different organ systems of the human body, with varying clinical manifestations. The features of severe clinical disease may include bleeding and/or central nervous system manifestations.
Peter O. Okokhere, Idowu A. Bankole, Christopher O. Iruolagbe, Benard E. Muoebonam, Martha O. Okonofua, Simeon O. Dawodu, George O. Akpede   +6 more
doaj   +1 more source

Molecular confirmation and phylogeny of Lassa fever virus in Benin Republic 2014–2016

African Journal of Laboratory Medicine, 2019
Background: The changing epidemiology of the Lassa virus from endemic areas to other parts of West Africa has been reported. However, there have been no documented Lassa fever transmission chains in the Benin Republic.
Olumuyiwa B. Salu, Ayorinde B. James, Honoré S. Bankolé, Jijoho M. Agbla, Magloire Da Silva, Fernand Gbaguidi, Christian F. Loko, Sunday A. Omilabu   +7 more
doaj   +1 more source

Selection and Characterization of Single-Domain Antibodies for Detection of Lassa Nucleoprotein

Antibodies, 2020
Lassa virus is the etiologic agent of Lassa fever, an acute and often fatal illness endemic to West Africa. It is important to develop new reagents applicable either for the specific diagnosis or as improved therapeutics for the treatment of Lassa fever.
George P. Anderson, Jinny L. Liu, Lisa C. Shriver-Lake, Ellen R. Goldman   +3 more
doaj   +1 more source

Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants. [PDF]

PLoS Neglected Tropical Diseases, 2009
Proteolytic processing of the Lassa virus envelope glycoprotein precursor GP-C by the host proprotein convertase site 1 protease (S1P) is a prerequisite for the incorporation of the subunits GP-1 and GP-2 into viral particles and, hence, essential for ...
Anna Maisa, Ute Ströher, Hans-Dieter Klenk, Wolfgang Garten, Thomas Strecker   +4 more
doaj   +1 more source

Rapid bedside inactivation of Ebola virus for safe nucleic acid tests [PDF]

, 2016
Rapid bedside inactivation of Ebola virus would be a solution for the safety of medical and technical staff, risk containment, sample transport and high-throughput or rapid diagnostic testing during an outbreak.
Bragstad, Karoline, Dudman, Susanne Gjeruldsen, Fomsgaard, Anders, Karlberg, Helen, Kran, Anne Marte Bakken, Lindegren, Gunnel, Mirazimi, Ali, Rosenstierne, Maiken Wors\uf8e, Salata, Cristiano, Stoltz, Malin Lundahl   +9 more
core   +2 more sources

Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha. [PDF]

, 2019
Mastomys are the most widespread African rodent and carriers of various diseases such as the plague or Lassa virus. In addition, mastomys have rapidly gained a large number of mammary glands.
Aaron Hardin, Andersen, Bao, Besemer, Bickhart, Blanchette, Bolger, Bonwitt, Booker, Bourque, Camacho, Capra, Chapman, Chen, Chikhi, Chu, Colangelo, Dewey, Dierckxsens, Eblaghie, Grabherr, Hayssen, Heinz, Helfrich, Holloway, Holt, Jiang, Kannan, Kiełbasa, Kim, Kimberly A Nevonen, Kolmogorov, Korf, Krueger, Lecompte, Li, Li, Lok, Lowe, Lucia Carbone, MacManes, McLean, Modlin, Nadav Ahituv, Nagy, Nilsson, Närhi, Pennacchio, Pertea, Pimentel, Pollard, Sands, Schep, Scott, Siepel, Siepel, Simão, Smit, Snell, Song, Stanke, UniProt Consortium, Van der Auwera, Veltmaat, Veltmaat, Walter L Eckalbar   +65 more
core   +1 more source

Genetic Diversity among Lassa Virus Strains [PDF]

Journal of Virology, 2000
ABSTRACT The arenavirus Lassa virus causes Lassa fever, a viral hemorrhagic fever that is endemic in the countries of Nigeria, Sierra Leone, Liberia, and Guinea and perhaps elsewhere in West Africa. To determine the degree of genetic diversity among Lassa virus strains, partial nucleoprotein (NP) gene sequences were obtained from 54 strains ...
M D, Bowen, P E, Rollin, T G, Ksiazek, H L, Hustad, D G, Bausch, A H, Demby, M D, Bajani, C J, Peters, S T, Nichol   +8 more
openaire   +2 more sources