Development of a new vaccine for the prevention of Lassa fever.
PLoS Medicine, 2005 BACKGROUND: Recent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health challenge of emerging viruses.
Thomas W Geisbert +15 more
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Use of Favipiravir to Treat Lassa Virus Infection in Macaques
Emerging Infectious Diseases, 2018 Lassa virus, the cause of Lassa fever in humans, is endemic to West Africa. Treatment of Lassa fever is primarily supportive, although ribavirin has shown limited efficacy if administered early during infection.
Kyle Rosenke +12 more
doaj +1 more source
Environmental Persistence and Disinfection of Lassa Virus. [PDF]
Emerg Infect Dis, 2023 Abstract Lassa Fever, caused by Lassa virus (LASV), is endemic to West Africa, where approximately 300,000 illnesses and 5,000 deaths occur annually. LASV is primarily spread by infected multimammate rats via urine and fomites, highlighting the importance of understanding the environmental fate of LASV.
Shaffer M +5 more
europepmc +4 more sources
A GIS-BASED APPROACH TO RISK MAPPING OF LASSA FEVER OUTBREAK IN AKURE SOUTH LOCAL GOVERNMENT AREA, NIGERIA [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2022 Lassa fever is an acute viral illness, which is endemic in some counties in West Africa, including Guinea, Liberia, Sierra Leone and parts of Nigeria.
O. J. Ifejube +3 more
doaj +1 more source
Development and evaluation of antibody-capture immunoassays for detection of Lassa virus nucleoprotein-specific immunoglobulin M and G. [PDF]
PLoS Neglected Tropical Diseases, 2018 The classical method for detection of Lassa virus-specific antibodies is the immunofluorescence assay (IFA) using virus-infected cells as antigen.
Martin Gabriel +23 more
doaj +1 more source
Nigerian Journal of Paediatrics, 2021 Background: Lassa virus disease (LVD) is of public health concern in endemic countries of Africa. Majority of Lassa virus infections are asymptomatic while symptomatic cases can mimic other infections.
Orji Chito Maria-Lauretta +2 more
doaj
Molecular confirmation and phylogeny of Lassa fever virus in Benin Republic 2014–2016
African Journal of Laboratory Medicine, 2019 Background: The changing epidemiology of the Lassa virus from endemic areas to other parts of West Africa has been reported. However, there have been no documented Lassa fever transmission chains in the Benin Republic.
Olumuyiwa B. Salu +7 more
doaj +1 more source
Aseptic Meningitis Caused by Lassa Virus: Case Series Report
Case Reports in Neurological Medicine, 2016 The Lassa virus is known to cause disease in different organ systems of the human body, with varying clinical manifestations. The features of severe clinical disease may include bleeding and/or central nervous system manifestations.
Peter O. Okokhere +6 more
doaj +1 more source
Selection and Characterization of Single-Domain Antibodies for Detection of Lassa Nucleoprotein
Antibodies, 2020 Lassa virus is the etiologic agent of Lassa fever, an acute and often fatal illness endemic to West Africa. It is important to develop new reagents applicable either for the specific diagnosis or as improved therapeutics for the treatment of Lassa fever.
George P. Anderson +3 more
doaj +1 more source
Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants. [PDF]
PLoS Neglected Tropical Diseases, 2009 Proteolytic processing of the Lassa virus envelope glycoprotein precursor GP-C by the host proprotein convertase site 1 protease (S1P) is a prerequisite for the incorporation of the subunits GP-1 and GP-2 into viral particles and, hence, essential for ...
Anna Maisa +4 more
doaj +1 more source