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Vaccine Candidates against Arenavirus Infections
Vaccines, 2023 The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Rachel Reyna +2 more
exaly +5 more sources
Búsqueda de Hantavirus y Arenavirus en roedores de Villavicencio, Colombia
Revista Mvz Cordoba, 2022 Objetivo. Realizar una búsqueda de Hantavirus y Arenavirus en pequeños roedores y establecer su distribución espacial en diferentes ecosistemas del municipio de Villavicencio, departamento del Meta, Colombia. Materiales y método.
Andrés Camilo Rojas-Gulloso +5 more
doaj +5 more sources
Animal Models, Prophylaxis, and Therapeutics for Arenavirus Infections
Viruses, 2012 Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever.
Eric Vela
exaly +4 more sources
Challenges in predicting protein-protein interactions of understudied viruses: Arenavirus-human interactions. [PDF]
Comput Struct Biotechnol JUnderstanding protein-protein interactions (PPIs) between viruses and human proteins is crucial for uncovering infection mechanisms and identifying potential therapeutic targets. The ability to generalize PPI predictive models across understudied viruses
Sahni H +5 more
europepmc +2 more sources
MBio, 2022 The GP1 subcomponent of the New World arenavirus GP is a primary target of the neutralizing antibody response, which has been shown to be effective in the prevention and treatment of infection.
Weng M Ng +2 more
exaly +2 more sources
Molecular characterization of arenavirus defective viral genomes reveals sequence features associated with their formation [PDF]
Journal of VirologyDefective viral genomes (DVGs) are byproducts of replication that arise during infection with diverse RNA viruses and can impact virus infection and disease outcome.
Thomas Hoenen +5 more
doaj +2 more sources
Distinct Molecular Mechanisms of Host Immune Response Modulation by Arenavirus NP and Z Proteins
Viruses, 2020 Endemic to West Africa and South America, mammalian arenaviruses can cross the species barrier from their natural rodent hosts to humans, resulting in illnesses ranging from mild flu-like syndromes to severe and fatal haemorrhagic zoonoses. The increased
Robert J. Stott +2 more
doaj +2 more sources
Molecular organization of the New World arenavirus spike glycoprotein complex. [PDF]
Nat MicrobiolOf the multiple arenaviruses that cause haemorrhagic fevers in the Americas, all lack reliable therapeutic options, and only one has a vaccine. The arenavirus glycoprotein complex (GPC) binds cellular receptors and mediates pH-dependent fusion of viral ...
Mann CJ +8 more
europepmc +2 more sources
Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production
Frontiers in Microbiology, 2020 Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo +6 more
doaj +2 more sources
mBioArenaviruses, a family of negative-sense RNA viruses spread by rodents, are a leading cause of severe hemorrhagic fever in humans. Due to a paucity of antivirals and vaccines for arenaviruses, there is a need to identify new mechanisms for interfering ...
Matthew Hackbart, Carolina B. López
doaj +2 more sources