Results 1 to 10 of about 4,874 (174)

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, Volume 13, Issue 12, 27 February 2026.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Novel Oliveros-like Clade C Mammarenaviruses from Rodents in Argentina, 1990–2020

Viruses
Following an Argentine Hemorrhagic Fever (AHF) outbreak in the early 1990s, a rodent survey for Junín virus, a New World Clade B arenavirus, in endemic areas of Argentina was conducted.
Elizabeth Shedroff, Maria Laura Martin, Shannon L. M. Whitmer, Julia Brignone, Jorge B. Garcia, Carina Sen, Yael Nazar, Cintia Fabbri, Maria Morales-Betoulle, Jairo Mendez, Joel Montgomery, Maria Alejandra Morales, John D. Klena   +12 more
doaj   +1 more source

Land use gradients drive spatial variation in Lassa fever host communities in the Eastern Province of Sierra Leone

Journal of Animal Ecology, Volume 95, Issue 2, Page 296-312, February 2026.
As West Africa urbanises, the risk of Lassa fever may paradoxically decrease. We found the invasive house mouse, a dominant urban species, outcompetes and displaces the primary Lassa virus host. Considering these species interactions is critical for accurately predicting future zoonotic disease patterns.
David Simons, Rory Gibb, Umaru Bangura, Dianah Sondufu, Joyce Lamin, James Koninga, Momoh Foday, Mike Dawson, Joseph Lahai, Rashid Ansumana, Elisabeth Fichet‐Calvet, Deborah Watson‐Jones, Richard Kock, Kate E. Jones   +13 more
wiley   +1 more source

Targeting the apical domain of the transferrin receptor: Development of a new protein scaffold for cellular delivery

Protein Science, Volume 34, Issue 12, December 2025.
Abstract Human transferrin receptor 1 (TfR) is essential for cellular iron homeostasis by internalizing the iron carrier proteins transferrin and ferritin. It is also an entry point for various pathogens, such as South American hemorrhagic fever caused by arenaviruses and the malaria parasite Plasmodium vivax, which utilize TfR to gain access to cells.
Anuthariq Alikkam Veetil, Dick J. Sjöström, Cristian Iribarren, Camilla Mohlin, Elena Ambrosetti, Sinisa Bjelic   +5 more
wiley   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

Interaction of silver nanoparticles with Tacaribe virus

Journal of Nanobiotechnology, 2010
Background Silver nanoparticles possess many unique properties that make them attractive for use in biological applications. Recently they received attention when it was shown that 10 nm silver nanoparticles were bactericidal, which is promising in light
Speshock Janice L, Murdock Richard C, Braydich-Stolle Laura K, Schrand Amanda M, Hussain Saber M   +4 more
doaj   +1 more source

Ecologic Traits Analysis for Identifying Rodent Hosts for Arenavirus and Hepacivirus in the Americas

Biotropica, Volume 57, Issue 6, November 2025.
Over half of emerging human pathogens originate from wildlife, with rodents serving as key zoonotic hosts. This study used ecological trait‐based models to identify rodent traits associated with arenavirus and hepacivirus infections and detect potential host species across the Americas, our models achieve high predictive accuracy (AUC = 0.92–0.96).
María del Carmen Villalobos‐Segura, Oscar Rico‐Chavéz, Gerardo Suzán, Andrea Chaves   +3 more
wiley   +1 more source

The Biological Characteristics and Mouse Model of Lassa Virus From the First Imported Case in China

MedComm, Volume 6, Issue 8, August 2025.
This is the first case of Lassa fever being introduced to China. A strain of the Lineage IV LASV was successfully isolated, and genomic and mutation analysis were conducted. Infection models were constructed using BALB/c, C57BL/6, and AG129 mice, which were successfully established.
Yanan Zhou, Junbin Wang, Ranran Cao, Yun Yang, Yuliang Feng, Cong Tang, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang, Jiandong Shi, Kaiyun Ding, Longhai Yuan, Qing Dai, Xingping Zhao, Haiyan Li, Mengli Yang, Fangyu Luo, Fanli Zhu, Yong Zhang, Daoju Wu, Xiaorong Yang, Shuaiyao Lu, Qiangming Sun, Li Zhang, Youchun Wang   +25 more
wiley   +1 more source

Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells

Frontiers in Cellular and Infection Microbiology, 2018
An important step in the initiation of the innate immune response to virus infection is the recognition of non-self, viral RNA, including double-stranded RNA (dsRNA), by cytoplasmic pattern recognition receptors (PRRs).
Elizabeth J. Mateer, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Evaluating the Potential Adverse Effects of Favipiravir on Biochemical, Histopathological, and Spermatological Parameters in Male Rats' Testicular Tissue

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
ABSTRACT Favipiravir is a selective RNA polymerase inhibitor and a broad‐spectrum antiviral drug. Favipiravir reduces cell proliferation by inhibiting RNA transcription, particularly in rapidly proliferating cells such as spermatogonia. The aim of this study was to investigate the effects and mechanism of action of favipiravir (T‐705) on sperm quality ...
Ali Doğan Ömür, Gamze Uçak, Adem Kara, Elif Erbaş, Serkan Ali Akarsu, Seçkin Özkanlar, Nevra Aydemir Celep   +6 more
wiley   +1 more source