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Development of a Reverse Genetic System to Generate Recombinant Chimeric Tacaribe Virus that Expresses Junín Virus Glycoproteins [PDF]

Pathogens, 2020
Mammarenaviruses are enveloped and segmented negative-stranded RNA viruses that comprise several pathogenic members associated with severe human hemorrhagic fevers. Tacaribe virus (TCRV) is the prototype for the New World group of mammarenaviruses and is
Sabrina Foscaldi, María Eugenia Loureiro, Claudia Sepúlveda, Carlos Palacios, María Belén Forlenza, Nora López   +5 more
doaj   +8 more sources

Unraveling the mystery of Tacaribe virus [PDF]

mSphere
Tacaribe virus (TCRV) was first isolated in the mid-1950s from several Artibeus species bats in and around Port of Spain, Trinidad and Tobago. Since that time, debate has persisted whether artibeus bats serve as reservoir hosts of the virus or whether ...
Tony Schountz
doaj   +4 more sources

Interaction of silver nanoparticles with Tacaribe virus [PDF]

Journal of Nanobiotechnology, 2010
Background Silver nanoparticles possess many unique properties that make them attractive for use in biological applications. Recently they received attention when it was shown that 10 nm silver nanoparticles were bactericidal, which is promising in light
Speshock Janice L, Murdock Richard C, Braydich-Stolle Laura K, Schrand Amanda M, Hussain Saber M   +4 more
doaj   +5 more sources

Transcriptomic Signatures of Tacaribe Virus-Infected Jamaican Fruit Bats [PDF]

mSphere, 2017
Tacaribe virus (TCRV) is a mammalian arenavirus that was first isolated from artibeus bats in the 1950s. Subsequent experimental infection of Jamaican fruit bats (Artibeus jamaicensis) caused a disease similar to that of naturally infected bats. Although
Diana L. Gerrard, Ann Hawkinson, Tyler Sherman, Cassandra M. Modahl, Gretchen Hume, Corey L. Campbell, Tony Schountz, Seth Frietze   +7 more
doaj   +5 more sources

The Protein Kinase Receptor Modulates the Innate Immune Response against Tacaribe Virus [PDF]

Viruses, 2021
The New World (NW) mammarenavirus group includes several zoonotic highly pathogenic viruses, such as Junin (JUNV) or Machupo (MACV). Contrary to the Old World mammarenavirus group, these viruses are not able to completely suppress the innate immune ...
Hector Moreno, Stefan Kunz
doaj   +7 more sources

Development of Reverse Genetics for the Prototype New World Mammarenavirus Tacaribe Virus. [PDF]

Journal of Virology, 2020
To date, no Food and Drug Administration (FDA)-approved vaccines are available to combat hemorrhagic fever caused by mammarenavirus infections in humans. Treatment of mammarenavirus infections is limited to the off-label use of ribavirin, which is partially effective and associated with significant side effects.
Luis Martinez-Sobrido, Juan C de la Torre, Chengjin Ye   +2 more
exaly   +5 more sources

Discovery and biological confirmation of a highly divergent Tacaribe virus in metatranscriptomic data from neotropical bats [PDF]

mSphere
First isolated from neotropical fruit bats in Trinidad in 1956, Tacaribe virus (TCRV) has rarely been detected since. We searched for New World arenavirus reads in roughly 5.7 million sequencing runs available on public databases using Serratus.
Carlo Fischer, Murilo Henrique Anzolini Cassiano, William R. Thomas, Liliana M. Dávalos, Yolanda Leon, Jackeline Salazar, Stephen J. Rossiter, Andres Moreira-Soto, Jan Felix Drexler   +8 more
doaj   +4 more sources

Integrated molecular and metatranscriptomic evidence of Tacaribe virus and the brain virome profile of Molossus molossus bat sampled in Brazil [PDF]

Microbiology Spectrum
Tacaribe virus (TCRV), a New World arenavirus, is associated with neotropical frugivorous bats, particularly Artibeus spp., and is considered to have zoonotic potential.
Larissa Leão F. de Sousa, Rodrigo Lopes Sanz Duro, Raquel de Oliveira Vaz, Clara Lacerda de Athayde, Junior Olimpio Martins, Bruna Stefanie Silvério de Lima Slobosk, Mariana Dias Guilardi, Gustavo Cabral-Miranda, Edmilson Ferreira de Oliveira-Filho, Jan Felix Drexler, Luiz Mário Ramos Janini, Ricardo Durães-Carvalho   +11 more
doaj   +4 more sources

Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages. [PDF]

PLoS Neglected Tropical Diseases, 2011
The mechanisms underlying the development of disease during arenavirus infection are poorly understood. However, common to all hemorrhagic fever diseases is the involvement of macrophages as primary target cells, suggesting that the immune response in ...
Allison Groseth, Thomas Hoenen, Michaela Weber, Svenja Wolff, Astrid Herwig, Andreas Kaufmann, Stephan Becker   +6 more
doaj   +5 more sources

Complete genome sequence of Tacaribe virus. [PDF]

Arch Virol, 2020
AbstractTacaribe virus (TCRV) is the prototype of the New World arenaviruses (also known as TCRV serocomplex viruses). While TCRV is not itself a human pathogen, many closely related members of this group cause hemorrhagic fever, and thus TCRV has long served as an important BSL2 system for research into diverse areas of arenavirus biology.
Holzerland J, Leske A, Fénéant L, Garcin D, Kolakofsky D, Groseth A.   +5 more
europepmc   +5 more sources