Results 1 to 10 of about 2,667 (125)

Immunogenicity of recombinant vesicular stomatitis virus-vectored vaccines expressing the Machupo virus glycoprotein in different genome positions [PDF]

Journal of Virology
Recombinant vesicular stomatitis virus (rVSV) is a powerful vaccine platform that elicits durable cellular and humoral immune responses. rVSV vaccines have successfully been used for various hemorrhagic fever-causing viruses. Here, we create and evaluate
Rachel Erickson, Paul Bates
doaj   +2 more sources

Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex [PDF]

mBio
The spillover of New World (NW) arenaviruses from rodent reservoirs into human populations poses a continued risk to human health. NW arenaviruses present a glycoprotein (GP) complex on the envelope surface of the virion, which orchestrates host cell ...
Guido C. Paesen, Weng M. Ng, Simon Kimuda, Geoff Sutton, Katie J. Doores, Thomas A. Bowden   +5 more
doaj   +3 more sources

Genomic characterization of Sabiá virus in Brazil, 2019-2020: Implications for diagnostics, virus evolution, and receptor binding. [PDF]

PLoS Neglected Tropical Diseases
Between December 2019 and January 2020, two patients suspected of having severe yellow fever were admitted to a tertiary healthcare facility in São Paulo, Brazil, presenting with acute hemorrhagic syndrome and neurological alterations; both cases had ...
Ingra M Claro, Erika R Manuli, Camila A M da Silva, Thaís M Coletti, Philippe Lemey, Ana Catharina Nastri, Luciana Vilas Boas Casadio, Amaro Nunes Duarte-Neto, Joshua Quick, Camila M Romano, Charles Whittaker, Sarah C Hill, Carlos A Prete, Darlan S Candido, Filipe R R Moreira, Mariana S Ramundo, Ian Nunes Valença, Jaqueline G de Jesus, Flavia C S Sales, Mariana S Cunha, Juliana M Guerra, Maria Cassia Mendes-Correa, Tania R Tozetto-Mendoza, Marcilio Jorge Fumagalli, Yeh-Li Ho, Peter Simmonds, Weng M Ng, Thomas A Bowden, William M de Souza, Oliver G Pybus, Anna S Levin, Nicholas Loman, Ester C Sabino, Nuno R Faria   +33 more
doaj   +2 more sources

Climate-driven changes in zoonotic risk of arenaviral hemorrhagic fevers in South America [PDF]

npj Viruses
Climate change is expected to significantly alter the ecological dynamics of zoonotic diseases, yet its long-term impact on rodent-borne hemorrhagic fevers in South America remains poorly understood.
Pranav S. Kulkarni, Nuri Y. Flores-Pérez, Andie H. Jian, Brian H. Bird, Christine K. Johnson, Marcela Uhart, Pranav S. Pandit   +6 more
doaj   +2 more sources

Lassa and Mopeia viruses produce different RIG-I-activating RNA in the absence of a functional viral exoribonuclease domain [PDF]

Journal of Virology
All viruses of the genus Mammarenavirus possess an exoribonuclease (ExoN) domain in their nucleoproteins (NP). Through this domain, the NP efficiently prevents the activation of the interferon (IFN) response, presumably by degrading double-stranded RNA ...
Kodie Noy, Rachel Legendre, Séverine Croze, Valérie Najburg, Romane Fernandez, Julie Lucifora, Joel Lachuer, Sylvain Baize, Anastassia V. Komarova, Mathieu Mateo   +9 more
doaj   +2 more sources

A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses [PDF]

Viruses
The Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells.
Qinglin Kang, Gege Li, Yan Wu, Shaoyan Wang, Zhengshan Chen, Xiaodong Zai, Xiaoyan Pan, Rong Wang, Jiansheng Lu, Peng Du, Zhixin Yang, Xiangyang Chi, Gengfu Xiao, Junjie Xu   +13 more
doaj   +2 more sources

Role of Src family kinases Fyn and Lyn in arenavirus infection [PDF]

Journal of Virology
Arenaviruses encompass a diverse group of infectious agents, some of which, like Lassa virus (LASV), pose significant threats to global public health due to their acute virulence, while others, such as lymphocytic choriomeningitis virus (LCMV), are less ...
Wenting Mao, Minmin Zhou, Cheng Peng, Yi Wan, Li Li, Jialing Hu, Yang Liu, Yuan Peng, Chao Shan, Fei Deng, Zhiming Yuan, Wei Wang   +11 more
doaj   +2 more sources

Comparison of Vaccine Platforms for Machupo Virus [PDF]

Vaccines
Background/Objectives: Pathogenic mammarenaviruses cause severe hemorrhagic and neurologic disease in humans. Machupo virus (MACV), a New World (NW) mammarenavirus, causes Bolivian hemorrhagic fever in humans, and there are no approved vaccines. Methods:
Rachel Erickson, Hiromi Muramatsu, Sachchidanand Tiwari, Sowmya Sriram, Fernanda Caroline Coirada, Norbert Pardi, Paul Bates   +6 more
doaj   +2 more sources

Special Issue “Arenaviruses 2020”

Viruses, 2021
Rodent-borne arenaviruses have been traditionally predominantly associated with certain muroid species from Mastomys/Praomys genera (African arenaviruses) or with species that belong to murid subfamily Cricetidae (New World arenaviruses) [...]
Igor S. Lukashevich, Juan Carlos de la Torre   +1 more
doaj   +1 more source

Generation of Reporter-Expressing New World Arenaviruses: A Systematic Comparison

Viruses, 2022
Replication-competent reporter-expressing viruses are crucial tools in molecular virology with applications that range from antiviral screening to live-cell imaging of protein spatiotemporal dynamics.
Lucie Fénéant, Anne Leske, Karla Günther, Allison Groseth   +3 more
doaj   +1 more source