Generation of Reporter-Expressing New World Arenaviruses: A Systematic Comparison
Viruses, 2022 Replication-competent reporter-expressing viruses are crucial tools in molecular virology with applications that range from antiviral screening to live-cell imaging of protein spatiotemporal dynamics. However, there is currently little information available regarding viable strategies to develop reporter-expressing arenaviruses.
Lucie Fénéant +3 more
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Widespread recombination, reassortment, and transmission of unbalanced compound viral genotypes in natural arenavirus infections. [PDF]
, 2015 Arenaviruses are one of the largest families of human hemorrhagic fever viruses and are known to infect both mammals and snakes. Arenaviruses package a large (L) and small (S) genome segment in their virions.
Chang, Li-Wen +13 more
core +7 more sources
A new arenavirus in a cluster of fatal transplant-associated diseases [PDF]
, 2008 Three patients who received visceral-organ transplants from a single donor on the same day died of a febrile illness 4 to 6 weeks after transplantation.
Palacios, Gustavo F. +17 more
core +3 more sources
Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses [PDF]
Proceedings of the National Academy of Sciences, 2008 Transferrin receptor 1 (TfR1) is a cellular receptor for the New World hemorrhagic fever arenaviruses Machupo (MACV), Junín (JUNV), and Guanarito (GTOV). Each of these viruses is specifically adapted to a distinct rodent host species, but all cause human disease.
Sheli R, Radoshitzky +11 more
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Different Mechanisms of Cell Entry by Human-Pathogenic Old World and New World Arenaviruses [PDF]
Journal of Virology, 2008 ABSTRACT The Old World arenavirus Lassa virus (LASV) is the causative agent of severe viral hemorrhagic fever (VHF) in humans and is the most prevalent human pathogen among arenaviruses. The present study investigated the largely unknown mechanisms of cell entry of LASV, a process know to be mediated solely by the virus envelope glycoprotein (
Jillian M, Rojek +4 more
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Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses [PDF]
Nature Structural & Molecular Biology, 2010 New World hemorrhagic fever arenaviruses are rodent-borne agents that cause severe human disease. The GP1 subunit of the surface glycoprotein mediates cell attachment through transferrin receptor 1 (TfR1). We report the structure of Machupo virus (MACV) GP1 bound with human TfR1.
Abraham, Jonathan +4 more
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Targeting of arenavirus RNA synthesis by a carboxamide-derivatized aromatic disulfide with virucidal activity. [PDF]
, 2013 Several arenaviruses can cause severe hemorrhagic fever (HF) in humans, representing a public health threat in endemic areas of Africa and South America.
Damonte, Elsa Beatriz +4 more
core +5 more sources
Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses [PDF]
Nature Communications, 2018 AbstractWhile five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the viruses.
Lars E. Clark +12 more
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Differential Disease Susceptibilities in Experimentally Reptarenavirus-Infected Boa Constrictors and Ball Pythons. [PDF]
, 2017 Inclusion body disease (IBD) is an infectious disease originally described in captive snakes. It has traditionally been diagnosed by the presence of large eosinophilic cytoplasmic inclusions and is associated with neurological, gastrointestinal, and ...
Boback, Scott M +9 more
core +1 more source
Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses [PDF]
Nature, 2007 At least five arenaviruses cause viral haemorrhagic fevers in humans. Lassa virus, an Old World arenavirus, uses the cellular receptor alpha-dystroglycan to infect cells. Machupo, Guanarito, Junin and Sabia viruses are New World haemorrhagic fever viruses that do not use alpha-dystroglycan.
Radoshitzky, Sheli R. +11 more
openaire +2 more sources