Results 31 to 40 of about 2,647 (168)

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Sabiá Virus–Like Mammarenavirus in Patient with Fatal Hemorrhagic Fever, Brazil, 2020

Emerging Infectious Diseases, 2020
New World arenaviruses can cause chronic infection in rodents and hemorrhagic fever in humans. We identified a Sabiá virus–like mammarenavirus in a patient with fatal hemorrhagic fever from São Paulo, Brazil.
Fernanda de Mello Malta, Deyvid Amgarten, Ana Catharina de Seixas Santos Nastri, Yeh-Li Ho, Luciana Vilas Boas Casadio, Marcela Basqueira, Gloria Selegatto, Murilo Castro Cervato, Amaro Nunes Duarte-Neto, Hermes Ryoiti Higashino, Felipe Arthur Faustino Medeiros, José Luiz Pinto Lima Gendler, Anna S. Levin, João Renato Rebello Pinho   +13 more
doaj   +1 more source

Differential Immune Responses to New World and Old World Mammalian Arenaviruses [PDF]

International Journal of Molecular Sciences, 2017
Some New World (NW) and Old World (OW) mammalian arenaviruses are emerging, zoonotic viruses that can cause lethal hemorrhagic fever (HF) infections in humans. While these are closely related RNA viruses, the infected hosts appear to mount different types of immune responses against them. Lassa virus (LASV) infection, for example, results in suppressed
openaire   +2 more sources

Single Nucleoprotein Residue Modulates Arenavirus Replication Complex Formation

mBio, 2015
The Arenaviridae are enveloped, negative-sense RNA viruses with several family members that cause hemorrhagic fevers. This work provides immunofluorescence evidence that, unlike those of New World arenaviruses, the replication and transcription complexes
Kristeene A. Knopp, Tuan Ngo, Paul D. Gershon, Michael J. Buchmeier   +3 more
doaj   +1 more source

Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses [PDF]

Journal of Virology, 2019
New World (NW) arenaviruses are a diverse family of emerging zoonotic viruses that merit significant attention as important public health problems. The close genetic relationship of nonpathogenic NW arenaviruses with their highly pathogenic cousins suggests that few mutations may be sufficient to enhance virulence.
Hector Moreno, Rebecca Möller, Chiara Fedeli, Gisa Gerold, Stefan Kunz   +4 more
openaire   +3 more sources

Immunization with GP1 but Not Core-like Particles Displaying Isolated Receptor-Binding Epitopes Elicits Virus-Neutralizing Antibodies against Junín Virus

Vaccines, 2022
New World arenaviruses are rodent-transmitted viruses and include a number of pathogens that are responsible for causing severe human disease. This includes Junín virus (JUNV), which is the causative agent of Argentine hemorrhagic fever.
Gleyder Roman-Sosa, Anne Leske, Xenia Ficht, Tung Huy Dau, Julia Holzerland, Thomas Hoenen, Martin Beer, Robert Kammerer, Reinhold Schirmbeck, Felix A. Rey, Sandra M. Cordo, Allison Groseth   +11 more
doaj   +1 more source

Arenavirus Variations Due to Host-Specific Adaptation

Viruses, 2013
Arenavirus particles are enveloped and contain two single-strand RNA genomic segments with ambisense coding. Genetic plasticity of the arenaviruses comes from transcription errors, segment reassortment, and permissive genomic packaging, and results in ...
Juan C. Zapata, Maria S. Salvato
doaj   +1 more source

Rational design of universal immunotherapy for TfR1-tropic arenaviruses

Nature Communications, 2020
New World arenaviruses utilize the cellular transferrin receptor 1 (TfR1) to enter host cells. Here, the authors develop a TfR1-mimetic immunoadhesin, Arenacept, that targets viral spike complexes and exerts effective pan-reactive neutralization against ...
Hadas Cohen-Dvashi, Ron Amon, Krystle N. Agans, Robert W. Cross, Aliza Borenstein-Katz, Mathieu Mateo, Sylvain Baize, Vered Padler-Karavani, Thomas W. Geisbert, Ron Diskin   +9 more
doaj   +1 more source

Basolateral Entry and Release of New and Old World Arenaviruses from Human Airway Epithelia [PDF]

Journal of Virology, 2008
ABSTRACT Transmission of arenaviruses from rodent hosts to humans is generally thought to occur through inhalation or ingestion of dust or droplets containing viral particles. Here we demonstrate that two identified arenavirus receptors, α-dystroglycan (α-DG) and transferrin receptor 1 (TfR1), are expressed in polarized human airway epithelia.
Douglas E, Dylla, Daniel E, Michele, Kevin P, Campbell, Paul B, McCray   +3 more
openaire   +2 more sources

Novel arenavirus sequences in Hylomyscus sp. and Mus (Nannomys) setulosus from Côte d'Ivoire: implications for evolution of arenaviruses in Africa. [PDF]

PLoS ONE, 2011
This study aimed to identify new arenaviruses and gather insights in the evolution of arenaviruses in Africa. During 2003 through 2005, 1,228 small mammals representing 14 different genera were trapped in 9 villages in south, east, and middle west of ...
David Coulibaly-N'Golo, Bernard Allali, Stéphane K Kouassi, Elisabeth Fichet-Calvet, Beate Becker-Ziaja, Toni Rieger, Stephan Olschläger, Hernri Dosso, Christiane Denys, Jan Ter Meulen, Chantal Akoua-Koffi, Stephan Günther   +11 more
doaj   +1 more source