Results 31 to 40 of about 4,023 (209)

Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. [PDF]

PLoS Pathogens, 2008
A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and ...
Simon Delgado, Bobbie R Erickson, Roberto Agudo, Patrick J Blair, Efrain Vallejo, César G Albariño, Jorge Vargas, James A Comer, Pierre E Rollin, Thomas G Ksiazek, James G Olson, Stuart T Nichol   +11 more
doaj   +1 more source

A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease. [PDF]

, 2016
UNLABELLED: Arenaviruses are emerging viruses including several causative agents of severe hemorrhagic fevers in humans. The advent of next-generation sequencing technology has greatly accelerated the discovery of novel arenavirus species.
Bergeron, E., Burri, D.J., da Palma, J.R., Khatib, A.M., Kunz, S., Oppliger, J., Pasquato, A., Spiropoulou, C.F.   +7 more
core   +1 more source

Differential Immune Responses to New World and Old World Mammalian Arenaviruses [PDF]

International Journal of Molecular Sciences, 2017
Some New World (NW) and Old World (OW) mammalian arenaviruses are emerging, zoonotic viruses that can cause lethal hemorrhagic fever (HF) infections in humans. While these are closely related RNA viruses, the infected hosts appear to mount different types of immune responses against them. Lassa virus (LASV) infection, for example, results in suppressed
openaire   +2 more sources

DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection.

PLoS Pathogens, 2018
Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which countermeasures are urgently needed ...
María Eugenia Loureiro, Andre Luiz Zorzetto-Fernandes, Sheli Radoshitzky, Xiaoli Chi, Simone Dallari, Nuha Marooki, Psylvia Lèger, Sabrina Foscaldi, Vince Harjono, Sonia Sharma, Brian M Zid, Nora López, Nora López, Juan Carlos de la Torre, Sina Bavari, Elina Zúñiga   +15 more
doaj   +1 more source

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Sabiá Virus–Like Mammarenavirus in Patient with Fatal Hemorrhagic Fever, Brazil, 2020

Emerging Infectious Diseases, 2020
New World arenaviruses can cause chronic infection in rodents and hemorrhagic fever in humans. We identified a Sabiá virus–like mammarenavirus in a patient with fatal hemorrhagic fever from São Paulo, Brazil.
Fernanda de Mello Malta, Deyvid Amgarten, Ana Catharina de Seixas Santos Nastri, Yeh-Li Ho, Luciana Vilas Boas Casadio, Marcela Basqueira, Gloria Selegatto, Murilo Castro Cervato, Amaro Nunes Duarte-Neto, Hermes Ryoiti Higashino, Felipe Arthur Faustino Medeiros, José Luiz Pinto Lima Gendler, Anna S. Levin, João Renato Rebello Pinho   +13 more
doaj   +1 more source

Basolateral Entry and Release of New and Old World Arenaviruses from Human Airway Epithelia [PDF]

Journal of Virology, 2008
ABSTRACT Transmission of arenaviruses from rodent hosts to humans is generally thought to occur through inhalation or ingestion of dust or droplets containing viral particles. Here we demonstrate that two identified arenavirus receptors, α-dystroglycan (α-DG) and transferrin receptor 1 (TfR1), are expressed in polarized human airway epithelia.
Douglas E, Dylla, Daniel E, Michele, Kevin P, Campbell, Paul B, McCray   +3 more
openaire   +2 more sources

A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates

Nature Microbiology, 2023
Pathogenic New World arenaviruses (NWAs) cause haemorrhagic fevers and can have high mortality rates, as shown in outbreaks in South America. Neutralizing antibodies (Abs) are critical for protection from NWAs. Having shown that the MOPEVAC vaccine, based on a hyperattenuated arenavirus, induces neutralizing Abs against Lassa fever, we hypothesized ...
Reynard, Stéphanie, Carnec, Xavier, Picard, Caroline, Borges-Cardoso, Virginie, Journeaux, Alexandra, Mateo, Mathieu, Germain, Clara, Hortion, Jimmy, Albrecht, Laure, Perthame, Emeline, Pietrosemoli, Natalia, Vallvé, Audrey, Barron, Stéphane, Duthey, Aurélie, Lacroix, Orianne, Jourjon, Ophélie, Moroso, Marie, Fellmann, Lyne, Moreau, Pierre-Henri, Daniau, Maïlys, Legras-Lachuer, Catherine, Dirheimer, Manon, Carbonnelle, Caroline, Raoul, Hervé, Baize, Sylvain   +24 more
openaire   +3 more sources

Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry of Junín Virus and Other Pathogenic New World Arenaviruses [PDF]

Journal of Virology, 2020
JUNV is one of five known NWAs that cause viral hemorrhagic fever in humans. Countermeasures against JUNV infection are limited to immunization with the Candid#1 vaccine and immune plasma, which are available only in Argentina. The gold standard small animal model for JUNV infection is the guinea pig.
Brady T. Hickerson, Jonna B. Westover, Zhongde Wang, Young-Min Lee, Brian B. Gowen   +4 more
openaire   +4 more sources

Single Nucleoprotein Residue Modulates Arenavirus Replication Complex Formation

mBio, 2015
The Arenaviridae are enveloped, negative-sense RNA viruses with several family members that cause hemorrhagic fevers. This work provides immunofluorescence evidence that, unlike those of New World arenaviruses, the replication and transcription complexes
Kristeene A. Knopp, Tuan Ngo, Paul D. Gershon, Michael J. Buchmeier   +3 more
doaj   +1 more source