Results 21 to 30 of about 2,647 (168)

Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses [PDF]

Nature Structural & Molecular Biology, 2010
New World hemorrhagic fever arenaviruses are rodent-borne agents that cause severe human disease. The GP1 subunit of the surface glycoprotein mediates cell attachment through transferrin receptor 1 (TfR1). We report the structure of Machupo virus (MACV) GP1 bound with human TfR1.
Abraham, Jonathan, Corbett, Kevin D, Farzan, Michael, Choe, Hyeryun, Harrison, Stephen C   +4 more
openaire   +2 more sources

Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry. [PDF]

PLoS ONE, 2011
Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor ...
Sheli R Radoshitzky, Lindsay E Longobardi, Jens H Kuhn, Cary Retterer, Lian Dong, Jeremiah C Clester, Krishna Kota, John Carra, Sina Bavari   +8 more
doaj   +1 more source

Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses [PDF]

Nature, 2007
At least five arenaviruses cause viral haemorrhagic fevers in humans. Lassa virus, an Old World arenavirus, uses the cellular receptor alpha-dystroglycan to infect cells. Machupo, Guanarito, Junin and Sabia viruses are New World haemorrhagic fever viruses that do not use alpha-dystroglycan.
Radoshitzky, Sheli R., Abraham, Jonathan, Spiropoulou, Christina F., Kuhn, Jens H., Nguyen, Dan, Li, Wenhui, Nagel, Jane, Schmidt, Paul J., Nunberg, Jack H., Andrews, Nancy C., Farzan, Michael, Choe, Hyeryun   +11 more
openaire   +2 more sources

MOLECULAR-BIOLOGICAL PECULIARITIES OF ARENAVIRUS REPRODUCTION IN SENSITIVE CELLS

Проблемы особо опасных инфекций, 2017
The Arenaviridae family consists of a large group of single strand ambisense RNA viruses that are separated phylogenetically, serologically and geographically into Old World and New World viruses.
T. E. Sizikova, V. N. Lebedev, V. B. Pantyukhov, A. F. Andrus, S. V. Borisevich   +4 more
doaj   +1 more source

Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.

PLoS Pathogens, 2021
Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World and Old ...
Nicolás Sarute, Han Cheng, Zhonghao Yan, Karen Salas-Briceno, Justin Richner, Lijun Rong, Susan R Ross   +6 more
doaj   +1 more source

Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses [PDF]

Expert Opinion on Drug Discovery, 2012
Seven arenaviruses cause viral hemorrhagic fever in humans: the Old World arenaviruses Lassa and Lujo, and the New World Clade B arenaviruses Machupo (MACV), Junín (JUNV), Guanarito (GTOV), Sabiá (SABV), and Chapare (CHPV). All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates.
Sheli R, Radoshitzky, Jens H, Kuhn, Fabian, de Kok-Mercado, Peter B, Jahrling, Sina, Bavari   +4 more
openaire   +2 more sources

The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers

Проблемы особо опасных инфекций, 2018
Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses.
T. E. Sizikova, V. N. Lebedev, S. I. Syromyatnikova, S. V. Borisevich   +3 more
doaj   +1 more source

The Phylogeny of New World (Tacaribe Complex) Arenaviruses

Virology, 1996
Several New World (Tacaribe complex) arenaviruses (Arenaviridae) are known to cause severe hemorrhagic disease in humans. Phylogenetic reconstruction of the Tacaribe complex arenaviruses previously has been limited by the relative scarcity of sequence data for arenavirus genomes.
BOWEN, MICHAEL D., PETERS, CLARENCE J., NICHOL, STUART T.   +2 more
openaire   +2 more sources

Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. [PDF]

PLoS Pathogens, 2008
A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and ...
Simon Delgado, Bobbie R Erickson, Roberto Agudo, Patrick J Blair, Efrain Vallejo, César G Albariño, Jorge Vargas, James A Comer, Pierre E Rollin, Thomas G Ksiazek, James G Olson, Stuart T Nichol   +11 more
doaj   +1 more source

DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection.

PLoS Pathogens, 2018
Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which countermeasures are urgently needed ...
María Eugenia Loureiro, Andre Luiz Zorzetto-Fernandes, Sheli Radoshitzky, Xiaoli Chi, Simone Dallari, Nuha Marooki, Psylvia Lèger, Sabrina Foscaldi, Vince Harjono, Sonia Sharma, Brian M Zid, Nora López, Nora López, Juan Carlos de la Torre, Sina Bavari, Elina Zúñiga   +15 more
doaj   +1 more source