Results 21 to 30 of about 4,023 (209)

Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. [PDF]

PLoS Pathogens, 2009
Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial ...
Thomas Briese, Janusz T Paweska, Laura K McMullan, Stephen K Hutchison, Craig Street, Gustavo Palacios, Marina L Khristova, Jacqueline Weyer, Robert Swanepoel, Michael Egholm, Stuart T Nichol, W Ian Lipkin   +11 more
doaj   +1 more source

Role of Src family kinases Fyn and Lyn in arenavirus infection. [PDF]

J Virol
Arenaviruses encompass a diverse group of infectious agents, some of which, like Lassa virus (LASV), pose significant threats to global public health due to their acute virulence, while others, such as lymphocytic choriomeningitis virus (LCMV), are less ...
Mao W, Zhou M, Peng C, Wan Y, Li L, Hu J, Liu Y, Peng Y, Shan C, Deng F, Yuan Z, Wang W.   +11 more
europepmc   +2 more sources

Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry. [PDF]

PLoS ONE, 2011
Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor ...
Sheli R Radoshitzky, Lindsay E Longobardi, Jens H Kuhn, Cary Retterer, Lian Dong, Jeremiah C Clester, Krishna Kota, John Carra, Sina Bavari   +8 more
doaj   +1 more source

Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses [PDF]

Expert Opinion on Drug Discovery, 2012
Seven arenaviruses cause viral hemorrhagic fever in humans: the Old World arenaviruses Lassa and Lujo, and the New World Clade B arenaviruses Machupo (MACV), Junín (JUNV), Guanarito (GTOV), Sabiá (SABV), and Chapare (CHPV). All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates.
Sheli R, Radoshitzky, Jens H, Kuhn, Fabian, de Kok-Mercado, Peter B, Jahrling, Sina, Bavari   +4 more
openaire   +2 more sources

MOLECULAR-BIOLOGICAL PECULIARITIES OF ARENAVIRUS REPRODUCTION IN SENSITIVE CELLS

Проблемы особо опасных инфекций, 2017
The Arenaviridae family consists of a large group of single strand ambisense RNA viruses that are separated phylogenetically, serologically and geographically into Old World and New World viruses.
T. E. Sizikova, V. N. Lebedev, V. B. Pantyukhov, A. F. Andrus, S. V. Borisevich   +4 more
doaj   +1 more source

Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.

PLoS Pathogens, 2021
Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World and Old ...
Nicolás Sarute, Han Cheng, Zhonghao Yan, Karen Salas-Briceno, Justin Richner, Lijun Rong, Susan R Ross   +6 more
doaj   +1 more source

The Phylogeny of New World (Tacaribe Complex) Arenaviruses

Virology, 1996
Several New World (Tacaribe complex) arenaviruses (Arenaviridae) are known to cause severe hemorrhagic disease in humans. Phylogenetic reconstruction of the Tacaribe complex arenaviruses previously has been limited by the relative scarcity of sequence data for arenavirus genomes.
BOWEN, MICHAEL D., PETERS, CLARENCE J., NICHOL, STUART T.   +2 more
openaire   +2 more sources

Highly Pathogenic New World and Old World Human Arenaviruses Induce Distinct Interferon Responses in Human Cells [PDF]

Journal of Virology, 2015
ABSTRACT The arenavirus family includes several important pathogens that cause severe and sometimes fatal diseases in humans. The highly pathogenic Old World (OW) arenavirus Lassa fever virus (LASV) is the causative agent of Lassa fever (LF) disease in humans. LASV infections in severe cases are generally immunosuppressive without stimulating
Cheng, Huang, Olga A, Kolokoltsova, Nadezhda E, Yun, Alexey V, Seregin, Shannon, Ronca, Takaaki, Koma, Slobodan, Paessler   +6 more
openaire   +2 more sources

The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers

Проблемы особо опасных инфекций, 2018
Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses.
T. E. Sizikova, V. N. Lebedev, S. I. Syromyatnikova, S. V. Borisevich   +3 more
doaj   +1 more source

Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage [PDF]

, 2010
Background Several arenaviruses cause severe hemorrhagic fever and aseptic meningitis in humans for which no licensed vaccines are available. A major obstacle for vaccine development is pathogen heterogeneity within the Arenaviridae family.
Maya F Kotturi, Jason Botten, Matt Maybeno, John Sidney, Jean Glenn, Huynh-Hoa Bui, Carla Oseroff, Shane Crotty, Bjoern Peters, Howard Grey, Daniel M Altmann, Michael J Buchmeier, Alessandro Sette   +12 more
core   +2 more sources