Results 11 to 20 of about 4,023 (209)

Animal Models of Pathogenic New World Arenaviruses

Microorganisms
Since the emergence of Junín virus in 1953, pathogenic New World arenaviruses have remained a public health concern. These viruses, which also include Machupo virus, Guanarito virus, Sabiá virus, and Chapare virus, cause acute viral hemorrhagic fever and neurological complications, resulting in significant morbidity and mortality.
Alexander V Alvarado, Robert W Cross, Thomas W Geisbert, Courtney Woolsey   +3 more
openaire   +3 more sources

Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses

mSphere, 2018
Several viruses in the Arenaviridae family infect humans and cause severe hemorrhagic fevers which lead to high case fatality rates. Due to their pathogenicity and geographic tropisms, these viruses remain very understudied. As a result, an effective vaccine or therapy is urgently needed.
Fatima Amanat, James Duehr, Lisa Oestereich, Kathryn M. Hastie, Erica Ollmann Saphire, Florian Krammer   +5 more
openaire   +4 more sources

Host-Species Transferrin Receptor 1 Orthologs Are Cellular Receptors for Nonpathogenic New World Clade B Arenaviruses

PLoS Pathogens, 2009
The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever. Amapari (AMAV) and Tacaribe (TCRV), two nonpathogenic NW clade B arenaviruses that do not use human TfR1, are closely related to the NW arenaviruses that cause hemorrhagic fevers ...
Abraham, Jonathan, Kwong, Jo Ann, Albariño, César G., Lu, Jiajie G., Radoshitzky, Sheli R., Salazar-Bravo, Jorge, Farzan, Michael, Spiropoulou, Christina F., Choe, Hyeryun   +8 more
openaire   +5 more sources

Temporal changes in pathology and viral RNA distribution in guinea pigs following separate infection with two New World Arenaviruses

PLOS Neglected Tropical Diseases, 2023
Numerous arenaviruses have been identified throughout the Americas and a subset of these viruses cause viral hemorrhagic fever in humans. This study compared the pathology and viral RNA distribution in Hartley guinea pigs challenged with two human-disease causing New World arenaviruses, Junin virus (JUNV) or Guanarito virus (GTOV).
Curtis Cline, Xiankun Zeng, Todd M. Bell, Carl Shaia, Paul Facemire, Janice Williams, Neil Davis, April Babka, Edwin Picado, Colin Fitzpatrick, Joseph W. Golden   +10 more
openaire   +3 more sources

Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex. [PDF]

mBio
The spillover of New World (NW) arenaviruses from rodent reservoirs into human populations poses a continued risk to human health. NW arenaviruses present a glycoprotein (GP) complex on the envelope surface of the virion, which orchestrates host cell ...
Paesen GC, Ng WM, Kimuda S, Sutton G, Doores KJ, Bowden TA.   +5 more
europepmc   +3 more sources

Special Issue “Arenaviruses 2020”

Viruses, 2021
Rodent-borne arenaviruses have been traditionally predominantly associated with certain muroid species from Mastomys/Praomys genera (African arenaviruses) or with species that belong to murid subfamily Cricetidae (New World arenaviruses) [...]
Igor S. Lukashevich, Juan Carlos de la Torre   +1 more
doaj   +1 more source

Genomic characterization of Sabiá virus in Brazil, 2019-2020: Implications for diagnostics, virus evolution, and receptor binding. [PDF]

PLoS Negl Trop Dis
Between December 2019 and January 2020, two patients suspected of having severe yellow fever were admitted to a tertiary healthcare facility in São Paulo, Brazil, presenting with acute hemorrhagic syndrome and neurological alterations; both cases had ...
Claro IM, Manuli ER, da Silva CAM, Coletti TM, Lemey P, Nastri AC, Casadio LVB, Duarte-Neto AN, Quick J, Romano CM, Whittaker C, Hill SC, Prete CA, Candido DS, Moreira FRR, Ramundo MS, Valença IN, de Jesus JG, Sales FCS, Cunha MS, Guerra JM, Mendes-Correa MC, Tozetto-Mendoza TR, Fumagalli MJ, Ho YL, Simmonds P, Ng WM, Bowden TA, de Souza WM, Pybus OG, Levin AS, Loman N, Sabino EC, Faria NR.   +33 more
europepmc   +2 more sources

A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses. [PDF]

Viruses
The Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells.
Kang Q, Li G, Wu Y, Wang S, Chen Z, Zai X, Pan X, Wang R, Lu J, Du P, Yang Z, Chi X, Xiao G, Xu J.   +13 more
europepmc   +2 more sources

Climate-driven changes in zoonotic risk of arenaviral hemorrhagic fevers in South America. [PDF]

Npj Viruses
Climate change is expected to significantly alter the ecological dynamics of zoonotic diseases, yet its long-term impact on rodent-borne hemorrhagic fevers in South America remains poorly understood.
Kulkarni PS, Flores-Pérez NY, Jian AH, Bird BH, Johnson CK, Uhart M, Pandit PS.   +6 more
europepmc   +2 more sources

Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

mBio, 2022
Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1).
Weng M. Ng, Mehmet Sahin, Stefanie A. Krumm, Jeffrey Seow, Antra Zeltina, Karl Harlos, Guido C. Paesen, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden   +9 more
doaj   +1 more source