Results 11 to 20 of about 2,648 (168)

Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.

PLoS Pathogens, 2009
The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever.
Jonathan Abraham, Jo Ann Kwong, César G Albariño, Jiajie G Lu, Sheli R Radoshitzky, Jorge Salazar-Bravo, Michael Farzan, Christina F Spiropoulou, Hyeryun Choe   +8 more
doaj   +6 more sources

Role of Src family kinases Fyn and Lyn in arenavirus infection [PDF]

Journal of Virology
Arenaviruses encompass a diverse group of infectious agents, some of which, like Lassa virus (LASV), pose significant threats to global public health due to their acute virulence, while others, such as lymphocytic choriomeningitis virus (LCMV), are less ...
Wenting Mao, Minmin Zhou, Cheng Peng, Yi Wan, Li Li, Jialing Hu, Yang Liu, Yuan Peng, Chao Shan, Fei Deng, Zhiming Yuan, Wei Wang   +11 more
doaj   +2 more sources

Comparison of Vaccine Platforms for Machupo Virus [PDF]

Vaccines
Background/Objectives: Pathogenic mammarenaviruses cause severe hemorrhagic and neurologic disease in humans. Machupo virus (MACV), a New World (NW) mammarenavirus, causes Bolivian hemorrhagic fever in humans, and there are no approved vaccines. Methods:
Rachel Erickson, Hiromi Muramatsu, Sachchidanand Tiwari, Sowmya Sriram, Fernanda Caroline Coirada, Norbert Pardi, Paul Bates   +6 more
doaj   +2 more sources

Glycoprotein-Specific Polyclonal Antibodies Targeting Machupo Virus Protect Guinea Pigs against Lethal Infection [PDF]

Vaccines
Convalescent plasma has been shown to be effective at protecting humans against severe diseases caused by New World (NW) arenaviruses, including Junin virus (JUNV) and Machupo virus (MACV).
Joseph W. Golden, Steven A. Kwilas, Jay W. Hooper   +2 more
doaj   +2 more sources

Discovery and biological confirmation of a highly divergent Tacaribe virus in metatranscriptomic data from neotropical bats [PDF]

mSphere
First isolated from neotropical fruit bats in Trinidad in 1956, Tacaribe virus (TCRV) has rarely been detected since. We searched for New World arenavirus reads in roughly 5.7 million sequencing runs available on public databases using Serratus.
Carlo Fischer, Murilo Henrique Anzolini Cassiano, William R. Thomas, Liliana M. Dávalos, Yolanda Leon, Jackeline Salazar, Stephen J. Rossiter, Andres Moreira-Soto, Jan Felix Drexler   +8 more
doaj   +2 more sources

Special Issue “Arenaviruses 2020”

Viruses, 2021
Rodent-borne arenaviruses have been traditionally predominantly associated with certain muroid species from Mastomys/Praomys genera (African arenaviruses) or with species that belong to murid subfamily Cricetidae (New World arenaviruses) [...]
Igor S. Lukashevich, Juan Carlos de la Torre   +1 more
doaj   +1 more source

Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

mBio, 2022
Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1).
Weng M. Ng, Mehmet Sahin, Stefanie A. Krumm, Jeffrey Seow, Antra Zeltina, Karl Harlos, Guido C. Paesen, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden   +9 more
doaj   +1 more source

Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. [PDF]

PLoS Pathogens, 2009
Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial ...
Thomas Briese, Janusz T Paweska, Laura K McMullan, Stephen K Hutchison, Craig Street, Gustavo Palacios, Marina L Khristova, Jacqueline Weyer, Robert Swanepoel, Michael Egholm, Stuart T Nichol, W Ian Lipkin   +11 more
doaj   +1 more source

Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses [PDF]

Proceedings of the National Academy of Sciences, 2008
Transferrin receptor 1 (TfR1) is a cellular receptor for the New World hemorrhagic fever arenaviruses Machupo (MACV), Junín (JUNV), and Guanarito (GTOV). Each of these viruses is specifically adapted to a distinct rodent host species, but all cause human disease. Here we compare the ability of these viruses to use various mammalian
Sheli R, Radoshitzky, Jens H, Kuhn, Christina F, Spiropoulou, César G, Albariño, Dan P, Nguyen, Jorge, Salazar-Bravo, Tatyana, Dorfman, Amy S, Lee, Enxiu, Wang, Susan R, Ross, Hyeryun, Choe, Michael, Farzan   +11 more
openaire   +2 more sources

Different Mechanisms of Cell Entry by Human-Pathogenic Old World and New World Arenaviruses [PDF]

Journal of Virology, 2008
ABSTRACT The Old World arenavirus Lassa virus (LASV) is the causative agent of severe viral hemorrhagic fever (VHF) in humans and is the most prevalent human pathogen among arenaviruses. The present study investigated the largely unknown mechanisms of cell entry of LASV, a process know to be mediated solely by the virus envelope glycoprotein (
Rojek, Jillian M., Sanchez, Ana B., Nguyen, Ngoc Thao, de la Torre, Juan-Carlos, Kunz, Stefan   +4 more
openaire   +3 more sources