Results 41 to 50 of about 2,647 (168)

Highly Pathogenic New World and Old World Human Arenaviruses Induce Distinct Interferon Responses in Human Cells [PDF]

Journal of Virology, 2015
ABSTRACT The arenavirus family includes several important pathogens that cause severe and sometimes fatal diseases in humans. The highly pathogenic Old World (OW) arenavirus Lassa fever virus (LASV) is the causative agent of Lassa fever (LF) disease in humans. LASV infections in severe cases are generally immunosuppressive without stimulating
Cheng, Huang, Olga A, Kolokoltsova, Nadezhda E, Yun, Alexey V, Seregin, Shannon, Ronca, Takaaki, Koma, Slobodan, Paessler   +6 more
openaire   +2 more sources

A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates

Nature Microbiology, 2023
Pathogenic New World arenaviruses (NWAs) cause haemorrhagic fevers and can have high mortality rates, as shown in outbreaks in South America. Neutralizing antibodies (Abs) are critical for protection from NWAs. Having shown that the MOPEVAC vaccine, based on a hyperattenuated arenavirus, induces neutralizing Abs against Lassa fever, we hypothesized ...
Reynard, Stéphanie, Carnec, Xavier, Picard, Caroline, Borges-Cardoso, Virginie, Journeaux, Alexandra, Mateo, Mathieu, Germain, Clara, Hortion, Jimmy, Albrecht, Laure, Perthame, Emeline, Pietrosemoli, Natalia, Vallvé, Audrey, Barron, Stéphane, Duthey, Aurélie, Lacroix, Orianne, Jourjon, Ophélie, Moroso, Marie, Fellmann, Lyne, Moreau, Pierre-Henri, Daniau, Maïlys, Legras-Lachuer, Catherine, Dirheimer, Manon, Carbonnelle, Caroline, Raoul, Hervé, Baize, Sylvain   +24 more
openaire   +3 more sources

Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020

Emerging Infectious Diseases, 2020
We report a case of Argentine hemorrhagic fever diagnosed in a woman in Belgium who traveled from a disease-endemic area. Patient management included supportive care and combination therapy with ribavirin and favipiravir.
Ioannis Veliziotis, Alain Roman, Delphine Martiny, Gerlind Schuldt, Marc Claus, Nicolas Dauby, Sigi Van den Wijngaert, Charlotte Martin, Rakan Nasreddine, Claudia Perandones, Romain Mahieu, Corien Swaan, Serge Van Praet, Deborah Konopnicki, Maria A. Morales, Denis Malvy, Etienne Stevens, Philippe Dechamps, Erika Vlieghe, Olivier Vandenberg, Stephan Günther, Michèle Gérard   +21 more
doaj   +1 more source

Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry of Junín Virus and Other Pathogenic New World Arenaviruses [PDF]

Journal of Virology, 2020
JUNV is one of five known NWAs that cause viral hemorrhagic fever in humans. Countermeasures against JUNV infection are limited to immunization with the Candid#1 vaccine and immune plasma, which are available only in Argentina. The gold standard small animal model for JUNV infection is the guinea pig.
Brady T. Hickerson, Jonna B. Westover, Zhongde Wang, Young-Min Lee, Brian B. Gowen   +4 more
openaire   +3 more sources

Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses

Current Opinion in Microbiology, 2011
At least five New World arenaviruses cause severe human hemorrhagic fevers. These viruses are transmitted to humans through contact with their respective South American rodent hosts. Each uses human transferrin receptor 1 (TfR1) as its obligate receptor.
Choe, Hyeryun, Jemielity, Stephanie, Abraham, Jonathan, Radoshitzky, Sheli R, Farzan, Michael   +4 more
openaire   +2 more sources

Co-circulation of Clade C New World Arenaviruses: New geographic distribution and host species

Infection, Genetics and Evolution, 2015
Clade C, of the New World Arenaviruses, is composed of only the Latino and Oliveros viruses and, besides the geographic range of their rodent reservoirs, the distribution of these viruses has been restricted to Bolivia and Argentina. In this study, the genetic detection and phylogenetic analysis of the complete S segment sequences of sympatric ...
Fernandes, Jorlan, de Oliveira, Renata Carvalho, Guterres, Alexandro, de Carvalho Serra, Fabiana, Bonvicino, Cibele Rodrigues, D’Andrea, Paulo Sergio, Cunha, Rivaldo Venâncio, Levis, Silvana, de Lemos, Elba Regina Sampaio   +8 more
openaire   +2 more sources

Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction [PDF]

Journal of Virology, 2010
ABSTRACT The retinoic acid-inducible gene I product (RIG-I) is a cellular sensor of RNA virus infection that regulates the cellular beta interferon (IFN-β) response. The nucleoproteins (NP) of arenaviruses are reported to antagonize the IFN response by inhibiting interferon regulatory factor 3 (IRF-3). Here, we demonstrate that the Z proteins
Lina, Fan, Thomas, Briese, W Ian, Lipkin
openaire   +2 more sources

Putting Rodents at the Center of One Health Programs: A Narrative Synthesis

Integrative Zoology, EarlyView.
Rodents link human, animal, and environmental health across diverse ecosystems. Rodent diversity underpins both zoonotic disease risk and ecosystem function. Environmental change reshapes rodent communities and spillover dynamics. Rodents act as reservoirs, amplifiers, and sentinels of emerging pathogens.
Steven R. Belmain
wiley   +1 more source

Research Direction and Science Evaluation: The Role of Coherence and Alignment

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT The decisions of funding agencies greatly influence the direction of scientific research; however, our understanding of how applicants' research directions affect the selection process remains limited. In this study, we investigate how a project's coherence with a scientist's previous work and its alignment with current scientific trends ...
Charles Ayoubi, Sandra Barbosu, Michele Pezzoni, Fabiana Visentin   +3 more
wiley   +1 more source

Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses [PDF]

Journal of Virology, 2015
ABSTRACT Animal viruses frequently cause zoonotic disease in humans. As these viruses are highly diverse, evaluating the threat that they pose remains a major challenge, and efficient approaches are needed to rapidly predict virus-host compatibility.
Scott A, Kerr, Eleisha L, Jackson, Oana I, Lungu, Austin G, Meyer, Ann, Demogines, Andrew D, Ellington, George, Georgiou, Claus O, Wilke, Sara L, Sawyer   +8 more
openaire   +2 more sources