Results 41 to 50 of about 23,401,483 (196)

Basolateral Entry and Release of New and Old World Arenaviruses from Human Airway Epithelia [PDF]

Journal of Virology, 2008
ABSTRACT Transmission of arenaviruses from rodent hosts to humans is generally thought to occur through inhalation or ingestion of dust or droplets containing viral particles. Here we demonstrate that two identified arenavirus receptors, α-dystroglycan (α-DG) and transferrin receptor 1 (TfR1), are expressed in polarized human airway epithelia.
Douglas E, Dylla, Daniel E, Michele, Kevin P, Campbell, Paul B, McCray   +3 more
openaire   +2 more sources

Immunization with GP1 but Not Core-like Particles Displaying Isolated Receptor-Binding Epitopes Elicits Virus-Neutralizing Antibodies against Junín Virus

Vaccines, 2022
New World arenaviruses are rodent-transmitted viruses and include a number of pathogens that are responsible for causing severe human disease. This includes Junín virus (JUNV), which is the causative agent of Argentine hemorrhagic fever.
Gleyder Roman-Sosa, Anne Leske, Xenia Ficht, Tung Huy Dau, Julia Holzerland, Thomas Hoenen, Martin Beer, Robert Kammerer, Reinhold Schirmbeck, Felix A. Rey, Sandra M. Cordo, Allison Groseth   +11 more
doaj   +1 more source

Highly Pathogenic New World and Old World Human Arenaviruses Induce Distinct Interferon Responses in Human Cells [PDF]

Journal of Virology, 2015
ABSTRACT The arenavirus family includes several important pathogens that cause severe and sometimes fatal diseases in humans. The highly pathogenic Old World (OW) arenavirus Lassa fever virus (LASV) is the causative agent of Lassa fever (LF) disease in humans. LASV infections in severe cases are generally immunosuppressive without stimulating
Cheng, Huang, Olga A, Kolokoltsova, Nadezhda E, Yun, Alexey V, Seregin, Shannon, Ronca, Takaaki, Koma, Slobodan, Paessler   +6 more
openaire   +2 more sources

Novel arenavirus sequences in Hylomyscus sp. and Mus (Nannomys) setulosus from Côte d'Ivoire: implications for evolution of arenaviruses in Africa. [PDF]

PLoS ONE, 2011
This study aimed to identify new arenaviruses and gather insights in the evolution of arenaviruses in Africa. During 2003 through 2005, 1,228 small mammals representing 14 different genera were trapped in 9 villages in south, east, and middle west of ...
David Coulibaly-N'Golo, Bernard Allali, Stéphane K Kouassi, Elisabeth Fichet-Calvet, Beate Becker-Ziaja, Toni Rieger, Stephan Olschläger, Hernri Dosso, Christiane Denys, Jan Ter Meulen, Chantal Akoua-Koffi, Stephan Günther   +11 more
doaj   +1 more source

World Development Indicators 2011 [PDF]

, 2011
World development indicators 2011, the 15th edition in its current format, aims to provide relevant, high-quality, internationally comparable statistics about development and the quality of people's ...
World Bank
core   +1 more source

A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates

Nature Microbiology, 2023
Pathogenic New World arenaviruses (NWAs) cause haemorrhagic fevers and can have high mortality rates, as shown in outbreaks in South America. Neutralizing antibodies (Abs) are critical for protection from NWAs. Having shown that the MOPEVAC vaccine, based on a hyperattenuated arenavirus, induces neutralizing Abs against Lassa fever, we hypothesized ...
Reynard, Stéphanie, Carnec, Xavier, Picard, Caroline, Borges-Cardoso, Virginie, Journeaux, Alexandra, Mateo, Mathieu, Germain, Clara, Hortion, Jimmy, Albrecht, Laure, Perthame, Emeline, Pietrosemoli, Natalia, Vallvé, Audrey, Barron, Stéphane, Duthey, Aurélie, Lacroix, Orianne, Jourjon, Ophélie, Moroso, Marie, Fellmann, Lyne, Moreau, Pierre-Henri, Daniau, Maïlys, Legras-Lachuer, Catherine, Dirheimer, Manon, Carbonnelle, Caroline, Raoul, Hervé, Baize, Sylvain   +24 more
openaire   +3 more sources

Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020

Emerging Infectious Diseases, 2020
We report a case of Argentine hemorrhagic fever diagnosed in a woman in Belgium who traveled from a disease-endemic area. Patient management included supportive care and combination therapy with ribavirin and favipiravir.
Ioannis Veliziotis, Alain Roman, Delphine Martiny, Gerlind Schuldt, Marc Claus, Nicolas Dauby, Sigi Van den Wijngaert, Charlotte Martin, Rakan Nasreddine, Claudia Perandones, Romain Mahieu, Corien Swaan, Serge Van Praet, Deborah Konopnicki, Maria A. Morales, Denis Malvy, Etienne Stevens, Philippe Dechamps, Erika Vlieghe, Olivier Vandenberg, Stephan Günther, Michèle Gérard   +21 more
doaj   +1 more source

Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry of Junín Virus and Other Pathogenic New World Arenaviruses [PDF]

Journal of Virology, 2020
JUNV is one of five known NWAs that cause viral hemorrhagic fever in humans. Countermeasures against JUNV infection are limited to immunization with the Candid#1 vaccine and immune plasma, which are available only in Argentina. The gold standard small animal model for JUNV infection is the guinea pig.
Brady T. Hickerson, Jonna B. Westover, Zhongde Wang, Young-Min Lee, Brian B. Gowen   +4 more
openaire   +3 more sources

Phylogeny and evolution of old world arenaviruses [PDF]

, 2006
The intention of this study was to investigate the genomics, phylogeny and evolution of the Old World arenaviruses based on sequence data representing the four viral genes. To achieve this aim, we sequenced the complete S and L RNA segments of Ippy virus
Charrel, Rémi N., Emonet, Sébastien, Lamballerie, Xavier de, Lemasson, Jean-Jacques, Gonzalez, Jean-Paul, de Lamballerie, Xavier, Charrel, Rémi   +6 more
core   +1 more source

Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses

Current Opinion in Microbiology, 2011
At least five New World arenaviruses cause severe human hemorrhagic fevers. These viruses are transmitted to humans through contact with their respective South American rodent hosts. Each uses human transferrin receptor 1 (TfR1) as its obligate receptor.
Choe, Hyeryun, Jemielity, Stephanie, Abraham, Jonathan, Radoshitzky, Sheli R, Farzan, Michael   +4 more
openaire   +2 more sources