Results 41 to 50 of about 4,023 (209)

Co-infecting Reptarenaviruses Can Be Vertically Transmitted in Boa Constrictor [PDF]

, 2017
Boid inclusion body disease (BIBD) is an often fatal disease affecting mainly constrictor snakes. BIBD has been associated with infection, and more recently with coinfection, by various reptarenavirus species (family Arenaviridae). Thus far BIBD has only
Hepojoki, Jussi, Hetzel, Udo, Keller, Saskia, Kipar, Anja, Korzyukov, Yegor, Sironen, Tarja, Vapalahti, Olli   +6 more
core   +2 more sources

Immunization with GP1 but Not Core-like Particles Displaying Isolated Receptor-Binding Epitopes Elicits Virus-Neutralizing Antibodies against Junín Virus

Vaccines, 2022
New World arenaviruses are rodent-transmitted viruses and include a number of pathogens that are responsible for causing severe human disease. This includes Junín virus (JUNV), which is the causative agent of Argentine hemorrhagic fever.
Gleyder Roman-Sosa, Anne Leske, Xenia Ficht, Tung Huy Dau, Julia Holzerland, Thomas Hoenen, Martin Beer, Robert Kammerer, Reinhold Schirmbeck, Felix A. Rey, Sandra M. Cordo, Allison Groseth   +11 more
doaj   +1 more source

Arenavirus Variations Due to Host-Specific Adaptation

Viruses, 2013
Arenavirus particles are enveloped and contain two single-strand RNA genomic segments with ambisense coding. Genetic plasticity of the arenaviruses comes from transcription errors, segment reassortment, and permissive genomic packaging, and results in ...
Juan C. Zapata, Maria S. Salvato
doaj   +1 more source

Rational design of universal immunotherapy for TfR1-tropic arenaviruses

Nature Communications, 2020
New World arenaviruses utilize the cellular transferrin receptor 1 (TfR1) to enter host cells. Here, the authors develop a TfR1-mimetic immunoadhesin, Arenacept, that targets viral spike complexes and exerts effective pan-reactive neutralization against ...
Hadas Cohen-Dvashi, Ron Amon, Krystle N. Agans, Robert W. Cross, Aliza Borenstein-Katz, Mathieu Mateo, Sylvain Baize, Vered Padler-Karavani, Thomas W. Geisbert, Ron Diskin   +9 more
doaj   +1 more source

Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses [PDF]

Journal of Virology, 2019
New World (NW) arenaviruses are a diverse family of emerging zoonotic viruses that merit significant attention as important public health problems. The close genetic relationship of nonpathogenic NW arenaviruses with their highly pathogenic cousins suggests that few mutations may be sufficient to enhance virulence.
Hector Moreno, Rebecca Möller, Chiara Fedeli, Gisa Gerold, Stefan Kunz   +4 more
openaire   +2 more sources

Analyzing Machupo virus-receptor binding by molecular dynamics simulations [PDF]

, 2014
In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein-protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases.
Ellington, Andrew D., Meyer, Austin G., Sawyer, Sara L., Wilke, Claus O.   +3 more
core   +2 more sources

Co-circulation of Clade C New World Arenaviruses: New geographic distribution and host species

Infection, Genetics and Evolution, 2015
Clade C, of the New World Arenaviruses, is composed of only the Latino and Oliveros viruses and, besides the geographic range of their rodent reservoirs, the distribution of these viruses has been restricted to Bolivia and Argentina. In this study, the genetic detection and phylogenetic analysis of the complete S segment sequences of sympatric ...
Fernandes, Jorlan, de Oliveira, Renata Carvalho, Guterres, Alexandro, de Carvalho Serra, Fabiana, Bonvicino, Cibele Rodrigues, D’Andrea, Paulo Sergio, Cunha, Rivaldo Venâncio, Levis, Silvana, de Lemos, Elba Regina Sampaio   +8 more
openaire   +2 more sources

Novel arenavirus sequences in Hylomyscus sp. and Mus (Nannomys) setulosus from Côte d'Ivoire: implications for evolution of arenaviruses in Africa. [PDF]

PLoS ONE, 2011
This study aimed to identify new arenaviruses and gather insights in the evolution of arenaviruses in Africa. During 2003 through 2005, 1,228 small mammals representing 14 different genera were trapped in 9 villages in south, east, and middle west of ...
David Coulibaly-N'Golo, Bernard Allali, Stéphane K Kouassi, Elisabeth Fichet-Calvet, Beate Becker-Ziaja, Toni Rieger, Stephan Olschläger, Hernri Dosso, Christiane Denys, Jan Ter Meulen, Chantal Akoua-Koffi, Stephan Günther   +11 more
doaj   +1 more source

Arenavirus budding resulting from viral-protein-associated cell membrane curvature [PDF]

, 2013
Viral replication occurs within cells, with release (and onward infection) primarily achieved through two alternative mechanisms: lysis, in which virions emerge as the infected cell dies and bursts open; or budding, in which virions emerge gradually from
Abelson HT, Benjamin W. Neuman, Cheng RH, Coronel EC, Dalton A, David Schley, Dawkins R, Ghosal S, Harty RN, Justice PA, Lehmann-Grube F, Li Y, Murphy FA, Press WH, Puffer BA, Robert J. Whittaker, Schalich J, Suomalainen M, Weldon R   +18 more
core   +1 more source

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression [PDF]

, 2017
Immune-mediated effector molecules can limit cancer growth, but lack of sustained immune activation in the tumour microenvironment restricts antitumour immunity.
Gassa, Asmae, Helfrich, Iris, Kalkavan, Halime, Kasper, Stefan, Lohning, Max, Pandyra, Aleksandra A., Sharma, Piyush, Virchow, Isabel, Willimsky, Gerald   +8 more
core   +1 more source