Results 51 to 60 of about 4,023 (209)

Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020

Emerging Infectious Diseases, 2020
We report a case of Argentine hemorrhagic fever diagnosed in a woman in Belgium who traveled from a disease-endemic area. Patient management included supportive care and combination therapy with ribavirin and favipiravir.
Ioannis Veliziotis, Alain Roman, Delphine Martiny, Gerlind Schuldt, Marc Claus, Nicolas Dauby, Sigi Van den Wijngaert, Charlotte Martin, Rakan Nasreddine, Claudia Perandones, Romain Mahieu, Corien Swaan, Serge Van Praet, Deborah Konopnicki, Maria A. Morales, Denis Malvy, Etienne Stevens, Philippe Dechamps, Erika Vlieghe, Olivier Vandenberg, Stephan Günther, Michèle Gérard   +21 more
doaj   +1 more source

Family-specific degenerate primer design: a tool to design consensus degenerated oligonucleotides [PDF]

, 2013
Designing degenerate PCR primers for templates of unknown nucleotide sequence may be a very difficult task. In this paper, we present a new method to design degenerate primers, implemented in family-specific degenerate primer design (FAS-DPD) computer ...
Borio, Cristina Silvia, Ghiringhelli, Pablo Daniel, Goñi, Sandra Elizabeth, Iserte, Javier Alonso, Lozano, Mario Enrique, Stephan, Betina Inés   +5 more
core   +3 more sources

Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction [PDF]

Journal of Virology, 2010
ABSTRACT The retinoic acid-inducible gene I product (RIG-I) is a cellular sensor of RNA virus infection that regulates the cellular beta interferon (IFN-β) response. The nucleoproteins (NP) of arenaviruses are reported to antagonize the IFN response by inhibiting interferon regulatory factor 3 (IRF-3). Here, we demonstrate that the Z proteins
Lina, Fan, Thomas, Briese, W Ian, Lipkin
openaire   +2 more sources

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses. [PDF]

, 2014
Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses.
Davis, Benjamin, Freedman, Bruce D, Han, Ziying, Harty, Ronald N, Lee, Michael S, Liu, Yuliang, Lu, Jianhong, Olson, Mark A, Reitz, Allen B, Ruthel, Gordon, Schnell, Matthias J, Wrobel, Jay E   +11 more
core   +2 more sources

Interaction of silver nanoparticles with Tacaribe virus [PDF]

, 2010
Background Silver nanoparticles possess many unique properties that make them attractive for use in biological applications. Recently they received attention when it was shown that 10 nm silver nanoparticles were bactericidal, which is ...
Janice L Speshock, Richard C Murdock, Laura K Braydich-Stolle, Amanda M Schrand, Saber M Hussain   +4 more
core   +2 more sources

Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses

Antiviral Research, 2006
Category A arenaviruses as defined by the National Institute of Allergy and Infectious Diseases (NIAID) are human pathogens that could be weaponized by bioterrorists. Many of these deadly viruses require biosafety level-4 (BSL-4) containment for all laboratory work, which limits traditional laboratory high-throughput screening (HTS) for identification ...
Bolken, Tove′ C., Laquerre, Sylvie, Zhang, Yuanming, Bailey, Thomas R., Pevear, Daniel C., Kickner, Shirley S., Sperzel, Lindsey E., Jones, Kevin F., Warren, Travis K., Amanda Lund, S., Kirkwood-Watts, Dana L., King, David S., Shurtleff, Amy C., Guttieri, Mary C., Deng, Yijun, Bleam, Maureen, Hruby, Dennis E.   +16 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses

Current Opinion in Microbiology, 2011
At least five New World arenaviruses cause severe human hemorrhagic fevers. These viruses are transmitted to humans through contact with their respective South American rodent hosts. Each uses human transferrin receptor 1 (TfR1) as its obligate receptor.
Choe, Hyeryun, Jemielity, Stephanie, Abraham, Jonathan, Radoshitzky, Sheli R, Farzan, Michael   +4 more
openaire   +2 more sources

Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses [PDF]

Journal of Virology, 2015
ABSTRACT Animal viruses frequently cause zoonotic disease in humans. As these viruses are highly diverse, evaluating the threat that they pose remains a major challenge, and efficient approaches are needed to rapidly predict virus-host compatibility.
Scott A, Kerr, Eleisha L, Jackson, Oana I, Lungu, Austin G, Meyer, Ann, Demogines, Andrew D, Ellington, George, Georgiou, Claus O, Wilke, Sara L, Sawyer   +8 more
openaire   +2 more sources

Research Direction and Science Evaluation: The Role of Coherence and Alignment

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT The decisions of funding agencies greatly influence the direction of scientific research; however, our understanding of how applicants' research directions affect the selection process remains limited. In this study, we investigate how a project's coherence with a scientist's previous work and its alignment with current scientific trends ...
Charles Ayoubi, Sandra Barbosu, Michele Pezzoni, Fabiana Visentin   +3 more
wiley   +1 more source