Development of Reverse Genetics for the Prototype New World Mammarenavirus Tacaribe Virus. [PDF]
J Virol, 2020 To date, no Food and Drug Administration (FDA)-approved vaccines are available to combat hemorrhagic fever caused by mammarenavirus infections in humans. Treatment of mammarenavirus infections is limited to the off-label use of ribavirin, which is partially effective and associated with significant side effects.
Ye C +2 more
europepmc +6 more sources
Genetic Evidence for a Tacaribe Serocomplex Virus, Mexico
Emerging Infectious Diseases, 2010 We isolated arenavirus RNA from white-toothed woodrats (Neotoma leucodon) captured in a region of Mexico in which woodrats are food for humans. Analyses of nucleotide and amino acid sequence data indicated that the woodrats were infected with a novel ...
Catherine C. Inizan +5 more
doaj +4 more sources
Integrated molecular and metatranscriptomic evidence of Tacaribe virus and the brain virome profile of Molossus molossus bat sampled in Brazil [PDF]
Microbiology SpectrumTacaribe virus (TCRV), a New World arenavirus, is associated with neotropical frugivorous bats, particularly Artibeus spp., and is considered to have zoonotic potential.
Larissa Leão F. de Sousa +11 more
doaj +2 more sources
BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis. [PDF]
PLoS Pathogens, 2020 Pathogenicity often differs dramatically among even closely related arenavirus species. For instance, Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is closely related to Tacaribe virus (TCRV), which is normally avirulent ...
Julia Holzerland +5 more
doaj +2 more sources
TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. [PDF]
PLoS Pathogens, 2013 Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4) specifically bind phosphatidylserine (PS). TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and as an entry factor for dengue ...
Stephanie Jemielity +11 more
doaj +5 more sources
Discovery and biological confirmation of a highly divergent Tacaribe virus in metatranscriptomic data from neotropical bats [PDF]
mSphereFirst isolated from neotropical fruit bats in Trinidad in 1956, Tacaribe virus (TCRV) has rarely been detected since. We searched for New World arenavirus reads in roughly 5.7 million sequencing runs available on public databases using Serratus.
Carlo Fischer +8 more
doaj +2 more sources
Family-specific degenerate primer design: a tool to design consensus degenerated oligonucleotides [PDF]
Biotechnology Research International, Volume 2013, Issue 1, 2013., 2013 Designing degenerate PCR primers for templates of unknown nucleotide sequence may be a very difficult task. In this paper, we present a new method to design degenerate primers, implemented in family-specific degenerate primer design (FAS-DPD) computer ...
Borio, Cristina Silvia +5 more
core +4 more sources
A dsRNA-binding mutant reveals only a minor role of exonuclease activity in interferon antagonism by the arenavirus nucleoprotein. [PDF]
PLoS Pathogens, 2023 The arenavirus nucleoprotein (NP) plays an important role in the virus' ability to block interferon (IFN) production, and its exonuclease function appears to contribute to this activity.
Patrick Bohn +6 more
doaj +4 more sources
Efficient budding of the tacaribe virus matrix protein z requires the nucleoprotein. [PDF]
J Virol, 2010 ABSTRACT The Z protein has been shown for several arenaviruses to serve as the viral matrix protein. As such, Z provides the principal force for the budding of virus particles and is capable of forming virus-like particles (VLPs) when expressed alone.
Groseth A +4 more
europepmc +4 more sources
Molecular characterization of arenavirus defective viral genomes reveals sequence features associated with their formation [PDF]
Journal of VirologyDefective viral genomes (DVGs) are byproducts of replication that arise during infection with diverse RNA viruses and can impact virus infection and disease outcome.
Thomas Hoenen +5 more
doaj +2 more sources