Results 11 to 20 of about 4,888 (173)
Virology, 2011 Several arenaviruses, chiefly Lassa virus, cause hemorrhagic fever disease in humans and pose a significant public health problem in their endemic regions. On the other hand the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus-host interactions and associated disease.
Juan De La Torre, Shuzo Urata
exaly +3 more sources
Entry inhibitors as arenavirus antivirals
Frontiers in MicrobiologyArenaviruses belonging to the Arenaviridae family, genus mammarenavirus, are enveloped, single-stranded RNA viruses primarily found in rodent species, that cause severe hemorrhagic fever in humans. With high mortality rates and limited treatment options, the search for effective antivirals is imperative.
Susan R Ross
exaly +4 more sources
Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates [PDF]
VaccinesArenavirus-based vectors are being investigated as therapeutic vaccine candidates with the potential to elicit robust CD8 T-cell responses. We compared the immunogenicity of replicating (artPICV and artLCMV) and non-replicating (rPICV and rLCMV ...
Bhawna Sharma +19 more
doaj +2 more sources
Generation of Reporter-Expressing New World Arenaviruses: A Systematic Comparison
Viruses, 2022 Replication-competent reporter-expressing viruses are crucial tools in molecular virology with applications that range from antiviral screening to live-cell imaging of protein spatiotemporal dynamics.
Lucie Fénéant +3 more
doaj +1 more source
Viruses, 2022 Arenaviruses include important zoonotic pathogens that cause hemorrhagic fever (e.g., Junín virus; JUNV) as well as other viruses that are closely related but apathogenic (e.g., Tacaribe virus; TCRV).
Julia Holzerland +2 more
doaj +1 more source
Highly Diverse Arenaviruses in Neotropical Bats, Brazil
Emerging Infectious Diseases, 2022 We detected arenavirus RNA in 1.6% of 1,047 bats in Brazil that were sampled during 2007–2011. We identified Tacaribe virus in 2 Artibeus sp. bats and a new arenavirus species in Carollia perspicillata bats that we named Tietê mammarenavirus.
Luiz Gustavo Bentim Góes +14 more
doaj +1 more source
Visualizing lymphocytic choriomeningitis virus infection in cells and living mice
iScience, 2022 Summary: Mammarenavirus are a large family of enveloped negative-strand RNA viruses that include several agents responsible for severe hemorrhagic fevers.
Yuxi Wen +11 more
doaj +1 more source
Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production
Frontiers in Microbiology, 2020 Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo +6 more
doaj +1 more source
Uirusu, 2012 Arenaviruses are the collective name for viruses, which belong to the family Arenaviridae. They replicate in the cytoplasm of cells, and were named after the sandy (Latin, arenosus) appearance of the ribosomes often seen in thin sections of virions under electron microscope. Several arenaviruses, such as Lassa virus in West Africa, and Junin, Guanarito,
TANI, Hideki +4 more
openaire +3 more sources
Reporter-Expressing, Replicating-Competent Recombinant Arenaviruses
Viruses, 2016 Several arenaviruses cause hemorrhagic fever (HF) disease in humans and pose an important public health problem in their endemic regions. To date, no Food and Drug Administration (FDA)-licensed vaccines are available to combat human arenavirus infections,
Luis Martínez-Sobrido +1 more
doaj +1 more source