Results 11 to 20 of about 4,874 (174)
Advances in Virology, 2011 Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus-host interactions
Shuzo Urata, Juan Carlos de la Torre
doaj +4 more sources
Molecular characterization of arenavirus defective viral genomes reveals sequence features associated with their formation [PDF]
Journal of VirologyDefective viral genomes (DVGs) are byproducts of replication that arise during infection with diverse RNA viruses and can impact virus infection and disease outcome.
Thomas Hoenen +5 more
doaj +2 more sources
Emerging Infectious Diseases, 2011 To investigate arenavirus in Zambia, we characterized virus from the kidneys of 5 arenavirus RNA–positive rodents (Mastomys natalensis) among 263 captured.
Akihiro Ishii +8 more
doaj +3 more sources
Vaccine Candidates against Arenavirus Infections
Vaccines, 2023 The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Takeshi Saito +2 more
exaly +3 more sources
Animal Models, Prophylaxis, and Therapeutics for Arenavirus Infections
Viruses, 2012 Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever.
Eric Vela
exaly +3 more sources
Pathogenesis of arenavirus hemorrhagic fevers [PDF]
Expert Review of Anti-Infective Therapy, 2011 Viral hemorrhagic fevers (VHFs) caused by arenaviruses belong to the most devastating emerging human diseases and represent serious public health problems. Arenavirus VHFs in humans are acute diseases characterized by fever and, in severe cases, different degrees of hemorrhages associated with a shock syndrome in the terminal stage. Over the past years,
Stefan Kunz
exaly +3 more sources
Characterization of non-standard viral genomes during arenavirus infections identifies prominent S RNA intergenic region deletions [PDF]
mBioArenaviruses, a family of negative-sense RNA viruses spread by rodents, are a leading cause of severe hemorrhagic fever in humans. Due to a paucity of antivirals and vaccines for arenaviruses, there is a need to identify new mechanisms for interfering ...
Matthew Hackbart, Carolina B. López
doaj +2 more sources
Virology, 2011 Several arenaviruses, chiefly Lassa virus, cause hemorrhagic fever disease in humans and pose a significant public health problem in their endemic regions. On the other hand the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus-host interactions and associated disease.
Shuzo Urata, Juan CARLOS De La Torre
exaly +3 more sources
Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates [PDF]
VaccinesArenavirus-based vectors are being investigated as therapeutic vaccine candidates with the potential to elicit robust CD8 T-cell responses. We compared the immunogenicity of replicating (artPICV and artLCMV) and non-replicating (rPICV and rLCMV ...
Bhawna Sharma +19 more
doaj +2 more sources
Molecular Mechanism of Arenavirus Assembly and Budding [PDF]
Viruses, 2012 Arenaviruses have a bisegmented negative-strand RNA genome, which encodes four viral proteins: GP and NP by the S segment and L and Z by the L segment. These four viral proteins possess multiple functions in infection, replication and release of progeny viruses from infected cells. The small RING finger protein, Z protein is a matrix protein that plays
Shuzo Urata, Jiro Yasuda, Urata Shuzo
exaly +4 more sources