Results 41 to 50 of about 4,888 (173)

Envelope Glycoprotein of Arenaviruses

Viruses, 2012
Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets for ...
Antonella Pasquato, Stefan Kunz, Dominique J. Burri, Joel Ramos da Palma   +3 more
doaj   +1 more source

Research Direction and Science Evaluation: The Role of Coherence and Alignment

Journal of Economics &Management Strategy, Volume 35, Issue 3, Page 437-474, Fall 2026.
ABSTRACT The decisions of funding agencies greatly influence the direction of scientific research; however, our understanding of how applicants' research directions affect the selection process remains limited. In this study, we investigate how a project's coherence with a scientist's previous work and its alignment with current scientific trends ...
Charles Ayoubi, Sandra Barbosu, Michele Pezzoni, Fabiana Visentin   +3 more
wiley   +1 more source

Molecular Detection and Genetic Characterization of Novel RNA Viruses in Wild and Synanthropic Rodents and Shrews in Kenya

Frontiers in Microbiology, 2019
The majority of emerging and reemerging zoonotic viral pathogens are RNA viruses. Pathogen discovery programs of emerging infectious diseases (EIDs) in wildlife have implicated rodents and shrews as hosts of diverse human pathogens, such as hantaviruses,
Samson Omondi Onyuok, Samson Omondi Onyuok, Samson Omondi Onyuok, Samson Omondi Onyuok, Ben Hu, Ben Hu, Ben Hu, Bei Li, Yi Fan, Kelvin Kering, Kelvin Kering, Griphin Ochieng Ochola, Griphin Ochieng Ochola, Griphin Ochieng Ochola, Griphin Ochieng Ochola, Xiao-Shuang Zheng, Vincent Obanda, Sheila Ommeh, Xing-Lou Yang, Xing-Lou Yang, Xing-Lou Yang, Bernard Agwanda, Zheng-Li Shi, Zheng-Li Shi, Zheng-Li Shi   +24 more
doaj   +1 more source

BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis.

PLoS Pathogens, 2020
Pathogenicity often differs dramatically among even closely related arenavirus species. For instance, Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is closely related to Tacaribe virus (TCRV), which is normally avirulent ...
Julia Holzerland, Lucie Fénéant, Logan Banadyga, Julia E Hölper, Michael R Knittler, Allison Groseth   +5 more
doaj   +1 more source

Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation

European Journal of Immunology, Volume 56, Issue 6, June 2026.
• pDCs are defined by high surface TFRC expression and dynamic iron flux, distinguishing them from conventional dendritic cell subsets. • In the Iron proteome, pDC are enriched for mitochondrial heme and Fe–S proteins but have similar iron storage to cDC. • Iron chelation does not disrupt pDC type‐1 IFN production. ABSTRACT Plasmacytoid dendritic cells
Carrie Corkish, Simon O'Shaughnessy, Claire Lin, Sophia Wugk, Sarah Kenny, Linda Sinclair, Suzanne Cloonan, David Finlay   +7 more
wiley   +1 more source

Recent Discoveries of Novel Mammarenaviruses Infecting Humans and Other Mammals in Asia and Southeast Asia

Virulence, 2023
Mammarenaviruses, a genus of the family Arenaviridae, are capable of infecting mammals and are primarily found in rodent reservoirs worldwide. Mammarenaviruses can be transmitted to humans through contact with infected rodents, and though infection is ...
Brigitte Flannery, Michaela Cain, Hinh Ly   +2 more
doaj   +1 more source

Arenavirus research and antiviral candidate

Uirusu, 2018
Arenavirus is a genetic term for viruses belonging to the family Arenaviridae and is presented from lymphocytic choriomeningitis virus (LCMV), which shows almost no pathogenicity to humans, to Lassa virus, Junin virus, Machupo virus, Chapare virus, Lujo virus, Sabia virus, and Guanarito virus, which shows high pathogenicity to humans.
Hideki, Tani, Urata, Shuzo
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, Volume 600, Issue 10, Page 1420-1443, May 2026.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Viral RNA and infectious virus in mucosal specimens from guinea pigs modelling early phases of lethal and non-lethal Lassa fever

Emerging Microbes and Infections, 2022
Lassa fever (LF) is endemic to broad regions of West Africa. Infection with Lassa virus (LASV), the etiologic agent of LF, results in a spectrum of clinical signs in humans, including severe and lethal hemorrhagic disease.
Stephen R. Welch, Sarah C. Genzer, JoAnn D. Coleman-McCray, Jessica R. Harmon, Florine E.M. Scholte, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler   +7 more
doaj   +1 more source