Results 61 to 70 of about 8,211 (209)

Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression [PDF]

, 2017
Junin virus (JUNV), a highly pathogenic New World arenavirus, is the causative agent of Argentine hemorrhagic fever (AHF). The live-attenuated Candid #1 (Can) strain currently serves as a vaccine for at-risk populations. We have previously shown that the
Alexey V. Seregin, Cheng Huang, John T. Manning, José Barral, Juan C. de la Torre, Nadezhda E. Yun, Slobodan Paessler, Takaaki Koma   +7 more
core   +1 more source

Suppression of Calcium Influx Reduces Coxsackievirus B3 Lethality With Elevated Interferon Beta Responses in Mice

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT The disease course of severe enterovirus (EV) infection with hepatic necrosis is usually fulminant and fatal. Coxsackievirus (CVB3) is the emerging and important serotype of newborn EV inducing hepatic necrosis. Calcium (Ca2+) regulates host immunity, type I interferon (IFN‐I), and viral infections.
Yi‐Ling Hsiao, Cheng‐Huei Hung, Ming Te Yeh, Shun‐Hua Chen   +3 more
wiley   +1 more source

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Entry inhibitors as arenavirus antivirals. [PDF]

Front Microbiol
Arenaviruses belonging to the Arenaviridae family, genus mammarenavirus, are enveloped, single-stranded RNA viruses primarily found in rodent species, that cause severe hemorrhagic fever in humans. With high mortality rates and limited treatment options, the search for effective antivirals is imperative.
Iyer K, Yan Z, Ross SR.
europepmc   +4 more sources

Production of CXC and CC chemokines by human antigen-presenting cells in response to Lassa virus or closely related immunogenic viruses, and in cynomolgus monkeys with lassa fever. [PDF]

, 2014
International audienceThe pathogenesis of Lassa fever (LF), a hemorrhagic fever endemic to West Africa, remains unclear. We previously compared Lassa virus (LASV) with its genetically close, but nonpathogenic homolog Mopeia virus (MOPV) and demonstrated ...
A Mantovani, A Wack, B Moser, C Pythoud, C-L Lin, D Cook, D Pannetier, D Pannetier, D Whiting, DD Pinschewer, DD Taub, DD Taub, DD Taub, Delphine Pannetier, DH Walker, DH Walker, F Castellino, H Sung Jung, H Wulff, IS Lukashevich, J ter Meulen, J ter Meulen, JB McCormick, JB McCormick, JE Christensen, JF Foley, JH Dufour, JR Groom, KM Hastie, KM Johnson, L Hensley, L Martinez-Sobrido, L Martinez-Sobrido, LL Xu, M Habjan, M Inngjerdingen, M Liu, M Loetscher, M Macal, M Perez, M Russier, M-F Hsieh, Marion Russier, MD Bowen, MM Djavani, MP Kiley, N Sogoba, O Lenz, R Lande, S Baize, S Baize, S Baize, S Deshmane, S Günther, S Mahanty, S Mahanty, S Malhotra, SL Ruo, Stéphanie Reynard, Sylvain Baize, T Strecker, Thomas Geisbert, TI Cornu, TJ Schall, W Cao, WWSI Rodrigo, X Carnec, X Qi, Xavier Carnec   +68 more
core   +5 more sources

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Geographic Distribution and Genetic Diversity of Whitewater Arroyo Virus in the Southwestern United States

Emerging Infectious Diseases, 2001
The purpose of this study was to extend our knowledge of the geographic distribution and genetic diversity of the arenavirus(es) associated with Neotoma species (woodrats) in the southwestern United States.
Charles F. Fulhorst, Remi N. Charrel, Scott C. Weaver, Thomas G. Ksiazek, Robert D. Bradley, Mary L. Milazzo, Robert B. Tesh, Michael D. Bowen   +7 more
doaj   +1 more source

Post-translational processing of the glycoproteins of lymphocytic choriomeningitis virus. [PDF]

, 1990
Intracellular events in the synthesis, glycosylation, and transport of the lymphocytic choriomeningitis virus (LCMV) glycoproteins have been examined. We have shown by N-glycanase digestion that LCMV strain Arm-4 bears five oligosaccharides on GP-1 and ...
Buchmeier, MJ, Burns, JW, Spiro, RC, Wright, KE   +3 more
core  

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection.

PLoS Pathogens, 2015
Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans. As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb) responses represent a unifying characteristic of both natural infection and ...
Rami Sommerstein, Lukas Flatz, Melissa M Remy, Pauline Malinge, Giovanni Magistrelli, Nicolas Fischer, Mehmet Sahin, Andreas Bergthaler, Sebastien Igonet, Jan Ter Meulen, Dorothée Rigo, Paolo Meda, Nadia Rabah, Bruno Coutard, Thomas A Bowden, Paul-Henri Lambert, Claire-Anne Siegrist, Daniel D Pinschewer   +17 more
doaj   +1 more source