Results 51 to 60 of about 7,989 (190)

Endangered wild salmon infected by newly discovered viruses

eLife, 2019
The collapse of iconic, keystone populations of sockeye (Oncorhynchus nerka) and Chinook (Oncorhynchus tshawytscha) salmon in the Northeast Pacific is of great concern. It is thought that infectious disease may contribute to declines, but little is known
Gideon J Mordecai, Kristina M Miller, Emiliano Di Cicco, Angela D Schulze, Karia H Kaukinen, Tobi J Ming, Shaorong Li, Amy Tabata, Amy Teffer, David A Patterson, Hugh W Ferguson, Curtis A Suttle   +11 more
doaj   +1 more source

Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment

Journal for ImmunoTherapy of Cancer
Background Engineered arenavirus vectors have recently been developed to leverage the body’s immune system in the fight against chronic viral infections and cancer. Vectors based on Pichinde virus (artPICV) and lymphocytic choriomeningitis virus (artLCMV)
J. Raguz, Catarina Pinto, T. Pölzlbauer, M. Habbeddine, Sandra Rosskopf, Judith Strauss, Valentin Just, S. Schmidt, Katell Bidet Huang, Felix Stemeseder, Timo Schippers, Ethan Stewart, Jakub Jeż, P. Berraondo, K. Orlinger, H. Lauterbach   +15 more
semanticscholar   +1 more source

Structural and functional studies of novel mechanisms of Lassa fever virus nucleoprotein in immune suppression, viral RNA transcription and replication [PDF]

, 2013
Lassa fever virus is one of the most dangerous viruses of arenaviridae family, causing more than 500,000 infections per year in Africa. The fatality rate for hospitalized patients is as high as 20%.
Qi, Xiaoxuan
core   +2 more sources

Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform

Viruses, 2021
Lujo virus (LUJV), a highly pathogenic arenavirus, was first identified in 2008 in Zambia. To aid the identification of effective therapeutics for LUJV, we developed a recombinant reporter virus system, confirming reporter LUJV comparability with wild ...
Stephen R. Welch, Jessica R. Spengler, Sarah C. Genzer, Payel Chatterjee, Mike Flint, Éric Bergeron, Joel M. Montgomery, Stuart T. Nichol, César G. Albariño, Christina F. Spiropoulou   +9 more
doaj   +1 more source

Lymphocytic choriomeningitis arenavirus utilises intercellular connections for cell to cell spread

Scientific Reports
The Arenaviridae family of segmented RNA viruses contains nearly 70 species with several associated with fatal haemorrhagic fevers, including Lassa, Lujo and Junin viruses.
Owen Byford, A. Shaw, Hiu Nam Tse, Alex Moon-Walker, E. Saphire, Sean P. J. Whelan, Martin Stacey, Roger Hewson, Juan Fontana, J. Barr   +9 more
semanticscholar   +1 more source

Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract CD8 T cells and the process of T cell exhaustion are central topics in both basic immunology and translational research, including clinical applications. Here, we provide a comprehensive, step‐by‐step guide to investigate CD8 T cells in murine in vivo lymphocytic choriomeningitis virus (LCMV) infection models.
Dominique Stark, Marie‐Elen Tuchel, Gautier Stehli, Alessandro Genovese, Isaak Quast, Annette Oxenius   +5 more
wiley   +1 more source

Envelope Glycoprotein of Arenaviruses

Viruses, 2012
Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets for ...
Antonella Pasquato, Stefan Kunz, Dominique J. Burri, Joel Ramos da Palma   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Molecular Detection and Genetic Characterization of Novel RNA Viruses in Wild and Synanthropic Rodents and Shrews in Kenya

Frontiers in Microbiology, 2019
The majority of emerging and reemerging zoonotic viral pathogens are RNA viruses. Pathogen discovery programs of emerging infectious diseases (EIDs) in wildlife have implicated rodents and shrews as hosts of diverse human pathogens, such as hantaviruses,
Samson Omondi Onyuok, Samson Omondi Onyuok, Samson Omondi Onyuok, Samson Omondi Onyuok, Ben Hu, Ben Hu, Ben Hu, Bei Li, Yi Fan, Kelvin Kering, Kelvin Kering, Griphin Ochieng Ochola, Griphin Ochieng Ochola, Griphin Ochieng Ochola, Griphin Ochieng Ochola, Xiao-Shuang Zheng, Vincent Obanda, Sheila Ommeh, Xing-Lou Yang, Xing-Lou Yang, Xing-Lou Yang, Bernard Agwanda, Zheng-Li Shi, Zheng-Li Shi, Zheng-Li Shi   +24 more
doaj   +1 more source

Mathematical Modeling of Pulse‐Seeded Metapopulation Dynamics for Andes Hantavirus Border Dispersal

Engineering Reports, Volume 8, Issue 9, September 2026.
A pulse‐seeded metapopulation SEIR model for Andes hantavirus maritime dispersal shows that heterogeneous quarantine compliance determines secondary outbreak risk. The weakest‐compliance country governs global containment, while uniform compliance above ∼65%$$ \sim 65\% $$ reduces the global reproduction number below unity.
Gideon K. Gogovi, Paul Chataa
wiley   +1 more source