Results 71 to 80 of about 7,989 (190)

Entry inhibitors as arenavirus antivirals

Frontiers in Microbiology
Arenaviruses belonging to the Arenaviridae family, genus mammarenavirus, are enveloped, single-stranded RNA viruses primarily found in rodent species, that cause severe hemorrhagic fever in humans. With high mortality rates and limited treatment options,
Kruthika Iyer, Zhong Yan, Susan R. Ross
semanticscholar   +1 more source

The board is set, the pieces are moving: Modulation of New World arenavirus entry by host proteins

PLoS Pathogens, 2021
Arenaviruses are enveloped viruses with 2 ambisense genomic RNA molecules, whose entry into cells is mediated by the viral glycoprotein (GP), generated by proteolytic processing of the precursor GPC into the subunits GP1 (the receptor-binding domain ...
Nicolás Sarute, S. Ross
semanticscholar   +1 more source

A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease.

PLoS Pathogens, 2009
Arenaviruses are the causative pathogens of severe hemorrhagic fever and aseptic meningitis in humans, for which no licensed vaccines are currently available. Pathogen heterogeneity within the Arenaviridae family poses a significant challenge for vaccine
Maya F Kotturi, Jason Botten, John Sidney, Huynh-Hoa Bui, Lori Giancola, Matt Maybeno, Josie Babin, Carla Oseroff, Valerie Pasquetto, Jason A Greenbaum, Bjoern Peters, Joey Ting, Danh Do, Lo Vang, Jeff Alexander, Howard Grey, Michael J Buchmeier, Alessandro Sette   +17 more
doaj   +1 more source

Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. [PDF]

PLoS Pathogens, 2009
Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial ...
Thomas Briese, Janusz T Paweska, Laura K McMullan, Stephen K Hutchison, Craig Street, Gustavo Palacios, Marina L Khristova, Jacqueline Weyer, Robert Swanepoel, Michael Egholm, Stuart T Nichol, W Ian Lipkin   +11 more
doaj   +1 more source

Arenavirus Induced CCL5 Expression Causes NK Cell-Mediated Melanoma Regression

Frontiers in Immunology, 2020
Immune activation within the tumor microenvironment is one promising approach to induce tumor regression. Certain viruses including oncolytic viruses such as the herpes simplex virus (HSV) and non-oncolytic viruses such as the lymphocytic ...
H. Bhat, G. Zaun, T. Hamdan, Judith Lang, Tom Adomati, Rosa Schmitz, Sarah-Kim Friedrich, Michael Bergerhausen, Lamin B. Cham, Fang-Hui Li, Murtaza Ali, Fan Zhou, V. Khairnar, V. Duhan, Tim Brandenburg, Y. Machlah, Maximilian Schiller, Arshia Berry, Hai-Feng C. Xu, J. Vollmer, D. Häussinger, Beatrice Thier, A. Pandyra, D. Schadendorf, A. Paschen, M. Schuler, P. Lang, K. Lang   +27 more
semanticscholar   +1 more source

Suppression of Calcium Influx Reduces Coxsackievirus B3 Lethality With Elevated Interferon Beta Responses in Mice

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT The disease course of severe enterovirus (EV) infection with hepatic necrosis is usually fulminant and fatal. Coxsackievirus (CVB3) is the emerging and important serotype of newborn EV inducing hepatic necrosis. Calcium (Ca2+) regulates host immunity, type I interferon (IFN‐I), and viral infections.
Yi‐Ling Hsiao, Cheng‐Huei Hung, Ming Te Yeh, Shun‐Hua Chen   +3 more
wiley   +1 more source

Biochemical reconstitution of hemorrhagic-fever arenavirus envelope glycoprotein-mediated membrane fusion. [PDF]

PLoS ONE, 2012
The membrane-anchored proteins of enveloped viruses form labile spikes on the virion surface, primed to undergo large-scale conformational changes culminating in virus-cell membrane fusion and viral entry.
Celestine J Thomas, Sundaresh Shankar, Hedi E Casquilho-Gray, Joanne York, Stephen R Sprang, Jack H Nunberg   +5 more
doaj   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

AP‐1‐Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Vasily N. Sukhorukov, Amin Jalili, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

A subpopulation of arenavirus nucleoprotein localizes to mitochondria

Scientific Reports, 2021
Viruses need cells for their replication and, therefore, ways to hijack cellular functions. Mitochondria play fundamental roles within the cell in metabolism, immunity and regulation of homeostasis due to which some viruses aim to alter mitochondrial ...
F. Baggio, U. Hetzel, L. Nufer, A. Kipar, J. Hepojoki   +4 more
semanticscholar   +1 more source