Results 91 to 100 of about 8,211 (209)

The Lassa Virus Stable Signal Peptide Undergoes a Conformational Change to Aid Viral Fusion

Chemistry – A European Journal, Volume 31, Issue 18, March 25, 2025.
The unique stable signal peptide (SSP) of the Lassa virus glycoprotein complex undergoes a conformational change during pH‐dependent viral fusion. This revels a potential mechanism by which the enigmatic SSP influences the fusion process through interactions it makes with the fusion protein, glycoprotein 2 (GP2).
Shane D. Collins, Liqun Jiang, Yanxin Liu, Jinwoo Lee   +3 more
wiley   +1 more source

Sabiá Virus–Like Mammarenavirus in Patient with Fatal Hemorrhagic Fever, Brazil, 2020

Emerging Infectious Diseases, 2020
New World arenaviruses can cause chronic infection in rodents and hemorrhagic fever in humans. We identified a Sabiá virus–like mammarenavirus in a patient with fatal hemorrhagic fever from São Paulo, Brazil.
Fernanda de Mello Malta, Deyvid Amgarten, Ana Catharina de Seixas Santos Nastri, Yeh-Li Ho, Luciana Vilas Boas Casadio, Marcela Basqueira, Gloria Selegatto, Murilo Castro Cervato, Amaro Nunes Duarte-Neto, Hermes Ryoiti Higashino, Felipe Arthur Faustino Medeiros, José Luiz Pinto Lima Gendler, Anna S. Levin, João Renato Rebello Pinho   +13 more
doaj   +1 more source

Analyzing Machupo virus-receptor binding by molecular dynamics simulations [PDF]

, 2014
In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein-protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases.
Ellington, Andrew D., Meyer, Austin G., Sawyer, Sara L., Wilke, Claus O.   +3 more
core   +2 more sources

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components

WIREs RNA, Volume 16, Issue 2, March/April 2025.
Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus, Eliana Dukhno, Rupali Kapoor, Piotr Gerlach   +3 more
wiley   +1 more source

Replicating viral vector platform exploits alarmin signals for potent CD8⁺ T cell-mediated tumour immunotherapy. [PDF]

, 2017
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL ^eff ) responses. Conversely, the induction of protective tumour-specific CTL ^eff and their recruitment into the
A Hyvarinen, A Plyusnin, A Wortmann, AM Henao-Restrepo, C Baumann, C Butts, CA Klebanoff, CB Stephensen, D Peng, D Valmori, D Zamarin, DA Enria, DK Reichenbach, DL Popkin, E Scandella, ER Chare, F Duan, F Pages, F Spertini, GP Dunn, HE Webb, J Delaloye, J Liu, J Zhu, JA Joyce, JF Vansteenkiste, JY Liu, K Oboki, KM Quinn, L Flatz, L Flatz, L Flatz, L Zhang, LC Anton, M Lewandoski, M Peine, M Perez, M Suter, M Vanneman, MD Stenglein, MF Callan, MF Kotturi, MJ Townsend, N Fasnacht, O Kew, P Grob, P Sharma, PC Doherty, PC Tumeh, PW Kantoff, R Schirmbeck, R Sommerstein, RH Andtbacka, RM Zinkernagel, RM Zinkernagel, S Darbre, S Spranger, SA Fuertes Marraco, SA Rosenberg, SF Emonet, SG Hansen, SN Mueller, T Querec, TF Gajewski, TN Schumacher, WV Bonilla, WV Bonilla, X de Lamballerie, Y Iwai, Z Waibler   +69 more
core   +2 more sources

Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions

Advanced Science, Volume 12, Issue 3, January 20, 2025.
Live attenuated vaccines represent a delicate equilibrium between virulence and immunogenicity during adaptation. The process of animal adaptation involves artificial selection; therefore, adapted viruses exhibit decreased pathogenicity to their original hosts and increased pathogenicity to their adapted hosts.
Yan‐Dong Tang, Yuming Li, Xue‐Hui Cai, Xin Yin   +3 more
wiley   +1 more source

Characterization of Junín arenavirus cell entry

Journal of General Virology, 2007
Junín virus (JUNV) entry is conducted by receptor-mediated endocytosis. To explore the cellular entry mechanism of JUNV, inhibitory effects of drugs affecting the main endocytic pathways on JUNV entry into Vero cells were analysed. Compounds that impair clathrin-mediated endocytosis were shown to reduce virus internalization without affecting virion ...
M Guadalupe, Martinez, Sandra M, Cordo, Nélida A, Candurra   +2 more
openaire   +2 more sources

Population dynamic of porcine parvovirus indicates decrease of variability [PDF]

, 2013
Projeto/Plano de Ação: 02.11.10.600 ...
FOESTER, T., GAVA, D., HOMEIER, T., STRECK, A. F., TRUYEN, U.   +4 more
core  

Arbovirus infections and viral haemorrhagic fevers in Uganda : a serological survey in Karamoja district, 1984 [PDF]

, 1989
Présentation des résultats de l'enquête effectuée sur 132 habitants du district de Karamoja en Ouganda, qui ont été examinés pour la recherche d'anticorps contre certains arbovirus dont la fièvre ...
Gonzalez, Jean-Paul, Hannoun, C., Helynck, B., Larouze, B., Mercier, E., Rodhain, F.   +5 more
core   +1 more source

Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes [PDF]

, 2017
Arenaviruses such as Lassa virus (LASV) cause significant morbidity and mortality in endemic areas. Using a glycoprotein (GP) exchange strategy, we have recently developed live-attenuated arenavirus vaccine prototypes (rLCMV/VSVG) based on lymphocytic ...
Bergthaler, Andreas, Fernandez, Marylise, Flatz, Lukas, Horvath, Edit, Lutz, Hans, Pinschewer, Daniel D., Steinborn, Ralf, Suter, Mark   +7 more
core