Results 31 to 40 of about 4,888 (173)

The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion.

PLoS Pathogens, 2021
Arenavirus entry into host cells occurs through a low pH-dependent fusion with late endosomes that is mediated by the viral glycoprotein complex (GPC). The mechanisms of GPC-mediated membrane fusion and of virus targeting to late endosomes are not well ...
Ruben M Markosyan, Mariana Marin, You Zhang, Fredric S Cohen, Gregory B Melikyan   +4 more
doaj   +1 more source

DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection.

PLoS Pathogens, 2018
Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which countermeasures are urgently needed ...
María Eugenia Loureiro, Andre Luiz Zorzetto-Fernandes, Sheli Radoshitzky, Xiaoli Chi, Simone Dallari, Nuha Marooki, Psylvia Lèger, Sabrina Foscaldi, Vince Harjono, Sonia Sharma, Brian M Zid, Nora López, Nora López, Juan Carlos de la Torre, Sina Bavari, Elina Zúñiga   +15 more
doaj   +1 more source

Pathogenesis of arenavirus hemorrhagic fevers [PDF]

Expert Review of Anti-infective Therapy, 2011
Viral hemorrhagic fevers (VHFs) caused by arenaviruses belong to the most devastating emerging human diseases and represent serious public health problems. Arenavirus VHFs in humans are acute diseases characterized by fever and, in severe cases, different degrees of hemorrhages associated with a shock syndrome in the terminal stage. Over the past years,
Moraz ML, Kunz S
openaire   +3 more sources

Diagnóstico virológico y molecular de virus transmitidos por roedores. Hantavirus y arenavirus [PDF]

Revista Mvz Cordoba, 2010
Los hantavirus (familia Bunyaviridae) y arenavirus (familia Arenaviridae) son virus de roedores; cada uno de ellos parece estar estrictamente asociado con una especie de roedor en la que causa una infección persistente y asintomática.
Silvana Levis
doaj  

Mopeia Virus–related Arenavirus in Natal Multimammate Mice, Morogoro, Tanzania

Emerging Infectious Diseases, 2009
A serosurvey involving 2,520 small mammals from Tanzania identified a hot spot of arenavirus circulation in Morogoro. Molecular screening detected a new arenavirus in Natal multimammate mice (Mastomys natalensis), Morogoro virus, related to Mopeia virus.
Stephan Günther, Guy Hoofd, Remi Charrel, Christina Röser, Beate Becker-Ziaja, Graham Lloyd, Christopher Sabuni, Ron Verhagen, Guido van der Groen, Jan Kennis, Abdul Katakweba, Rhodes Makundi, Herwig Leirs   +12 more
doaj   +1 more source

Endangered wild salmon infected by newly discovered viruses

eLife, 2019
The collapse of iconic, keystone populations of sockeye (Oncorhynchus nerka) and Chinook (Oncorhynchus tshawytscha) salmon in the Northeast Pacific is of great concern. It is thought that infectious disease may contribute to declines, but little is known
Gideon J Mordecai, Kristina M Miller, Emiliano Di Cicco, Angela D Schulze, Karia H Kaukinen, Tobi J Ming, Shaorong Li, Amy Tabata, Amy Teffer, David A Patterson, Hugh W Ferguson, Curtis A Suttle   +11 more
doaj   +1 more source

Arenavirus Concentration by Molecular Filtration [PDF]

Applied and Environmental Microbiology, 1977
Liter volumes of a human arenavirus pathogen (Machupo) and a nonpathogen (Tacaribe) were concentrated 30 to 100 times in less than 90 min without significant loss of particle infectivity.
J D, Gangemi, E V, Connell, B G, Mahlandt, G A, Eddy   +3 more
openaire   +2 more sources

New arenavirus isolated in Brazil [PDF]

The Lancet, 1994
A new arenavirus, called Sabiá, was isolated in Brazil from a fatal case of haemorrhagic fever initially thought to be yellow fever. Antigenic and molecular characterisation indicated that Sabiá virus is a new member of the Tacaribe complex. A laboratory technician working with the agent was also infected and developed a prolonged, non-fatal influenza ...
Coimbra, T.L.M., Nassar, E.S., Burattini, M.N., Madia de Souza, L.T., Ferreira, I.B., Rocco, I.M., Travassos da Rosa, A.P.A., Vasconcelos, P.F.C., Pinheiro, F.P., Le Duc, J.W., Rico-Hesse, R., /Gonzalez, Jean-Paul, Jahrling, P.B., Tesh, R.B.   +13 more
openaire   +3 more sources

Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform

Viruses, 2021
Lujo virus (LUJV), a highly pathogenic arenavirus, was first identified in 2008 in Zambia. To aid the identification of effective therapeutics for LUJV, we developed a recombinant reporter virus system, confirming reporter LUJV comparability with wild ...
Stephen R. Welch, Jessica R. Spengler, Sarah C. Genzer, Payel Chatterjee, Mike Flint, Éric Bergeron, Joel M. Montgomery, Stuart T. Nichol, César G. Albariño, Christina F. Spiropoulou   +9 more
doaj   +1 more source

Putting Rodents at the Center of One Health Programs: A Narrative Synthesis

Integrative Zoology, EarlyView.
Rodents link human, animal, and environmental health across diverse ecosystems. Rodent diversity underpins both zoonotic disease risk and ecosystem function. Environmental change reshapes rodent communities and spillover dynamics. Rodents act as reservoirs, amplifiers, and sentinels of emerging pathogens.
Steven R. Belmain
wiley   +1 more source