Results 31 to 40 of about 4,874 (174)

Distinct Molecular Mechanisms of Host Immune Response Modulation by Arenavirus NP and Z Proteins

Viruses, 2020
Endemic to West Africa and South America, mammalian arenaviruses can cross the species barrier from their natural rodent hosts to humans, resulting in illnesses ranging from mild flu-like syndromes to severe and fatal haemorrhagic zoonoses. The increased
Robert J. Stott, Thomas Strecker, Toshana L. Foster   +2 more
doaj   +1 more source

Standardization of an ELISA test using a recombinant nucleoprotein from the Junin virus as the antigen and serological screening for arenavirus among the population of Nova Xavantina, State of Mato Grosso Padronização de um teste de ELISA utilizando a nucleoproteína recombinante de vírus Junin como antígeno e triagem sorológica para Arenavírus na população de Nova Xavantina, Estado do Mato Grosso

Revista da Sociedade Brasileira de Medicina Tropical, 2010
INTRODUCTION: Arenavirus hemorrhagic fever is a severe emerging disease. METHODS: Considering that the levels of antibodies against arenavirus in the Brazilian population are completely unknown, we have standardized an ELISA test for detecting IgG ...
Alex Martins Machado, Glauciane Garcia Figueiredo, Gelse Maria Campos, Mario Enrique Lozano, Aline Rafaela da Silva Rodrigues Machado, Luiz Tadeu Moraes Figueiredo   +5 more
doaj   +1 more source

Phylogeny of the genus Arenavirus

Current Opinion in Microbiology, 2008
The family Arenaviridae consists of a unique genus (Arenavirus) that currently comprises 22 viral species, as recognized by the International Committee for Taxonomy of Viruses. Seven newly discovered represent putative new species. Here, our aims were to provide the most comprehensive phylogenetic analysis of members and putative members of the family ...
Charrel, R. N., /Lamballerie de, Xavier, Emonet, S.   +2 more
openaire   +3 more sources

Arenavirus Phylogeny: A New Insight

Virus Genes, 1998
Arenaviridae is a worldwide distributed family, of enveloped, single stranded, RNA viruses. The arenaviruses were divided in two major groups (Old World and New World), based on serological properties and genetic data, as well as the geographic distribution. In this study the phylogenetic relationship among the members of the Arenaviridae was examined,
Albariño, César G., Posik, Diego Manuel, Ghiringhelli, Pablo Daniel, Lozano, Mario Enrique, Romanowski, Víctor   +4 more
openaire   +3 more sources

Envelope exchange for the generation of live-attenuated arenavirus vaccines. [PDF]

PLoS Pathogens, 2006
Arenaviruses such as Lassa fever virus cause significant mortality in endemic areas and represent potential bioterrorist weapons. The occurrence of arenaviral hemorrhagic fevers is largely confined to Third World countries with a limited medical ...
Andreas Bergthaler, Nicolas U Gerber, Doron Merkler, Edit Horvath, Juan Carlos de la Torre, Daniel D Pinschewer   +5 more
doaj   +2 more sources

Serological Assays Based on Recombinant Viral Proteins for the Diagnosis of Arenavirus Hemorrhagic Fevers

Viruses, 2012
The family Arenaviridae, genus Arenavirus, consists of two phylogenetically independent groups: Old World (OW) and New World (NW) complexes. The Lassa and Lujo viruses in the OW complex and the Guanarito, Junin, Machupo, Sabia, and Chapare viruses in the
Masayuki Saijo, Shigeru Morikawa, Tomoki Yoshikawa, Hideki Tani, Shuetsu Fukushi   +4 more
doaj   +1 more source

Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity

Frontiers in Microbiology, 2022
In the absence of effective vaccines and treatments, annual outbreaks of severe human haemorrhagic fever caused by arenaviruses, such as Lassa virus, continue to pose a significant human health threat.
Robert J. Stott-Marshall, Toshana L. Foster   +1 more
doaj   +1 more source

New arenavirus isolated in Brazil [PDF]

The Lancet, 1994
A new arenavirus, called Sabiá, was isolated in Brazil from a fatal case of haemorrhagic fever initially thought to be yellow fever. Antigenic and molecular characterisation indicated that Sabiá virus is a new member of the Tacaribe complex. A laboratory technician working with the agent was also infected and developed a prolonged, non-fatal influenza ...
Coimbra, T.L.M., Nassar, E.S., Burattini, M.N., Madia de Souza, L.T., Ferreira, I.B., Rocco, I.M., Travassos da Rosa, A.P.A., Vasconcelos, P.F.C., Pinheiro, F.P., Le Duc, J.W., Rico-Hesse, R., /Gonzalez, Jean-Paul, Jahrling, P.B., Tesh, R.B.   +13 more
openaire   +3 more sources

Seroprevalence of arenavirus and hantavirus in indigenous populations from the Caribbean, Colombia

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: In Colombia, there is insufficient epidemiological surveillance of zoonotic hemorrhagic viruses. METHODS: We performed a sero-epidemiological study in indigenous populations of Wayuü, Kankuamos, and Tuchin communities using Maciel ...
Amada Bolaños, Carolina Montoya-Ruiz, Juan Camilo Perez-Peréz, Juan David Rodas, Salim Mattar   +4 more
doaj   +1 more source

CP100356 Hydrochloride, a P-Glycoprotein Inhibitor, Inhibits Lassa Virus Entry: Implication of a Candidate Pan-Mammarenavirus Entry Inhibitor

Viruses, 2021
Lassa virus (LASV)—a member of the family Arenaviridae—causes Lassa fever in humans and is endemic in West Africa. Currently, no approved drugs are available.
Toru Takenaga, Zihan Zhang, Yukiko Muramoto, Sarah Katharina Fehling, Ai Hirabayashi, Yuki Takamatsu, Junichi Kajikawa, Sho Miyamoto, Masahiro Nakano, Shuzo Urata, Allison Groseth, Thomas Strecker, Takeshi Noda   +12 more
doaj   +1 more source