Results 31 to 40 of about 7,989 (190)

Effects of the Natural Flavonoid Quercetin on Arenavirus Junín Infection

Viruses, 2023
There is no specific chemotherapy approved for the treatment of pathogenic arenaviruses that cause severe hemorrhagic fever (HF) in the population of endemic regions in America and Africa.
Aaron Ezequiel Alvarez De Lauro, Miguel Ángel Peláez, A. Marquez, Mariel S Wagner, L. Scolaro, C. García, E. Damonte, C. Sepúlveda   +7 more
semanticscholar   +1 more source

Understanding Host–Virus Interactions: Assessment of Innate Immune Responses in Mastomys natalensis Cells after Arenavirus Infection

Viruses, 2022
Mastomys natalensis is the natural host of various arenaviruses, including the human-pathogenic Lassa virus. Homologous arenaviruses, defined here as those having M. natalensis as a natural host, can establish long-lasting infection in M.
Nele Marie Brinkmann, Chris Hoffmann, Stephanie Wurr, E. Pallasch, J. Hinzmann, E. Ostermann, W. Brune, Maria Elisabeth Eskes, Lukas Jungblut, S. Günther, Ludmilla Unrau, L. Oestereich   +11 more
semanticscholar   +1 more source

Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack

Cell Reports Medicine, 2021
Summary Therapeutic vaccination regimens inducing clinically effective tumor-specific CD8+ T lymphocyte (CTL) responses are an unmet medical need. We engineer two distantly related arenaviruses, Pichinde virus and lymphocytic choriomeningitis virus, for ...
Weldy V. Bonilla, N. Kirchhammer, Anna-Friederike Marx, S. Kallert, M. Krzyzaniak, Min Lu, Stephanie Darbre, S. Schmidt, J. Raguz, U. Berka, I. Vincenti, Mindaugas Paužuolis, R. Kerber, Sabine Hoepner, S. Günther, Carsten Magnus, D. Merkler, K. Orlinger, A. Zippelius, D. Pinschewer   +19 more
semanticscholar   +1 more source

Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity

PLoS Pathogens, 2021
Several arenaviruses cause hemorrhagic fevers in humans with high case fatality rates. A vaccine named Candid#1 is available only against Junin virus (JUNV) in Argentina.
T. Koma, Cheng Huang, A. Coscia, S. Hallam, John T. Manning, Junki Maruyama, Aida G Walker, Milagros Miller, Jeanon Smith, Michael Patterson, J. Abraham, S. Paessler   +11 more
semanticscholar   +1 more source

Reporter-Expressing, Replicating-Competent Recombinant Arenaviruses

Viruses, 2016
Several arenaviruses cause hemorrhagic fever (HF) disease in humans and pose an important public health problem in their endemic regions. To date, no Food and Drug Administration (FDA)-licensed vaccines are available to combat human arenavirus infections,
Luis Martínez-Sobrido, Juan Carlos de la Torre   +1 more
doaj   +1 more source

Development and Characterization of a Novel Non-Lytic Cancer Immunotherapy Using a Recombinant Arenavirus Vector Platform

Frontiers in Oncology, 2021
Engineered viral vectors represent a promising strategy to trigger antigen-specific antitumor T cell responses. Arenaviruses have been widely studied because of their ability to elicit potent and protective T cell responses.
H. Lauterbach, S. Schmidt, K. Katchar, Xiaoping Qing, C. Iacobucci, A. Hwang, K. Schlienger, U. Berka, J. Raguz, S. Ahmadi-Erber, Timo Schippers, Felix Stemeseder, D. Pinschewer, I. Matushansky, K. Orlinger   +14 more
semanticscholar   +1 more source

Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors

Bioorganic & Medicinal Chemistry Letters, 2021
We identified and explored the structure–activity relationship (SAR) of a novel heterocyclic chemical series of arenavirus cell entry inhibitors. Optimized lead compounds, including diphenyl-substituted imidazo[1,2-a]pyridines, benzimidazoles, and ...
M. Plewe, V. R. Gantla, N. V. Sokolova, Young-Jun Shin, Shibani Naik, E. Brown, Alexandra Fetsko, Li-Hong Zhang, Birte K. Kalveram, A. Freiberg, G. Henkel, Ken McCormack   +11 more
semanticscholar   +1 more source

Standardization of an ELISA test using a recombinant nucleoprotein from the Junin virus as the antigen and serological screening for arenavirus among the population of Nova Xavantina, State of Mato Grosso Padronização de um teste de ELISA utilizando a nucleoproteína recombinante de vírus Junin como antígeno e triagem sorológica para Arenavírus na população de Nova Xavantina, Estado do Mato Grosso

Revista da Sociedade Brasileira de Medicina Tropical, 2010
INTRODUCTION: Arenavirus hemorrhagic fever is a severe emerging disease. METHODS: Considering that the levels of antibodies against arenavirus in the Brazilian population are completely unknown, we have standardized an ELISA test for detecting IgG ...
Alex Martins Machado, Glauciane Garcia Figueiredo, Gelse Maria Campos, Mario Enrique Lozano, Aline Rafaela da Silva Rodrigues Machado, Luiz Tadeu Moraes Figueiredo   +5 more
doaj   +1 more source

Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay

Antiviral Research, 2022
Viral exoribonucleases are uncommon in the world of RNA viruses. To date, they have only been identified in the Arenaviridae and the Coronaviridae families. The exoribonucleases of these viruses play a crucial role in the pathogenicity and interplay with
Sergio Hernández, M. Feracci, Carolina Trajano De Jesus, Priscila El Kazzi, R. Kaci, L. Garlatti, Clémence Mondielli, Fabrice Bailly, P. Cotelle, F. Touret, X. D. de Lamballerie, B. Coutard, E. Decroly, B. Canard, F. Ferron, K. Alvarez   +15 more
semanticscholar   +1 more source

Structural basis for recognition and regulation of arenavirus polymerase L by Z protein

Nature Communications, 2021
Junin virus (JUNV) causes Argentine hemorrhagic fever, a debilitating human disease of high mortality rates and a great risk to public health worldwide.
Huiling Kang, Jingyuan Cong, Chenlong Wang, W. Ji, Yu Xin, Ying Qian, Xue-Mei Li, Yu-Tao Chen, Z. Rao   +8 more
semanticscholar   +1 more source