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Reverse Genetics Approaches to Control Arenavirus [PDF]
Methods in Molecular Biology, 2016 Several arenavirus cause hemorrhagic fever disease in humans and pose a significant public health problem in their endemic regions. To date, no licensed vaccines are available to combat human arenavirus infections, and anti-arenaviral drug therapy is limited to an off-label use of ribavirin that is only partially effective.
Luis Martinez-Sobrido +2 more
exaly +3 more sources
Entry inhibitors as arenavirus antivirals
Frontiers in MicrobiologyArenaviruses belonging to the Arenaviridae family, genus mammarenavirus, are enveloped, single-stranded RNA viruses primarily found in rodent species, that cause severe hemorrhagic fever in humans. With high mortality rates and limited treatment options, the search for effective antivirals is imperative.
Susan R Ross
exaly +4 more sources
Generation of Reporter-Expressing New World Arenaviruses: A Systematic Comparison
Viruses, 2022 Replication-competent reporter-expressing viruses are crucial tools in molecular virology with applications that range from antiviral screening to live-cell imaging of protein spatiotemporal dynamics.
Lucie Fénéant +3 more
doaj +1 more source
Viruses, 2022 Arenaviruses include important zoonotic pathogens that cause hemorrhagic fever (e.g., Junín virus; JUNV) as well as other viruses that are closely related but apathogenic (e.g., Tacaribe virus; TCRV).
Julia Holzerland +2 more
doaj +1 more source
Highly Diverse Arenaviruses in Neotropical Bats, Brazil
Emerging Infectious Diseases, 2022 We detected arenavirus RNA in 1.6% of 1,047 bats in Brazil that were sampled during 2007–2011. We identified Tacaribe virus in 2 Artibeus sp. bats and a new arenavirus species in Carollia perspicillata bats that we named Tietê mammarenavirus.
Luiz Gustavo Bentim Góes +14 more
doaj +1 more source
Visualizing lymphocytic choriomeningitis virus infection in cells and living mice
iScience, 2022 Summary: Mammarenavirus are a large family of enveloped negative-strand RNA viruses that include several agents responsible for severe hemorrhagic fevers.
Yuxi Wen +11 more
doaj +1 more source
Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production
Frontiers in Microbiology, 2020 Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo +6 more
doaj +1 more source
Uirusu, 2012 Arenaviruses are the collective name for viruses, which belong to the family Arenaviridae. They replicate in the cytoplasm of cells, and were named after the sandy (Latin, arenosus) appearance of the ribosomes often seen in thin sections of virions under electron microscope. Several arenaviruses, such as Lassa virus in West Africa, and Junin, Guanarito,
TANI, Hideki +4 more
openaire +3 more sources
Reporter-Expressing, Replicating-Competent Recombinant Arenaviruses
Viruses, 2016 Several arenaviruses cause hemorrhagic fever (HF) disease in humans and pose an important public health problem in their endemic regions. To date, no Food and Drug Administration (FDA)-licensed vaccines are available to combat human arenavirus infections,
Luis Martínez-Sobrido +1 more
doaj +1 more source
Zoonotic aspects of arenavirus infections [PDF]
Veterinary Microbiology, 2010 To date, the International Committee for Taxonomy of Viruses recognizes that the family Arenaviridae contains a unique genus Arenavirus that includes 22 viral species. There are nine additional arenaviruses that either have been discovered recently, or which taxonomic status remains pending.
Charrel, R.N., de Lamballerie, X.
openaire +3 more sources