Results 11 to 20 of about 8,755 (175)
Microorganisms, 2021 Lassa fever causes an approximate 5000 to 10,000 deaths annually in West Africa and cases have been imported into Europe and the Americas, challenging public health. Although Lassa virus was first described over 5 decades ago in 1969, no treatments or vaccines have been approved to treat or prevent infection.
Frederick Hansen +3 more
openaire +3 more sources
Characterization of Lassa Virus Cell Entry and Neutralization with Lassa Virus Pseudoparticles [PDF]
Journal of Virology, 2009 ABSTRACT The cell entry and humoral immune response of the human pathogen Lassa virus (LV), a biosafety level 4 (BSL4) Old World arenavirus, are not well characterized. LV pseudoparticles (LVpp) are a surrogate model system that has been used to decipher factors and routes involved in LV cell entry under BSL2 conditions.
François-Loïc, Cosset +8 more
openaire +4 more sources
New Hosts of The Lassa Virus [PDF]
Scientific Reports, 2016 Abstract Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis , has been assumed to be the sole host of LASV.
Olayemi, Ayodeji +19 more
openaire +3 more sources
JMIR Research Protocols, 2021 BackgroundIn 2018, the total number of Lassa fever cases in Nigeria was significantly higher than that observed in previous years. Hence, studies had attempted to determine the underlying cause. However, reports using phylogenetic methods to analyze this
Kolawole, Daniel +2 more
doaj +1 more source
Replicon System for Lassa Virus [PDF]
Journal of Virology, 2004 ABSTRACT Lassa virus is endemic to West Africa and causes hemorrhagic fever in humans. To facilitate the functional analysis of this virus, a replicon system was developed based on Lassa virus strain AV. Genomic and antigenomic minigenomes (MG) were constructed consisting of the intergenic region of S RNA and a reporter gene (
Meike, Hass +4 more
openaire +2 more sources
Viruses, 2012 Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for ...
David H. Walker, Nadezhda E. Yun
doaj +1 more source
Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Lassa fever is a viral hemorrhagic fever endemic in West Africa. However, none of the hospitals in the endemic areas of Nigeria has the capacity to perform Lassa virus diagnostics.
Danny A Asogun +29 more
doaj +1 more source
WikiJournal of Medicine, 2019 Lassa fever is a viral hemorrhagic fever caused by Lassa virus (Lassa mammarenavirus), a negative-sense single-stranded RNA virus of the Arenaviridae family. In most cases Lassa virus infection is asymptomatic (presenting no symptom). When symptomatic it
Abdulmutalab Musa
doaj +1 more source
Development of a new vaccine for the prevention of Lassa fever.
PLoS Medicine, 2005 BACKGROUND: Recent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health challenge of emerging viruses.
Thomas W Geisbert +15 more
doaj +2 more sources
Use of Favipiravir to Treat Lassa Virus Infection in Macaques
Emerging Infectious Diseases, 2018 Lassa virus, the cause of Lassa fever in humans, is endemic to West Africa. Treatment of Lassa fever is primarily supportive, although ribavirin has shown limited efficacy if administered early during infection.
Kyle Rosenke +12 more
doaj +1 more source