Results 41 to 50 of about 10,303 (224)

Immunogenesis in Lassa fever and prospects for vaccine development

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Analysis of literature data on the structure of the Lassa virus genome and its strain diversity has shown that the molecular heterogeneity of strains is essential in the design of vaccines and evaluation of their efficacy, which is determined by the ...
Vladimir A. Markin
doaj   +1 more source

Sexual and reproductive health and rights in anticipatory action for disasters

Disasters, Volume 50, Issue 3, July 2026.
Abstract An examination of the incorporation of sexual and reproductive health and rights (SRHR) in anticipatory action (AA) reveals the latter's potential to strengthen disaster response by addressing pre‐existing inequalities and marginalised needs.
Ellie Edmond Shimmin, Emmanuel Raju
wiley   +1 more source

Addressing Climate Driven Vector‐Borne Disease in West Africa

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Vector‐borne diseases (VBDs) pose a significant public health threat in West Africa, contributing to substantial morbidity and mortality, particularly among vulnerable populations. This region is highly susceptible to the effects of climate change due to its geographical location, dependence on rain‐fed agriculture, and fragile ...
Majani Edward, Oladipupo Iyanu Roseline, Emmanuel Victor, Oladeji Yinmi Gabriel   +3 more
wiley   +1 more source

Immune Responses and Lassa Virus Infection [PDF]

Viruses, 2012
Lassa fever is a hemorrhagic fever endemic to West Africa and caused by Lassa virus, an Old World arenavirus. It may be fatal, but most patients recover from acute disease and some experience asymptomatic infection. The immune mechanisms associated with these different outcomes have not yet been fully elucidated, but considerable progress has recently ...
Russier, Marion, Pannetier, Delphine, Baize, Sylvain   +2 more
openaire   +4 more sources

Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria. [PDF]

Emerg Microbes Infect
Identification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. To better characterize potential animal hosts of Lassa virus (LASV), we assessed domestic and non-domestic animals from ...
Happi AN, Ogunsanya OA, Ayinla AO, Sijuwola AE, Saibu FM, Akano K, Nwofoke C, Elias OT, Achonduh-Atijegbe O, Daodu RO, Adedokun OA, Adeyemo A, Ogundana KE, Lawal OZ, Parker E, Nosamiefan I, Okolie J, Parker ZF, McCauley MD, Eller LA, Lombardi K, Tiamiyu AB, Iroezindu M, Akinwale E, Njatou TLFA, Mebrahtu T, Broach E, Zuppe A, Prins P, Lay J, Amare M, Modjarrad K, Collins ND, Vasan S, Tucker C, Daye S, Happi CT.   +36 more
europepmc   +4 more sources

Comparison of Proteomic Analysis of Cerebrospinal Fluid From Neurological Patients With and Without Amyotrophic Lateral Sclerosis

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness in both bulbar and extremity muscles, leading to a diverse clinical phenotype with motor and non‐motor symptoms. Cerebrospinal fluid (CSF) from sporadic ALS patients were analysed for proteomics content and revealed altered inflammatory and ...
Eleonora Sabetta, Karin Rallmann, Pille Taba, Abigail L. Pfaff, Bal Hari Poudel, Davide Ferrari, Massimo Locatelli, Sulev Kõks, Jonas Bergquist   +8 more
wiley   +1 more source

DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs

Human Vaccines & Immunotherapeutics, 2017
We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models.
Kathleen A. Cashman, Eric R. Wilkinson, Suzanne E. Wollen, Joshua D. Shamblin, Justine M. Zelko, Jeremy J. Bearss, Xiankun Zeng, Kate E. Broderick, Connie S. Schmaljohn   +8 more
doaj   +1 more source

Lassa antiviral LHF-535 protects guinea pigs from lethal challenge

Scientific Reports, 2022
LHF-535 is a small molecule antiviral currently in development for the treatment of Lassa fever, a zoonotic disease endemic in West Africa that generates significant morbidity and mortality.
Kathleen A. Cashman, Eric R. Wilkinson, Jeffrey Posakony, Ikenna G. Madu, Eric J. Tarcha, Kurt H. Lustig, Marcus J. Korth, Kristin M. Bedard, Sean M. Amberg   +8 more
doaj   +1 more source

Pathogens that Cause Illness Clinically Indistinguishable from Lassa Fever, Nigeria, 2018

Emerging Infectious Diseases, 2022
During the 2018 Lassa fever outbreak in Nigeria, samples from patients with suspected Lassa fever but negative Lassa virus PCR results were processed through custom gene expression array cards and metagenomic sequencing.
Jonathan W. Ashcroft, Adebola Olayinka, Nnaemeka Ndodo, Kuiama Lewandowski, Martin D. Curran, Chioma Dan Nwafor, Kingsley Madubuike, Helen Bagnall, Abdulmajid S. Musa, Adama Ahmad, Afolabi Akinpelu, Adesola Adeleye, Chukwuji Martin, Adejoke Akano, Michael Onoja, Akanimo Iniobong, Winifred Ukponu, Chinedu Arinze, Else Ilori, Nwando Mba, Benedict Gannon, Anthony Ahumibe, Chikwe Ihekweazu   +22 more
doaj   +1 more source

Spreading Speed for a Vector‐Borne Disease System on Non‐Coincident Straight Infinite Cylinders

Studies in Applied Mathematics, Volume 156, Issue 6, June 2026.
ABSTRACT Vector‐borne diseases remain an increasing global public health concern. In this work, we investigate the spreading speed of vector‐borne disease via a four‐component reaction–diffusion system posed on non‐coincident straight infinite cylinders, which stands for an unconventional spatial configuration.
Arnaud Ducrot, Hongliang Li, David Manceau   +2 more
wiley   +1 more source