Results 31 to 40 of about 811,522 (158)

Lassa Virus Infection of Primary Human Airway Epithelial Cells

Viruses
Lassa mammarenavirus (LASV), a member of the family Arenaviridae, is a highly pathogenic virus capable of causing severe systemic infections in humans.
Helena Müller-Kräuter, Sarah Katharina Fehling, Lucie Sauerhering, Birthe Ehlert, Janine Koepke, Juliane Schilling, Mikhail Matrosovich, Andrea Maisner, Thomas Strecker   +8 more
doaj   +1 more source

Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses

mSphere, 2018
Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological
Fatima Amanat, James Duehr, Lisa Oestereich, Kathryn M. Hastie, Erica Ollmann Saphire, Florian Krammer   +5 more
doaj   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

The Adaptive Immune Response against Bunyavirales

Viruses
The Bunyavirales order includes at least fourteen families with diverse but related viruses, which are transmitted to vertebrate hosts by arthropod or rodent vectors.
Reem Alatrash, Bobby Brooke Herrera
doaj   +1 more source

Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization

mBio, 2014
The rodent arenavirus glycoprotein complex encodes a stable signal peptide (SSP) that is an essential structural component of mature virions. The SSP, GP1, and GP2 subunits of the trimeric glycoprotein complex noncovalently interact to stud the surface ...
Lydia H. Bederka, Cyrille J. Bonhomme, Emily L. Ling, Michael J. Buchmeier   +3 more
doaj   +1 more source

Surveillance of Zoonotic Pathogens in Small Mammals Across Forests With Different Levels of Anthropization in Eastern France

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The emergence of infectious diseases associated with land‐use changes is well‐documented. However, the presence and dynamics of zoonotic pathogens in small mammals within European forests, whether from rural development or urban greening, remain underexplored.
Marie Bouilloud, Maxime Galan, Anaïs Bordes, Caroline Tatard, Philippe Gauthier, Julien Pradel, Guillaume Castel, Hussein Alburkat, Lara Dutra, Tarja Sironen, Clémence Galon, Sara Moutailler, Zorée Djelouadji, Benjamin Roche, Nathalie Charbonnel, Javier Millán   +15 more
wiley   +1 more source

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Hai Wang, Yafei Meng, Xiaoyuan Chen, Xinyuan Cui, Qian Zuo, Na Han, Xianghui Liang, Xuejuan Shen, Caiwu Li, Desheng Li, Fumin Wang, Liangping He, Rujian Chen, Xingbang Lu, Wenjie You, Aiping Wu, Rui‐Ai Chen, Wu Chen, Chan Ding, Yongyi Shen   +19 more
wiley   +1 more source

The dynamics of natural Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Natural immunity to Plasmodium falciparum has been widely studied, but its effects on parasite dynamics are poorly understood. Acquisition and clearance rates of untreated infections are key elements of the dynamics of malaria, but estimating
Ingrid Felger (92160), Beck, Hans-Peter, Sama, W., Beck, H. P., Tiaden, A., Hans-Peter Beck, Bretscher, M., Nicole Falk (134915), Owusu-Agyei, Seth, Beck Hans-Peter, Felger Ingrid, Felger, Ingrid, Sama, Wilson, Sama Wilson, Maire, Martin, Tiaden, André, Ingrid Felger, Falk, Nicole, Wilson Sama (134920), Thomas A. Smith (95630), Wilson Sama, Bretscher, Michael T, André Tiaden, Seth Owusu-Agyei (80063), Tiaden André, Bretscher Michael T., Owusu-Agyei, S., Felger, I., Seth Owusu-Agyei, Owusu-Agyei Seth, Smith, T. A., Hans-Peter Beck (129757), Maire Martin, Martin Maire (134910), André Tiaden (134918), Michael T Bretscher, Michael T. Bretscher (134912), Falk Nicole, Martin Maire, Smith, Thomas A, Thomas A Smith, Falk, N., Maire, N., Nicole Falk, Smith Thomas A.   +44 more
core   +1 more source

Targeting the apical domain of the transferrin receptor: Development of a new protein scaffold for cellular delivery

Protein Science, Volume 34, Issue 12, December 2025.
Abstract Human transferrin receptor 1 (TfR) is essential for cellular iron homeostasis by internalizing the iron carrier proteins transferrin and ferritin. It is also an entry point for various pathogens, such as South American hemorrhagic fever caused by arenaviruses and the malaria parasite Plasmodium vivax, which utilize TfR to gain access to cells.
Anuthariq Alikkam Veetil, Dick J. Sjöström, Cristian Iribarren, Camilla Mohlin, Elena Ambrosetti, Sinisa Bjelic   +5 more
wiley   +1 more source

A Mutation‐Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi‐Strains: A Study Using Glycoprotein of LASV

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Lassa virus (LASV) remains a persistent threat to public health, and to combat this, various therapeutics have been developed, but their effectiveness is limited due to the virus's strain variability. Therefore, mutation‐based reverse vaccinology approaches were implemented to formulate an epitope‐based vaccine against the LASV, considering ...
Saurav Kumar Mishra, Rajesh B. Patil, Amdola Tshering Sherpa, Mohammad Borhan Uddin, Md. Harun‐Or‐Rashid, Muniruddin Ahmed, Turki M. Dawoud, John J. Georrge   +7 more
wiley   +1 more source