Results 51 to 60 of about 3,575 (156)

Targeting of arenavirus RNA synthesis by a carboxamide-derivatized aromatic disulfide with virucidal activity. [PDF]

open access: yes, 2013
Several arenaviruses can cause severe hemorrhagic fever (HF) in humans, representing a public health threat in endemic areas of Africa and South America.
Damonte, Elsa Beatriz   +4 more
core   +2 more sources

Targeting the apical domain of the transferrin receptor: Development of a new protein scaffold for cellular delivery

open access: yesProtein Science, Volume 34, Issue 12, December 2025.
Abstract Human transferrin receptor 1 (TfR) is essential for cellular iron homeostasis by internalizing the iron carrier proteins transferrin and ferritin. It is also an entry point for various pathogens, such as South American hemorrhagic fever caused by arenaviruses and the malaria parasite Plasmodium vivax, which utilize TfR to gain access to cells.
Anuthariq Alikkam Veetil   +5 more
wiley   +1 more source

A Mutation‐Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi‐Strains: A Study Using Glycoprotein of LASV

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Lassa virus (LASV) remains a persistent threat to public health, and to combat this, various therapeutics have been developed, but their effectiveness is limited due to the virus's strain variability. Therefore, mutation‐based reverse vaccinology approaches were implemented to formulate an epitope‐based vaccine against the LASV, considering ...
Saurav Kumar Mishra   +7 more
wiley   +1 more source

The Biological Characteristics and Mouse Model of Lassa Virus From the First Imported Case in China

open access: yesMedComm, Volume 6, Issue 8, August 2025.
This is the first case of Lassa fever being introduced to China. A strain of the Lineage IV LASV was successfully isolated, and genomic and mutation analysis were conducted. Infection models were constructed using BALB/c, C57BL/6, and AG129 mice, which were successfully established.
Yanan Zhou   +25 more
wiley   +1 more source

Biological Terrorism [PDF]

open access: yes, 2008
In the aftermath of the September 11, 2001 attacks and the subsequent mail-borne anthrax attack of October 2001, it has become dear that health care providers may be called upon to respond to victims of terrorism. Biological terrorism (BT), in particular,
Centers for Disease Control and Prevention   +4 more
core   +2 more sources

Marburg Virus Disease: A Narrative Review

open access: yesHealth Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Arash Letafati   +4 more
wiley   +1 more source

[Laboratory-acquired human infection with SP H 114202 virus (Arenavirus: Arenaviridae family): clinical and laboratory aspects].

open access: yesRevista do Instituto de Medicina Tropical de Sao Paulo, 1995
Here in is described the clinical and laboratorial findings of a laboratory-acquired infection caused by the virus SP H 114202 (Arenavirus, family Arenaviridae) a recently discovered agent responsible for a viral hemorrhagic fever. The patient was sick for 13 days.
P F, Vasconcelos   +5 more
openaire   +1 more source

Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells [PDF]

open access: yes, 2000
West Nile virus (WNV) is an emerging mosquito-borne pathogen that was reported for the first time in the Western hemisphere in August 1999, when an encephalitis outbreak in New York City resulted in 62 clinical cases and 7 deaths.
Briese, Thomas   +4 more
core   +2 more sources

Opinion and report of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the assessment of the impact of fox population dynamics on public health

open access: yesFood Risk Assess Europe, Volume 3, Issue 2, April 2025.
ABSTRACT The Red Fox (Vulpes vulpes) can be hunted as a game species. It may also be listed as a “species likely to cause damage” (ESOD – the acronym in French), for public health reasons among others. Conversely, benefits linked to the presence of foxes are also put forward, such as the predation of rodents carrying zoonotic agents.
Emmanuelle Gilot‐Fromont   +97 more
wiley   +1 more source

Evaluation of a Luminex‐Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal

open access: yesTransboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Given the growing threat posed by viral hemorrhagic fevers, the development of surveillance tools is crucial to provide accurate and rapid solutions. Public health response involves risk assessment as well as effective and sustainable surveillance to ensure downstream communication and preparedness. A serological approach that offers high precision and
Safietou Sankhe   +17 more
wiley   +1 more source

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