Results 51 to 60 of about 3,640,579 (169)

A Mutation‐Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi‐Strains: A Study Using Glycoprotein of LASV

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Lassa virus (LASV) remains a persistent threat to public health, and to combat this, various therapeutics have been developed, but their effectiveness is limited due to the virus's strain variability. Therefore, mutation‐based reverse vaccinology approaches were implemented to formulate an epitope‐based vaccine against the LASV, considering ...
Saurav Kumar Mishra, Rajesh B. Patil, Amdola Tshering Sherpa, Mohammad Borhan Uddin, Md. Harun‐Or‐Rashid, Muniruddin Ahmed, Turki M. Dawoud, John J. Georrge   +7 more
wiley   +1 more source

The Biological Characteristics and Mouse Model of Lassa Virus From the First Imported Case in China

MedComm, Volume 6, Issue 8, August 2025.
This is the first case of Lassa fever being introduced to China. A strain of the Lineage IV LASV was successfully isolated, and genomic and mutation analysis were conducted. Infection models were constructed using BALB/c, C57BL/6, and AG129 mice, which were successfully established.
Yanan Zhou, Junbin Wang, Ranran Cao, Yun Yang, Yuliang Feng, Cong Tang, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang, Jiandong Shi, Kaiyun Ding, Longhai Yuan, Qing Dai, Xingping Zhao, Haiyan Li, Mengli Yang, Fangyu Luo, Fanli Zhu, Yong Zhang, Daoju Wu, Xiaorong Yang, Shuaiyao Lu, Qiangming Sun, Li Zhang, Youchun Wang   +25 more
wiley   +1 more source

Marburg Virus Disease: A Narrative Review

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Arash Letafati, Somayeh Sadat Hosseini Fakhr, Ali Qaraee Najafabadi, Negin Karami, Hassan Karami   +4 more
wiley   +1 more source

[Laboratory-acquired human infection with SP H 114202 virus (Arenavirus: Arenaviridae family): clinical and laboratory aspects].

Revista do Instituto de Medicina Tropical de Sao Paulo, 1995
Here in is described the clinical and laboratorial findings of a laboratory-acquired infection caused by the virus SP H 114202 (Arenavirus, family Arenaviridae) a recently discovered agent responsible for a viral hemorrhagic fever. The patient was sick for 13 days.
P F, Vasconcelos, A P, Travassos da Rosa, S G, Rodrigues, R, Tesh, J F, Travassos da Rosa, E S, Travassos da Rosa   +5 more
openaire   +1 more source

Opinion and report of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the assessment of the impact of fox population dynamics on public health

Food Risk Assess Europe, Volume 3, Issue 2, April 2025.
ABSTRACT The Red Fox (Vulpes vulpes) can be hunted as a game species. It may also be listed as a “species likely to cause damage” (ESOD – the acronym in French), for public health reasons among others. Conversely, benefits linked to the presence of foxes are also put forward, such as the predation of rodents carrying zoonotic agents.
Emmanuelle Gilot‐Fromont, Isabelle Villena, Elsa Bonnaud, Claude Fischer, Etienne Giraud, Annick Linden, François Meurens, Carine Paraud, Francis Raoul, Céline Richomme, Sandrine Ruette, Michel Trommetter, Isabelle Vallée, Gilles Meyer, Xavier Bailly, Catherine Belloc, Stéphane Bertagnoli, Alain Boissy, Séverine Boullier, Henri‐Jean Boulouis, Eric Cardinale, Aurélie Courcoul, Alice De Boyer Des Roches, Barbara Dufour, Veasna Duong, Lionel Grisot, Claire Guinat, Nadia Haddad, Elsa Jourdain, Hervé Juin, Sophie Le Bouquin‐Le Neveu, Caroline Le Maréchal, Sophie Le Poder, Yves Millemann, Pierre Mormède, Carole Peroz, Claire Ponsart, Claude Saegerman, Jean‐François Valarcher, Isabelle Vallée, Agnès Waret‐Szkuta, Natacha Woronoff‐Rehn, Laura Maxim, Louis‐Georges Soler, Bénédicte Apouey, Luc Baumstark, Céline Bonnet, Thierry Brunelle, France Caillavet, Alain Carpentier, Thomas Coutrot, Cécile Detang‐Dessendre, Serge Garcia, Julien Gauthey, Emmanuelle Lavaine, Christine Le Clainche, Marc Leandri, Youenn Loheac, Sélim Louafi, Eric Plottu, Elodie Rouviere, Maïder Saint‐Jean, Denis Salles, Léa Tardieu, Jean‐Christophe Vergnaud, Philippe Fravalo, Frédéric Auvray, Mickaël Boni, Frédéric Borges, Gilles Bornert, Frédéric Carlin, Catherine Chubilleau, Monika Coton, Georges Daube, Noémie Desriac, Florence Dubois‐Brissonnet, Michel Federighi, Michel Gautier, Michèle Gourmelon, Sandrine Guillou, Stéphane Guyot, Didier Hilaire, Nathalie Jourdan‐da Silva, Claire Le Henaff‐Le Marrec, Sandra Martin‐Latil, Jeanne‐Marie Membré, Eric Oswald, Nadia Oulahal, Pascal Piveteau, Sabine Schorr‐Galindo, Régine Talon, Isabelle Villena, Emmanuelle Robardet, Nathalie Arnich, Karine Fiore, Florence Etoré, Véronique Raimond, Catherine Collignon   +97 more
wiley   +1 more source

Evaluation of a Luminex‐Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Given the growing threat posed by viral hemorrhagic fevers, the development of surveillance tools is crucial to provide accurate and rapid solutions. Public health response involves risk assessment as well as effective and sustainable surveillance to ensure downstream communication and preparedness. A serological approach that offers high precision and
Safietou Sankhe, Maryam Diarra, Mamadou Aliou Barry, Martin Faye, Cheikh Talla, Diogop Camara, Maimouna Mbanne, Pape Mbacke Sembene, Amadou Alpha Sall, Gamou Fall, Oumar Faye, Cheikh Loucoubar, Ousmane Faye, Ines Vigan-Womas, Keersten Michelle Ricks, Jessica Radzio-Basu, Moussa Moise Diagne, Leyi Wang   +17 more
wiley   +1 more source

Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential

Zoological Research, 2018
Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors (Ifnar–/–) are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to
G. Wong, X. Qiu
semanticscholar   +1 more source

Challenges Associated With Re‐Emergence of Lassa Fever in Nigeria: An Exploratory Study of Epidemiology, Phylogenomics, and Recommendations Toward Its Eradication

Health Science Reports, Volume 7, Issue 12, December 2024.
ABSTRACT Background Lassa fever (LF) is a viral hemorrhagic illness endemic in Nigeria and other West African countries. In recent years, the number of reported cases of LF in Nigeria has increased. In this study, we discussed the epidemiology of LF, the phylogenomics of the LF virus, issues associated with the increased cases of LF, and ...
Ridwan Olamilekan Adesola, Ibrahim Idris, Adetolase Azizat Bakre, Joseph Fosu Arthur, Joanna Nicole D'Souza   +4 more
wiley   +1 more source

Lassa Virus Nucleoprotein Mutants Generated by Reverse Genetics Induce a Robust Type I Interferon Response in Human Dendritic Cells and Macrophages

, 2011
International audienceLassa virus (LASV; Arenaviridae) is responsible for severe hemorrhagic fevers in Africa. LASV nucleoprotein (NP) plays important roles in regulating viral transcription and replication and in inhibiting type I interferon (IFN ...
Carnec, Xavier, Sylvain Baize, Michèle Bouloy, Stéphanie Reynard, Caro, Valerie, Diancourt, Laure, Reynard, Stéphanie, Bouloy, Michèle, Baize, Sylvain, Laure Diancourt, Noel Tordo, Tordo, Noel, Xavier Carnec, Valérie Caro   +13 more
core   +1 more source

Investigation of Viral, Bacterial and Parasitic Zoonotic Diseases in Rodents in Turkey

Veterinary Medicine and Science, Volume 10, Issue 6, November 2024.
Rodents are reservoir hosts for zoonotic pathogens. In this study, the presence of viral lymphocytic choriomeningitis and hantavirus infections, bacterial tularaemia and leptospirosis, and parasitic leishmaniasis and toxoplasmosis were investigated in 498 rodents collected in Erzurum province, Turkey.
Mehmet Ozkan Timurkan, Esin Guven, Seyda Cengiz, Hakan Aydın, Ridvan Kirman, Hamza Avcioglu   +5 more
wiley   +1 more source