Uncoupling GP1 and GP2 expression in the Lassa virus glycoprotein complex: implications for GP1 ectodomain shedding [PDF]
Background Sera from convalescent Lassa fever patients often contains antibodies to Lassa virus (LASV) glycoprotein 1 (GP1), and glycoprotein 2 (GP2); Immunization of non-human primates with viral vectors expressing the arenaviral glycoprotein complex ...
Illick Kerry A +7 more
core +2 more sources
Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression [PDF]
Junin virus (JUNV), a highly pathogenic New World arenavirus, is the causative agent of Argentine hemorrhagic fever (AHF). The live-attenuated Candid #1 (Can) strain currently serves as a vaccine for at-risk populations. We have previously shown that the
Alexey V. Seregin +7 more
core +1 more source
Molecular Diagnostics for Lassa Fever at Irrua Specialist Teaching Hospital, Nigeria: Lessons Learnt from Two Years of Laboratory Operation [PDF]
Background: Lassa fever is a viral hemorrhagic fever endemic in West Africa. However, none of the hospitals in the endemic areas of Nigeria has the capacity to perform Lassa virus diagnostics.
Adomeh, Donatus I. +29 more
core +1 more source
Macaque models of human infectious disease. [PDF]
Macaques have served as models for more than 70 human infectious diseases of diverse etiologies, including a multitude of agents-bacteria, viruses, fungi, parasites, prions.
Abe +330 more
core +1 more source
Viral hemorrhagic fevers: Advancing the level of treatment [PDF]
The management of viral hemorrhagic fevers (VHFs) has mainly focused on strict infection control measures, while standard clinical interventions that are provided to patients with other life-threatening conditions are rarely offered to patients with VHFs.
Ippolito G. +6 more
core +1 more source
Boid inclusion body disease : the enigma unraveled? [PDF]
Boid inclusion body disease is a worldwide occurring disease in boas and pythons. The identity of the etiological agent of the disease remained elusive for several decades.
Hellebuyck, Tom, Simard, Jules
core
La schizophrénie touche aussi les enfants et les adolescents : une des modalités de leur prise en charge est assurée par le CTJA [Centre thérapeutique de jour pour adolescents] [PDF]
1% des schizophrénies se déclenchent avant l'âge de 10 ans. 20%, une sur cinq, commencent avant l'âge de 18 ans. Et dans 40% des cas de schizophrénie avérée, les premiers signes étaient apparus avant 18 ans.
Dunand, Fabien, Holzer, Laurent
core
Pseudotyped Lentiviral Vectors: One Vector, Many Guises [PDF]
Viruses have evolved specialized molecular mechanisms to transfer their genome efficiently into host cells. Viruses can be repurposed into viral vectors to achieve controlled gene transfer to desired cells.
Joglekar, Alok V., Sandoval, Salemiz
core
Review of Mammarenavirus Biology and Replication [PDF]
The family Arenaviridae is divided into three genera: Mammarenavirus, Reptarenavirus, and Hartmanivirus. The Mammarenaviruses contain viruses responsible for causing human hemorrhagic fever diseases including New World viruses Junin, Machupo, Guanarito ...
Hallam, Steven J. +3 more
core
Let’s not make the same mistake again: A political economy analysis of Sierra Leone’s Cholera and Ebola epidemic responses [PDF]
The Ebola epidemic in West Africa resulted in calls for universal health coverage and revision of global health governance for emergency response. This political economy analysis identifies structural reasons why Sierra Leone and the international health
McCollum, Rosalind, Taegtmeyer, Miriam
core

