Results 11 to 20 of about 3,575 (156)

Local Maintenance and Genomic Diversity of Lymphocytic Choriomeningitis Virus in Natural Populations of House Mice in the Czech Republic Over a 24-Year Period. [PDF]

Zoonoses Public Health
ABSTRACT Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent‐borne zoonotic virus primarily infecting house mice. The virus can be highly pathogenic, particularly in immunocompromised individuals and in congenital infections. LCMV is distributed worldwide but shows local clustering, probably due to the highly structured populations of its ...
Jezkova I, Fornůsková A, Ďureje Ľ, Macholán M, Piálek J, de Bellocq JG.   +5 more
europepmc   +2 more sources

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High-Throughput Sequencing Data Mining. [PDF]

Adv Sci (Weinh)
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Wang H, Meng Y, Chen X, Cui X, Zuo Q, Han N, Liang X, Shen X, Li C, Li D, Wang F, He L, Chen R, Lu X, You W, Wu A, Chen RA, Chen W, Ding C, Shen Y.   +19 more
europepmc   +2 more sources

Strategic Preparedness of Broad-Spectrum Antivirals for Rapid Response Towards Next Pandemics. [PDF]

Small Sci
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
N SR, Jin GW, Choy JH.
europepmc   +2 more sources

Luminescent reporter cells enable the identification of broad‐spectrum antivirals against emerging viruses

Journal of Medical Virology, Volume 95, Issue 11, November 2023., 2023
Abstract The emerging viruses SARS‐CoV‐2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs).
Karin Löw, Rebecca Möller, Cora Stegmann, Miriam Becker, Laura Rehburg, Helena Obernolte, Dirk Schaudien, Lisa Oestereich, Armin Braun, Stefan Kunz, Gisa Gerold   +10 more
wiley   +1 more source

Re‐emergence of Lassa fever in Nigeria: A new challenge for public health authorities

Health Science Reports, Volume 6, Issue 10, October 2023., 2023
Abstract The Lassa virus is an RNA virus belonging to the Arenaviridae family. It is responsible for Lassa fever, an acute viral zoonosis of the severe hemorrhagic fever type with manifestations of fever, muscle pain, sore throat, nausea, vomiting, and chest and abdominal pain. Lassa fever is endemic in West Africa, where the first case was reported in
Aroma Naeem, Shafaq Zahid, Muhammad Hassan Hafeez, Arifa Bibi, Shehroze Tabassum, Aymar Akilimali   +5 more
wiley   +1 more source

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

Viruses, 2020
Mammarenaviruses cause chronic infections in rodents, which are their predominant natural hosts. Human infection with some of these viruses causes high-consequence disease, posing significant issues in public health.
Yu-Jin Kim, Beatrice Cubitt, Yingyun Cai, Jens H. Kuhn, Daniel Vitt, Hella Kohlhof, Juan C. de la Torre   +6 more
doaj   +1 more source

Multiple infections of zoonotic pathogens in wild Brandt's voles (Lasiopodomys brandtii)

Veterinary Medicine and Science, Volume 9, Issue 5, Page 2201-2211, September 2023., 2023
Our research revealed the viral and bacterial diversity in wild Brandt's voles. The characterization and distinctive lineage of some rodent‐specific viruses (Cytomegalovirus, PestVs and Lentiviruses) and rodent‐borne bacteria (Leptospira interrogans and Vibrio cholerae) indicates that wild Brandt's voles may harbor a diversity of viruses and bacteria ...
Yongman Guo, Zhengrun Li, Shike Dong, Xiaoyan Si, Na Ta, Hanwei Liang, Lei Xu   +6 more
wiley   +1 more source

Imported Lassa Fever, Pennsylvania, USA, 2010

Emerging Infectious Diseases, 2010
We report a case of Lassa fever in a US traveler who visited rural Liberia, became ill while in country, sought medical care upon return to the United States, and subsequently had his illness laboratory confirmed.
Valerianna Amorosa, Adam MacNeil, Ryan McConnell, Ami Patel, Katherine E. Dillon, Keith Hamilton, Bobbie Rae Erickson, Shelley Campbell, Barbara Knust, Deborah L. Cannon, David M. Miller, Craig Manning, Pierre E. Rollin, Stuart T. Nichol   +13 more
doaj   +1 more source

Detection of Latino virus (Arenaviridae: Mammarenavirus) naturally infecting Calomys callidus

Acta Tropica, 2018
Mammarenavirus species are associated with a specific rodent host species, although an increasing number of virus has been associated to more than one host, suggesting that co-evolution is less robust than initially thought. There are few eco-epidemiological studies of South America mammarenaviruses in non-endemic areas of Arenavirus Hemorrhagic Fever,
Jorlan, Fernandes, Renata Carvalho, de Oliveira, Alexandro, Guterres, Débora Ferreira, Barreto-Vieira, Ana Claudia Pereira, Terças, Bernardo Rodrigues, Teixeira, Marcos Alexandre Nunes, da Silva, Gabriela Cardoso, Caldas, Janice Mery Chicarino, de Oliveira Coelho, Ortrud Monika, Barth, Paulo Sergio, D'Andrea, Cibele Rodrigues, Bonvicino, Elba Regina Sampaio, de Lemos   +12 more
openaire   +2 more sources

Differential Disease Susceptibilities in Experimentally Reptarenavirus-Infected Boa Constrictors and Ball Pythons. [PDF]

, 2017
Inclusion body disease (IBD) is an infectious disease originally described in captive snakes. It has traditionally been diagnosed by the presence of large eosinophilic cytoplasmic inclusions and is associated with neurological, gastrointestinal, and ...
Boback, Scott M, DeRisi, Joseph L, Drazenovich, Tracy, Garcia, Valentina E, Hawkins, Michelle G, Hoon-Hanks, Laura L, Keel, M Kevin, Layton, Marylee L, Sanchez-Migallon Guzman, David, Stenglein, Mark D   +9 more
core   +1 more source