Results 11 to 20 of about 2,533 (119)

Local Maintenance and Genomic Diversity of Lymphocytic Choriomeningitis Virus in Natural Populations of House Mice in the Czech Republic Over a 24-Year Period. [PDF]

Zoonoses Public Health
ABSTRACT Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent‐borne zoonotic virus primarily infecting house mice. The virus can be highly pathogenic, particularly in immunocompromised individuals and in congenital infections. LCMV is distributed worldwide but shows local clustering, probably due to the highly structured populations of its ...
Jezkova I, Fornůsková A, Ďureje Ľ, Macholán M, Piálek J, de Bellocq JG.   +5 more
europepmc   +2 more sources

Missed Opportunities for Timely Diagnosis and Effective Therapeutic Management of Prolonged Fever: A Case Study of Confirmed Lassa Fever in N’Zérékoré, Guinea, 2022 [PDF]

Case Reports in Infectious Diseases
Background Lassa fever is a potentially fatal viral hemorrhagic disease caused by a ribonucleic acid (RNA) virus of the Arenaviridae family, endemic in West Africa. It is highly virulent and contagious in several countries, with a nonspecific clinical presentation that poses a major public health challenge.
Cherif I, Essis E, Diallo M, Konan L, Kamano A, Kpebo D, Dia S, Baldé M, Condé S, Cherif F, Millimono M, Kouyaté F, Loua A, Condé L.   +13 more
europepmc   +2 more sources

Luminescent reporter cells enable the identification of broad‐spectrum antivirals against emerging viruses

Journal of Medical Virology, Volume 95, Issue 11, November 2023., 2023
Abstract The emerging viruses SARS‐CoV‐2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs).
Karin Löw, Rebecca Möller, Cora Stegmann, Miriam Becker, Laura Rehburg, Helena Obernolte, Dirk Schaudien, Lisa Oestereich, Armin Braun, Stefan Kunz, Gisa Gerold   +10 more
wiley   +1 more source

Re‐emergence of Lassa fever in Nigeria: A new challenge for public health authorities

Health Science Reports, Volume 6, Issue 10, October 2023., 2023
Abstract The Lassa virus is an RNA virus belonging to the Arenaviridae family. It is responsible for Lassa fever, an acute viral zoonosis of the severe hemorrhagic fever type with manifestations of fever, muscle pain, sore throat, nausea, vomiting, and chest and abdominal pain. Lassa fever is endemic in West Africa, where the first case was reported in
Aroma Naeem, Shafaq Zahid, Muhammad Hassan Hafeez, Arifa Bibi, Shehroze Tabassum, Aymar Akilimali   +5 more
wiley   +1 more source

Multiple infections of zoonotic pathogens in wild Brandt's voles (Lasiopodomys brandtii)

Veterinary Medicine and Science, Volume 9, Issue 5, Page 2201-2211, September 2023., 2023
Our research revealed the viral and bacterial diversity in wild Brandt's voles. The characterization and distinctive lineage of some rodent‐specific viruses (Cytomegalovirus, PestVs and Lentiviruses) and rodent‐borne bacteria (Leptospira interrogans and Vibrio cholerae) indicates that wild Brandt's voles may harbor a diversity of viruses and bacteria ...
Yongman Guo, Zhengrun Li, Shike Dong, Xiaoyan Si, Na Ta, Hanwei Liang, Lei Xu   +6 more
wiley   +1 more source

Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. [PDF]

PLoS Neglected Tropical Diseases, 2011
Lassa and Junín viruses are the most prominent members of the Arenaviridae family of viruses that cause viral hemorrhagic fever syndromes Lassa fever and Argentine hemorrhagic fever, respectively.
Michelle Mendenhall, Andrew Russell, Donald F Smee, Jeffery O Hall, Ramona Skirpstunas, Yousuke Furuta, Brian B Gowen   +6 more
doaj   +1 more source

Lassa fever vaccine candidates: A scoping review of vaccine clinical trials

Tropical Medicine &International Health, Volume 28, Issue 6, Page 420-431, June 2023., 2023
Abstract Objective Lassa fever (LF) is caused by a viral pathogen with pandemic potential. LF vaccines have the potential to prevent significant disease in individuals at risk of infection, but no such vaccine has been licensed or authorised for use thus far.
Giorgia Sulis, Alexandra Peebles, Nicole E. Basta   +2 more
wiley   +1 more source

Lassa fever. Part 1. Etiology, epidemiology and clinical manifestations

Инфекция и иммунитет, 2022
Lassa fever is a natural focal disease dangerous for humans. In the larger part of sub-Saharan West Africa 37.7 million people in 14 countries live in areas where living conditions are suitable for zoonotic transmission of the virus from secretions of ...
Elena I. Kazachinskaia, V. S. Aripov, A. V. Ivanova, A. M. Shestopalov   +3 more
doaj   +1 more source

Detection of Latino virus (Arenaviridae: Mammarenavirus) naturally infecting Calomys callidus

Acta Tropica, 2018
Mammarenavirus species are associated with a specific rodent host species, although an increasing number of virus has been associated to more than one host, suggesting that co-evolution is less robust than initially thought. There are few eco-epidemiological studies of South America mammarenaviruses in non-endemic areas of Arenavirus Hemorrhagic Fever,
Jorlan, Fernandes, Renata Carvalho, de Oliveira, Alexandro, Guterres, Débora Ferreira, Barreto-Vieira, Ana Claudia Pereira, Terças, Bernardo Rodrigues, Teixeira, Marcos Alexandre Nunes, da Silva, Gabriela Cardoso, Caldas, Janice Mery Chicarino, de Oliveira Coelho, Ortrud Monika, Barth, Paulo Sergio, D'Andrea, Cibele Rodrigues, Bonvicino, Elba Regina Sampaio, de Lemos   +12 more
openaire   +2 more sources

Biodistribution and toxicology evaluation of a recombinant measles Schwarz‐based Lassa vaccine in cynomolgus macaques

Journal of Applied Toxicology, Volume 43, Issue 5, Page 719-733, May 2023., 2023
Abstract MV‐LASV is an investigational measles Schwarz‐based vaccine for the prevention of Lassa fever. A repeated‐dose toxicity study in cynomolgus macaques was performed to assess the biodistribution and local and systemic toxicological effects. Monkeys received three immunizations of MV‐LASV or saline intramuscularly with a 2‐week interval.
Sabrina Schrauf, Yvonne Tomberger, Sham Nambulli, W. Paul Duprex, Roland Tschismarov, Erich Tauber, Katrin Ramsauer   +6 more
wiley   +1 more source