Results 21 to 30 of about 194,872 (254)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Relaciones de la Sociedad Argentina de Antropología, 2023 Investigaciones históricas, etnográficas y arqueológicas dan cuenta de una intensa interacción entre los valles Calchaquíes y la Puna, en el noroeste de Argentina, al menos desde el primer milenio hasta mediados del siglo XX.
María Cecilia Castellanos +1 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Revista Brasileira de História & Ciências Sociais, 2015 Os comandantes de Guardas Nacionais tiveram um papel importante na construção do Estado argentino a partir de meados do século XIX. Isso se deveu, entre outras coisas, à grande capacidade para neutralizar os ataques indígenas, ou pelo menos, reduzir as ...
Leonardo Canciani
doaj +2 more sources
Evaluating Energy Absorption Performance of Filled Lattice Structures
Advanced Engineering Materials, EarlyView.Maximum stress must be considered to robustly evaluate energy absorber designs. This approach was applied to compare all types of absorbers in a single Ashby diagram and determine the utility of filling lattice voids with a second material. High‐performance fillers can improve the performance of lattices that are limited by buckling or catastrophic ...
Christian Bonney +2 more
wiley +1 more source
MATEC Web of Conferences, 2017 Recently, the depletion of petroleum resources and the impact of exhaust emission caused by combustion towards environmental has been forced to all researchers to come out with an alternative ways to prevent this situation become worse.
Kamaruddin M. Hazeem +4 more
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Multimodal Data‐Driven Microstructure Characterization
Advanced Engineering Materials, EarlyView.A self‐consistent autonomous workflow for EBSP‐based microstructure segmentation by integrating PCA, GMM clustering, and cNMF with information‐theoretic parameter selection, requiring no user input. An optimal ROI size related to characteristic grain size is identified.
Qi Zhang +4 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.We develop a data‐driven method to derive the mathematical expressions of the Flory–Huggins interaction parameter χ for the swelling behavior of temperature–responsive hydrogels. Starting from initial assumptions of χ, our workflow combines Bayesian optimization, Flory–Rehner theory, and symbolic regression to generate candidate χ expressions.
Yawen Wang +2 more
wiley +1 more source
Barreras y facilitadores en las trayectorias de mujeres con Cáncer de Mama usuarias de Hospitales Públicos [PDF]
Revista Argentina de Salud Pública, 2018 El cáncer de mama (CM) es el segundo más común en el mundo y el más frecuente entre las mujeres. La incidencia varía entre regiones. Además, el CM es la quinta causa de muerte por cáncer a nivel mundial, la más frecuente en las regiones menos ...
Silvina, Ramos +10 more
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