Results 21 to 30 of about 246,254 (250)

Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2′)-Orn-NH₂] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2′)-Arg-NH₂]

, 2023
Discovery of pan-antagonist ligands for the melanocortin receptors will help identify the physiological activities controlled by these receptors. The previously reported MC3R/MC4R antagonist Ac-DPhe(pI)-Arg-Nal(2′)-Arg-NH2 was identified herein, for the ...
Sarah S. Mathre (16317495), Sarah S. Mathre, Katie T. Freeman, Carrie Haskell-Luevano, Mark D. Ericson (3644095), Kelsey Holdaway, Kristen John, Linh T. Tran, Kelsey Holdaway (16317498), Mark D. Ericson, Jacob L. Bouchard, Katie T. Freeman (3644092), Linh T. Tran (16317492), Mary M. Lunzer, Kristen John (381275), Mary M. Lunzer (1330443), Jacob L. Bouchard (11938542), Carrie Haskell-Luevano (1322436)   +17 more
core   +2 more sources

The Prevalence of Systemic Venous Congestion Post Kidney Transplant Detected by Point of Care Ultrasound (POCUS)

POCUS Journal
Systemic venous congestion is a known cause of acute kidney injury (AKI), but its presence in kidney transplant patients has not been previously described in the literature.
Santiago Beltramino, Agustín Manchado Bruno, Damián Fernández, Javier Walther, Gustavo Werber   +4 more
doaj   +1 more source

Emissions Characteristics of Small Diesel Engine Fuelled by Waste Cooking Oil

MATEC Web of Conferences, 2014
Biodiesel is an alternative, decomposable and biological-processed fuel that has similar characteristics with mineral diesel which can be used directly into diesel engines. However, biodiesel has oxygenated, more density and viscosity compared to mineral
Khalid Amir, Anuar M.D., Ishak Yusri, Manshoor B., Sapit Azwan, Leman Mutalib, Zaman Izzuddin   +6 more
doaj   +1 more source

Seasonal variations in antibiotic resistance gene transport in the Almendares River, Havana, Cuba [PDF]

, 2012
Numerous studies have quantified antibiotic resistance genes (ARG) in rivers and streams around the world, and significant relationships have been shown that relate different pollutant outputs and increased local ARG levels.
Olivares-Rieumont, Susana, Knapp, Charles, Lima, Lazaro, Emma eBowen, David eWerner, Lazaro Lima, David W. Graham, Werner, David, Charles W. Knapp, Susana Olivares-Rieumont, Emma Bowen, Charles W Knapp, Lazaro eLima, Bowen, Emma, David Werner, Graham, David W., David W eGraham, Susana eOlivares-Rieumont   +17 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Circuitos de interacción y evidencias materiales entre las quebradas altas del valle Calchaquí y la Puna (siglos X-XVI)

Relaciones de la Sociedad Argentina de Antropología, 2023
Investigaciones históricas, etnográficas y arqueológicas dan cuenta de una intensa interacción entre los valles Calchaquíes y la Puna, en el noroeste de Argentina, al menos desde el primer milenio hasta mediados del siglo XX.
María Cecilia Castellanos, Verónica Isabel Williams   +1 more
doaj   +1 more source

Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy

, 2019
The melanocortin receptors are stimulated by agonists (α-MSH, β-MSH, γ-MSH, and ACTH) processed from the proopiomelanocortin (POMC) gene transcript and possess a common His-Phe-Arg-Trp tetrapeptide sequence critical for receptor activation. Deficiency in
Mark D. Ericson, Katie T. Freeman, Carrie Haskell-Luevano, Mark D. Ericson (3644095), Katie T. Freeman (3644092), Marshall D. Winget, Marshall D. Winget (7037072), Carrie Haskell-Luevano (1322436)   +7 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source