Results 31 to 40 of about 246,254 (250)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Predicting the performances of a CAMPRO engine retrofitted with liquefied petroleum gas (LPG) system using 1-dimensional software

MATEC Web of Conferences, 2017
Recently, the depletion of petroleum resources and the impact of exhaust emission caused by combustion towards environmental has been forced to all researchers to come out with an alternative ways to prevent this situation become worse.
Kamaruddin M. Hazeem, Osman Shahrul Azmir, Fawzi Mas, Mustaffa Norrizal, Tukiman Mohd Mustaqim   +4 more
doaj   +1 more source

Anthropomorphic Polydimethylsiloxane silicone-based phantom for Diffuse Optical Imaging

Heliyon, 2022
This work presents a method for constructing phantoms suitable for diffuse optical mammography. They are based on Polydimethylsiloxane silicones, with the characteristic of being anthropomorphic, and having similar mechanical and optical properties as a ...
M.V. Waks Serra, V. Noseda Grau, D.A. Vera, S. Jodra, H.A. García, N.A. Carbone, P.A. Pardini, J.A. Pomarico, D.I. Iriarte   +8 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Entre os enfrentamentos e as relações pacíficas. Comandantes de Guardas Nacionais e os indígenas na fronteira sul bonaerense (1852-1879).

Revista Brasileira de História & Ciências Sociais, 2015
Os comandantes de Guardas Nacionais tiveram um papel importante na construção do Estado argentino a partir de meados do século XIX. Isso se deveu, entre outras coisas, à grande capacidade para neutralizar os ataques indígenas, ou pelo menos, reduzir as ...
Leonardo Canciani
doaj   +2 more sources

Barreras y facilitadores en las trayectorias de mujeres con Cáncer de Mama usuarias de Hospitales Públicos [PDF]

Revista Argentina de Salud Pública, 2018
El cáncer de mama (CM) es el segundo más común en el mundo y el más frecuente entre las mujeres. La incidencia varía entre regiones. Además, el CM es la quinta causa de muerte por cáncer a nivel mundial, la más frecuente en las regiones menos ...
Silvina, Ramos, Cecilia, Straw, María, Viniegra, Cecilia, Almada, Marcela , Schneider, Verónica, Pesce, Luciano, Mignini, Gonzalo , Tabares, Nadia, Robles, Ivana, Romero, Victoria , Moretto   +10 more
doaj  

Forest plot of Pro/Pro+ Pro/Arg versus Arg/Arg for all studies.

, 2013
Forest plot of Pro/Pro+ Pro/Arg versus Arg/Arg for all studies.
Jun Ye (346649), Yong-Dong Wang (152342), Ying Yuan (133529), Xiao-Fen Li (481848)   +3 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Interpretable Robot Control via Structured Behavior Trees and Large Language Models

IEEE Access
As intelligent robots become more integrated into human environments, there is a growing need for intuitive and reliable Human-Robot Interaction (HRI) interfaces that are adaptable and more natural to interact with.
Ingrid Maeva Chekam, Ines Pastor-Martinez, Ali Tourani, Jose Andres Millan-Romera, Laura Ribeiro, Pedro Miguel Bastos Soares, Holger Voos, Jose Luis Sanchez-Lopez   +7 more
doaj   +1 more source