Results 181 to 190 of about 50,915 (302)

Retraction: The effects of the M2a macrophage-induced axonal regeneration of neurons by arginase 1. [PDF]

Biosci Rep
Zhang J, Li Y, Duan Z, Kang J, Chen K, Li G, Weng C, Zhang D, Zhang L, Wang J, Li B.   +10 more
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

The alternative polyadenylation factor CFIm25 orchestrates macrophage antibacterial activity against <i>Salmonella</i> through the TAB2 and TBL1XR1 regulators of MAPK and NF-κB signaling. [PDF]

Infect Immun
Barua A, Mukherjee S, Bourgeois J, Moore CL.   +3 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Immunochemotherapy with Amphotericin B and HisAK70 Vaccine for Cutaneous Leishmaniosis. [PDF]

Int J Mol Sci
Espuelas S, Palomino-Cano C, Torrado-Salmerón C, Ruiz HK, de la Torre-Iglesias PM, Torrado-Santiago S, Torrado JJ, Alunda JM, Dardonville C, Sánchez Guirales SA, Serrano DR, Carrión J.   +11 more
europepmc   +1 more source

4‐1BBL Suppresses Anti‐Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages

Immunology, Volume 179, Issue 3, Page 434-443, November 2026.
4‐1BB ligand (4‐1BBL) is known to promote sustained pro‐inflammatory responses in macrophages. This study demonstrates that 4‐1BBL acts as a negative regulator of anti‐inflammatory macrophage responses. Genetic deletion or pharmacological inhibition of 4‐1BBL significantly enhanced the phosphorylation of IL‐4R‐proximal JAK1 and STAT6, elevating the ...
Young Jun Kang
wiley   +1 more source

Crystal structure of a cold-active arginase from Glaciozyma antarctica. [PDF]

Acta Crystallogr F Struct Biol Commun
Quay DHX, Yusof NY, Jonet MA, Kamaruddin S, Md Illias R, Mahadi NM, Keep N, Firdaus-Raih M, Abu Bakar FD, Abdul Murad AM.   +9 more
europepmc   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Arginase 2 deficiency mitigates sepsis-associated acute kidney injury by alleviating lipid accumulation. [PDF]

Clin Transl Med
Xin Y, Liu Y, Zhang N, Huang P, Zhang Q, Luo Y, Wang X, Zhang X, Wu T, Liu F, Xiao Y, Shen L, Zhang W, Wang X, Meng X, Bai Y, Wang X, Zhang N, Xu Q, Meng H, Zheng X, Cheng L, Yu K, Wang C.   +23 more
europepmc   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, Volume 15, Issue 40, 27 October 2026.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source