Role of tubular epithelial arginase-II in renal inflammaging [PDF]
npj Aging and Mechanisms of Disease, 2021 The aging kidney undergoes complex changes and is vulnerable to injury and development of chronic kidney disease (CKD) with preponderance affecting more women than men.
Ji Huang +5 more
doaj +6 more sources
Role of Arginase-II in Podocyte Injury under Hypoxic Conditions [PDF]
Biomolecules, 2022 Hypoxia plays a crucial role in acute and chronic renal injury, which is attributable to renal tubular and glomerular cell damage. Some studies provide evidence that hypoxia-dependent upregulation of the mitochondrial enzyme arginase type-II (Arg-II) in ...
Zhilong Ren +6 more
doaj +5 more sources
Arginase-II Deficiency Extends Lifespan in Mice [PDF]
Frontiers in Physiology, 2017 The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66Shc and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-
Yuyan Xiong +7 more
doaj +8 more sources
L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells [PDF]
Pulmonary Circulation, 2021 The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Matthew S. Douglass +3 more
doaj +6 more sources
Critical role for arginase II in osteoarthritis pathogenesis. [PDF]
Ann Rheum Dis, 2019 Objective Osteoarthritis (OA) appears to be associated with various metabolic disorders, but the potential contribution of amino acid metabolism to OA pathogenesis has not been clearly elucidated.
Choi WS +8 more
europepmc +5 more sources
p32-Dependent p38 MAPK Activation by Arginase II Downregulation Contributes to Endothelial Nitric Oxide Synthase Activation in HUVECs [PDF]
Cells, 2020 Arginase II reciprocally regulates endothelial nitric oxide synthase (eNOS) through a p32-dependent Ca2+ control. We investigated the signaling pathway of arginase II-dependent eNOS phosphorylation. Western blot analysis was applied for examining protein
Bon-Hyeock Koo +3 more
doaj +3 more sources
Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32‐Dependent Manner [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Arginase II activity contributes to reciprocal regulation of endothelial nitric oxide synthase (eNOS). We tested the hypotheses that arginase II activity participates in the regulation of Ca2+/Ca2+/calmodulin‐dependent kinase II/eNOS ...
Bon‐Hyeock Koo +10 more
doaj +3 more sources
Poly (ADP-Ribose) Polymerase 1 Mediated Arginase II Activation Is Responsible for Oxidized LDL-Induced Endothelial Dysfunction [PDF]
Frontiers in Pharmacology, 2018 It is well known that arginase II leads to decreased synthesis of nitric oxide (NO) by competing with endothelial nitric oxide synthase (eNOS) for their same substrate L-arginine.
Qi Wang +10 more
doaj +3 more sources
KCl-Dependent Release of Mitochondrial Membrane-Bound Arginase Appears to Be a Novel Variant of Arginase-II [PDF]
Scientifica, 2016 Arginase regulates arginine metabolism, ornithine-urea cycle, and immunological surveillance. Arginase-I is predominant in cytosol, and arginase-II is localised in the mitochondria.
Mishra Suman, Mishra Rajnikant
doaj +5 more sources
Endothelial arginase II and atherosclerosis [PDF]
Korean Journal of Anesthesiology, 2011 Atherosclerotic vascular disease is the leading cause of morbidity and mortality in developed countries. While it is a complex condition resulting from numerous genetic and environmental factors, it is well recognized that oxidized low-density ...
Sungwoo Ryoo +2 more
doaj +4 more sources