Results 41 to 50 of about 5,115,447 (250)
Ablation of Arginase II Spares Arginine and Abolishes the Arginine Requirement for Growth in Male Mice. [PDF]
J Nutr, 2017 Didelija IC, Mohammad MA, Marini JC.
europepmc +2 more sources
Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene [PDF]
Molecular and Cellular Biology, 2001 Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component of the urea cycle, and inherited defects in arginase I have deleterious consequences in humans. In contrast, the physiologic role of arginase II has not been defined, and no deficiencies in arginase II have been identified in humans. Mice with a disruption in
O, Shi +4 more
openaire +2 more sources
Circulation Research, 2008 Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E–null (ApoE −/− ) and wild-type mice fed a high cholesterol diet.
Sungwoo, Ryoo +20 more
openaire +2 more sources
Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production. [PDF]
PLoS ONE, 2012 Consumption of L-arginine contributes to reduced bioavailability of nitric oxide (NO) that is critical for the development of ischemia-reperfusion injury.
Adrian T Gonon +7 more
doaj +1 more source
Selective endothelial overexpression of arginase II induces endothelial dysfunction and hypertension and enhances atherosclerosis in mice. [PDF]
PLoS ONE, 2012 Cardiovascular disorders associated with endothelial dysfunction, such as atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature can compete with eNOS for L-arginine and has been implicated in atherosclerosis.
Boris L Vaisman +9 more
doaj +1 more source
Role of Arginase 2 as a potential pharmacological target for the creation of new drugs to correct cardiovascular diseases [PDF]
Research Results in Pharmacology, 2020 Introduction: The review provides relevant information about arginase 2, the role of this enzyme in the formation of endothelial dysfunction and, as a consequence, the development of cardiovascular diseases.
Sergey A. Demchenko +2 more
doaj +3 more sources
Sciences of Phytochemistry, 2023 This study aimed to explore the phytochemical profile, heavy metal composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens due to its folkloric acclaimed aphrodisiac use.
Enoch Buba Badgal +2 more
doaj +1 more source
Proteomic identification of mitochondrial targets of arginase in human breast cancer. [PDF]
PLoS ONE, 2013 We have previously reported arginase expression in human breast cancer cells and demonstrated that the inhibition of arginase by N(ω) hydroxy L-arginine (NOHA) in MDA-MB-468 cells induces apoptosis. However, arginase expression and its possible molecular
Rajan Singh +8 more
doaj +1 more source
Journal of Hematology & Oncology, 2008 Background L-arginine is the common substrate for the two isoforms of arginase. Arginase I, highly expressed in the liver and arginase II mainly expressed in the kidney.
Patterson John R +6 more
doaj +1 more source