Results 41 to 50 of about 5,976,322 (209)

Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity. [PDF]

Front Physiol, 2016
Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L-arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase-II (Arg-II) in ...
Huang J, Rajapakse A, Xiong Y, Montani JP, Verrey F, Ming XF, Yang Z.   +6 more
europepmc   +2 more sources

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Correction of morphofunctional disorders with asialoerythropoietin and selective inhibitor of arginase II KUD975 in cases of ischemic kidney damage in the experiment [PDF]

Research Results in Pharmacology, 2018
Introduction: Acute kidney injury (AKI), which is based on ischemic-reperfusion damage, is a widespread life-threatening condition and remains a serious public health problem with a high mortality rate among patients.
Vladislav Elagin, Oleg Bratchikov, Maria Zatolokina   +2 more
doaj   +3 more sources

Disturbance of Arginase Activity and Nitric Oxide Levels in Iraqi Type 2 Diabetes Mellitus

مجلة بغداد للعلوم, 2018
This study is an attempt to find whether arginine metabolism dysregulation by arginase activity is related to hyperglycemia, followed by changes in nitric oxide (NO) generation in type 2 diabetic patients. This study includes 42 control subjects (Group I)
Baghdad Science Journal
doaj   +1 more source

Relationship between arginase activity and renal function in sera of patients with the two types of diabetes mellitus [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2017
Biochemical study was carried out to evaluate the activity of organs in sera of patients with two types of diabetes mellitus-DM ( 1 and 68 of type II ) as compared with healthy individuals as a control group.
Rafah R. Hameed i, Gufran Sh. Ahmed, Tawfeeq F. Al-Auqb   +2 more
doaj   +1 more source

Arginase pathway in human endothelial cells in pathophysiological conditions.

, 2004
Objective. – Arginase is a nitric oxide synthase-alternative pathway for L-arginine breakdown leading to biosynthesis of urea and L-ornithine. Arginase pathway is inducible by inflammatory molecules—such as cytokines and bacterial endotoxin—in ...
CURELLO S, GRIGOLATO P, GRIGOLATO, Pier Giovanni, COMINI L, ALBERTINI A, BASTIANON D, FRANCOLINI G, FINAZZI D, VALETTI B, SUZUKI, Hisanori, FERRARI R., FINAZZI, Dario, BACHETTI T, SUZUKI H, CADEI M   +14 more
core   +2 more sources

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Ang II increases arginase activity/expression and reduces NO production.

, 2015
(A) Western blot result for arginase 1 expression, (B) arginase activity (colorimetric assay) and (C) NO production were measured in RASMCs after control, Ang II (1μM), Ang II+ABH, or L-NAME (1mM) treatment. Arginase activity in control cells was 714.4 ±
Anil Bhatta (711955), R. William Caldwell (447345), Zhimin Xu (88210), Lin Yao (332529), Ruth B. Caldwell (347665), Haroldo A. Toque (447341), Alia Shatanawi (711956)   +6 more
core   +1 more source