Results 51 to 60 of about 5,115,447 (250)

Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. [PDF]

PLoS ONE, 2010
Increased catabolism of arginine by arginase is increasingly viewed as an important pathophysiological factor in cardiovascular disease, including atherosclerosis induced by high cholesterol diets.
Aaron Erdely, Diane Kepka-Lenhart, Rebecca Salmen-Muniz, Rebecca Chapman, Tracy Hulderman, Michael Kashon, Petia P Simeonova, Sidney M Morris   +7 more
doaj   +1 more source

Expression of arginase II in prostate cancer

International Journal of Oncology, 2008
Previous reports have shown elevated arginase activity in prostate cancer patients. This study was designed to compare expression levels of arginase II (AII) in various human prostate cancer cell lines and tissues. Expression levels of AII and other enzymes involved in arginine metabolism were examined in androgen-dependent (LNCaP, LAPC-4) and androgen-
Shannon M, Mumenthaler, Hong, Yu, Sheila, Tze, Stephen D, Cederbaum, Anthony E, Pegg, David B, Seligson, Wayne W, Grody   +6 more
openaire   +3 more sources

A synthetic peptide as an allosteric inhibitor of human arginase I and II [PDF]

Molecular Biology Reports, 2021
AbstractArginine metabolism mediated by arginases plays a critical role in cell and tissue function. The arginine hydrolysis is deeply involved in the urea cycle, which helps the kidney excrete ammonia from blood. Upregulation of arginases affects microenvironment stability due to the presence of excess urea in blood.
Kai Gao, Sergey Lunev, Mariska P. M. van den Berg, Zayana M. Al-Dahmani, Stephen Evans, Dyon A. L. J. Mertens, Herman Meurs, Reinoud Gosens, Matthew R. Groves   +8 more
openaire   +3 more sources

Possible Involvement of Altered Arginase Activity, Arginase Type I and Type II Expressions, and Nitric Oxide Production in Occurrence of Intimal Hyperplasia in Premenopausal Human Uterine Arteries

Journal of Pharmacological Sciences, 2008
In the present experiments, we tried to elucidate whether changes in arginase activity and protein expression of arginase I and II are involved in the occurrence of intimal hyperplasia in premenopausal human uterine arteries.
Galina Vasileva Marinova, Renzo Ygor Loyaga-Rendon, Satoshi Obayashi, Tomoko Ishibashi, Toshiro Kubota, Masatoshi Imamura, Hiroshi Azuma   +6 more
doaj   +1 more source

Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice

BMC Immunology, 2009
Background Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice.
Rothenberg Marc E, Wills-Karp Marsha, O'Brien William E, Cederbaum Stephen D, Hajek Amanda R, Collier Ann R, Niese Kathryn A, Zimmermann Nives   +7 more
doaj   +1 more source

Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling

Journal of Cellular Physiology, 2020
Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of ...
Yi Yu, Diogo Ladeiras, Yuyan Xiong, K. F. Boligan, Xiujie Liang, S. von Gunten, R. Hunger, X. Ming, Zhihong Yang   +8 more
semanticscholar   +1 more source

Helicobacter pylori arginase mutant colonizes arginase II knockout mice

World Journal of Gastroenterology, 2011
To investigate the role of host and bacterial arginases in the colonization of mice by Helicobacter pylori (H. pylori).H. pylori produces a very powerful urease that hydrolyzes urea to carbon dioxide and ammonium, which neutralizes acid. Urease is absolutely essential to H.
Songhee H, Kim, Melanie L, Langford, Jean-Luc, Boucher, Traci L, Testerman, David J, McGee   +4 more
openaire   +2 more sources

Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline

BMC Cardiovascular Disorders, 2009
Background Pharmacological inhibition of endothelial arginase-II has been shown to improve endothelial nitric oxide synthase (eNOS) function and reduce atherogenesis in animal models.
Ruffieux Jean, Carvas João, Rajapakse Angana, Ming Xiu-Fen, Yang Zhihong   +4 more
doaj   +1 more source

Study of the effect of acetylsalicylic acid and a selective arginase II inhibitor KUD 975 on the correction of hemostatic disorders in experimental preeclampsia [PDF]

Research Results in Pharmacology, 2022
Introduction: The disruption of the functional state of the vascular endothelium is among the main causes of preeclampsia, which is one of the most common causes of maternal and perinatal mortality.
Anastasia V. Gureeva, Olga V. Severinova, Vladimir V. Gureev, Indira S. Kochkarova, Elena V. Avdeyeva   +4 more
doaj   +3 more sources

Role of arginase in vessel wall remodeling

Frontiers in Immunology, 2013
Arginase metabolizes the semi-essential amino acid L-arginine to L-ornithine and urea. There are two distinct isoforms of arginase, arginase I and II, which are encoded by separate genes and display differences in tissue distribution, subcellular ...
William eDurante
doaj   +1 more source