Rat liver arginase system under acetaminophen-induced toxic injury and protein deprivation [PDF]
The Ukrainian Biochemical Journal, 2017 Arginase activity and L-arginine content in both cytosolic and mitochondrial fractions of rat liver cells under the conditions of toxic injury on the background of protein deprivation was studied.
H. P. Kopylchuk +2 more
doaj +1 more source
Unique hepatic cytosolic arginase evolved independently in ureogenic freshwater air-breathing teleost, Heteropneustes fossilis. [PDF]
PLoS ONE, 2013 Hepatic cytosolic arginase (ARG I), an enzyme of the urea cycle operating in the liver of ureotelic animals, is reported to be present in an ammoniotelic freshwater air-breathing teleost, Heteropneustes fossilis which has ureogenic potential.
Shilpee Srivastava, B K Ratha
doaj +1 more source
STUDYING DOSE-DEPENDENT ENDOTHELIO- AND CARDIOPROTECTIVE ACTIVITY OF SELECTIVE ARGINASE II INHIBITOR IN HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION [PDF]
Research Results in Pharmacology, 2016 This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction.
Vladimir Yakushev +5 more
doaj +3 more sources
Journal of Translational Medicine, 2003 Background Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-γ (rIFN-γ), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC).
Gallardo Stacie T +5 more
doaj +1 more source
Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function. [PDF]
PLoS ONE, 2015 Arterial stiffness (AS) is an independent risk factor for cardiovascular morbidity/mortality. Smooth muscle cell (SMC) proliferation and increased collagen synthesis are key features in development of AS.
Anil Bhatta +6 more
doaj +1 more source
Inhibition of p38mapk Reduces Adipose Tissue Inflammation in Aging Mediated by Arginase-II
Pharmacology, 2020 Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue ...
Ji Huang +3 more
semanticscholar +1 more source
Relationship between arginase activity and renal function in sera of patients with the two types of diabetes mellitus [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2017 Biochemical study was carried out to evaluate the activity of organs in sera of patients with two types of diabetes mellitus-DM ( 1 and 68 of type II ) as compared with healthy individuals as a control group.
Rafah R. Hameed i +2 more
doaj +1 more source
A Model to Study the Inhibition of Arginase II with Noscapine & Its Derivatives
Protein Research & Bioinformatics, 2020 Background and Purpose Nitrate tolerance can be explained based on the reduction of the vessel responsiveness and the same is used for endogenous vasodilator Nitric Oxide (NO). There are some limitations for the treatment of ischaemia, angina etc. and it
Prashant Singh
semanticscholar +1 more source
Disturbance of Arginase Activity and Nitric Oxide Levels in Iraqi Type 2 Diabetes Mellitus
مجلة بغداد للعلوم, 2018 This study is an attempt to find whether arginine metabolism dysregulation by arginase activity is related to hyperglycemia, followed by changes in nitric oxide (NO) generation in type 2 diabetic patients. This study includes 42 control subjects (Group I)
Baghdad Science Journal
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Macrophage membrane‐coated Cu/Zn‐MOF nanozyme microneedles (MNs) reprogram the diabetic wound microenvironment through localized, minimally invasive delivery. By suppressing M1‐like macrophage activation while promoting extracellular matrix deposition and angiogenesis, this biomimetic platform accelerates diabetic wound repair.
Qipeng Wu +7 more
wiley +1 more source