Results 1 to 10 of about 39,646 (166)
Role of Arginase in Vessel Wall Remodeling
Frontiers in Immunology, 2013 Arginase metabolizes the semi-essential amino acid L-arginine to L-ornithine and urea. There are two distinct isoforms of arginase, arginase I and II, which are encoded by separate genes and display differences in tissue distribution, subcellular ...
William Durante, Durante William
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Methylglyoxal-Modified Albumin Effects on Endothelial Arginase Enzyme and Vascular Function
Cells, 2023 Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction (VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is produced by endothelial NO synthase (eNOS) from L-arginine.
Ebaa M. Alzayadneh +3 more
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Impact of suitable control on a uniform interpretation of units for arginase assay
Biochemistry and Biophysics Reports, 2021 The arginase catalyzes the conversion of arginine into ornithine and urea. The activity of arginase serves as a critical diagnostic marker for several pathophysiological conditions.
Mishra Suman, Mishra Rajnikant
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Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. [PDF]
PLoS ONE, 2010 Increased catabolism of arginine by arginase is increasingly viewed as an important pathophysiological factor in cardiovascular disease, including atherosclerosis induced by high cholesterol diets.
Aaron Erdely +7 more
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Brazilian Archives of Biology and Technology, 2022 Arginase plays an imperative role in the cell growth and proliferation of healthy cells under normal physiological conditions. Recently arginase has gained the sight of many researchers as it has emerged as a potential candidate for auxotrophic cancer ...
Himanshi Gautam +2 more
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Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases
Cell Death Discovery, 2022 Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform significant roles in the regulation of cellular functions in cardiovascular system,
Zhuozhuo Li +8 more
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SCREENING AND PRODUCTION OF MICROBIAL L-ARGINASE ENZYME AS ANTICANCER AGENT FROM DIFFERENT SOIL ENVIRONMENTS IN EGYPT [PDF]
Ain Shams Medical Journal, 2022 Background: Hydrolysis of L-arginine to L-ornithine and urea is catalyzed by the crucial L-arginase enzyme. L-arginase nowadays is necessary for medicine due to its significance as an anticancer agent against auxotrophic cancers to arginine.
Mohammed Kassab
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Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production. [PDF]
PLoS ONE, 2012 Consumption of L-arginine contributes to reduced bioavailability of nitric oxide (NO) that is critical for the development of ischemia-reperfusion injury.
Adrian T Gonon +7 more
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Frontiers in Immunology, 2021 Myeloid cell arginase-mediated arginine depletion with consecutive inhibition of T cell functions is a key component of tumor immune escape. Both, granulocytic myeloid-derived suppressor cells (G-MDSC) and conventional mature human polymorphonuclear ...
Verena Vonwirth +17 more
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BMC Immunology, 2009 Background Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice.
Rothenberg Marc E +7 more
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