Results 41 to 50 of about 39,646 (166)
Respiratory Research, 2011 Background Arginase overexpression contributes to airways hyperresponsiveness (AHR) in asthma. Arginase expression is further augmented in cigarette smoking asthmatics, suggesting that it may be upregulated by environmental pollution.
Amatullah Hajera +6 more
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Molecular Genetics and Metabolism Reports, 2021 Arginase deficiency is a rare inborn error of metabolism that interrupts the final step of the urea cycle. Untreated individuals often present with episodic hyperammonemia, developmental delay, cognitive impairment, and spasticity in early childhood. The
Yue Huang +14 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Arginase II activity contributes to reciprocal regulation of endothelial nitric oxide synthase (eNOS). We tested the hypotheses that arginase II activity participates in the regulation of Ca2+/Ca2+/calmodulin‐dependent kinase II/eNOS ...
Bon‐Hyeock Koo +10 more
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Structure and Function of Arginases [PDF]
The Journal of Nutrition, 2004 The arginases catalyze the divalent cation dependent hydrolysis of L-arginine to produce L-ornithine and urea. Although traditionally considered in terms of its role as the final enzyme of the urea cycle, the enzyme is found in a variety of nonhepatic tissues.
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Experimental Biology and Medicine, 1980 SummaryMouse peritoneal macrophages in culture released a macromolecular factor capable of inhibiting mouse L1210 lymphoma cells in vitro. The factor was proved to be arginase by several criteria. The inhibition was reversed by adding arginine or citrulline to culture, the arginine in the culture medium was consumed, and the guanido group of arginine ...
Chen, P C, Broome, J D
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Arginine/Arginase NO NO NO [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Arginine is a semi-essential amino acid that plays a critical role in several metabolic pathways. The best known of these is as the immediate precursor of urea in the liver and to a lesser extent in the intestine.1 The enzyme responsible for the cleavage of arginine to produce urea is arginase, which is the only enzyme in the urea cycle that comes in ...
Godfrey S. Getz, Catherine A. Reardon
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RETRACTED: Arginase II - a new target in the development of endothelium protectors
Регуляторные исследования и экспертиза лекарственных средств, 2018 RETRACTED ARTICLEThe article describes arginase’s role in pathogenesis of endothelial dysfunction and a number of cardio-vascular diseases. Arginase catalyzes the hydrolysis of L-arginine, the substrate for nitric oxide synthesis, to L-ornithine and urea.
V. I. Yakushev +6 more
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Frontiers in Immunology, 2019 Immunity to intestinal helminths is known to require both innate and adaptive components of the immune system activated along the Type 2 IL-4R/STAT6-dependent pathway.
Kara J. Filbey +11 more
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Protein & Cell, 2016 Development of alternatively activated (M2) macrophage phenotypes is a complex process that is coordinately regulated by a plethora of pathways and factors.
Julia Foldi +4 more
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Molecular Therapy: Nucleic Acids, 2016 Urea cycle disorders are incurable enzymopathies that affect nitrogen metabolism and typically lead to hyperammonemia. Arginase deficiency results from a mutation in Arg1, the enzyme regulating the final step of ureagenesis and typically results in ...
Patrick C Lee +14 more
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