Results 31 to 40 of about 39,646 (166)

Hyperargininemia with Arginase Deficiency [PDF]

Pediatric Research, 1979
Summary: A female and a male sibling aged 15 and 8 yr developed almost normally for 3 yr, then gradually deteriorated intellectually and physically. Both patients showed marked hyperargininuria (up to 370 times normal), prominent lysinuria, cystinuria, and ornithinuria, and a milder generalized amino aciduria.
S D, Cederbaum, K N, Shaw, E B, Spector, M A, Verity, P J, Snodgrass, G I, Sugarman   +5 more
openaire   +2 more sources

Disturbance of Arginase Activity and Nitric Oxide Levels in Iraqi Type 2 Diabetes Mellitus

مجلة بغداد للعلوم, 2018
This study is an attempt to find whether arginine metabolism dysregulation by arginase activity is related to hyperglycemia, followed by changes in nitric oxide (NO) generation in type 2 diabetic patients. This study includes 42 control subjects (Group I)
Baghdad Science Journal
doaj   +1 more source

rIFN-γ-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition

Journal of Translational Medicine, 2003
Background Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-γ (rIFN-γ), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC).
Gallardo Stacie T, Melicharová Karolina, Patenia Rebecca, Hu Wei, Melichar Bohuslav, Freedman Ralph   +5 more
doaj   +1 more source

Possible Involvement of Altered Arginase Activity, Arginase Type I and Type II Expressions, and Nitric Oxide Production in Occurrence of Intimal Hyperplasia in Premenopausal Human Uterine Arteries

Journal of Pharmacological Sciences, 2008
In the present experiments, we tried to elucidate whether changes in arginase activity and protein expression of arginase I and II are involved in the occurrence of intimal hyperplasia in premenopausal human uterine arteries.
Galina Vasileva Marinova, Renzo Ygor Loyaga-Rendon, Satoshi Obayashi, Tomoko Ishibashi, Toshiro Kubota, Masatoshi Imamura, Hiroshi Azuma   +6 more
doaj   +1 more source

Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Frontiers in Chemistry, 2021
Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase may ...
Andreza R. Garcia, Danielle M. P. Oliveira, Jessica B. Jesus, Jessica B. Jesus, Alessandra M. T. Souza, Ana Carolina R. Sodero, Alane B. Vermelho, Ivana C. R. Leal, Rodrigo Octavio M. A. Souza, Leandro S. M. Miranda, Anderson S. Pinheiro, Igor A. Rodrigues, Igor A. Rodrigues   +12 more
doaj   +1 more source

Detrimental Effects of Chronic L-Arginine Rich Food on Aging Kidney

Frontiers in Pharmacology, 2021
The impaired L-arginine/nitric oxide pathway is a well-recognized mechanism for cardiovascular and renal diseases with aging. Therefore, supplementation of L-arginine is widely proposed to boost health or as adjunct therapy for the patients.
Ji Huang, Ji Huang, Diogo Ladeiras, Diogo Ladeiras, Yi Yu, Xiu-Fen Ming, Xiu-Fen Ming, Zhihong Yang, Zhihong Yang   +8 more
doaj   +1 more source

The kinetic properties of arginase in sperm cells of inferile men

Regulatory Mechanisms in Biosystems, 2018
Nowadays the role of NO in the development of male infertility is actively studied. Arginase (EC 3.5.3.1) is a manganese metalloenzyme which converts L-arginine to L-ornithine and urea and reciprocally regulates NO production.
R. V. Fafula, U. P. Iefremova, O. K. Onufrovych, H. V. Maksymyuk, D. Z. Vorobets, Z. D. Vorobets   +5 more
doaj   +1 more source

Arginase‐flotillin interaction brings arginase to red blood cell membrane [PDF]

FEBS Letters, 2006
Flotillin‐1 and arginase are both up‐regulated in red blood cell membrane of type 2 diabetic patients. For studying why the soluble arginase can bind to the membrane and whether such binding would modify arginase activity, the arginase1 and related proteins were cloned and expressed.
Jiang, Ming, Ding, Yu, Su, Yang, Hu, Xiaojian, Li, Jinying, Zhang, Zhihong   +5 more
openaire   +2 more sources

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

Journal for ImmunoTherapy of Cancer, 2019
Background Tumor orchestrated metabolic changes in the microenvironment limit generation of anti-tumor immune responses. Availability of arginine, a semi-essential amino acid, is critical for lymphocyte proliferation and function.
Juan J. Miret, Paul Kirschmeier, Shohei Koyama, Mingrui Zhu, Yvonne Y. Li, Yujiro Naito, Min Wu, Venkat S. Malladi, Wei Huang, William Walker, Sangeetha Palakurthi, Glenn Dranoff, Peter S. Hammerman, Chad V. Pecot, Kwok-Kin Wong, Esra A. Akbay   +15 more
doaj   +1 more source

Arginase and vascular aging

Journal of Applied Physiology, 2008
Vascular and associated ventricular stiffness is one of the hallmarks of the aging cardiovascular system. Both an increase in reactive oxygen species production and a decrease in nitric oxide (NO) bioavailability contribute to the endothelial dysfunction that underlies this vascular stiffness, independent of other age-related vascular pathologies such ...
Lakshmi, Santhanam, David W, Christianson, Daniel, Nyhan, Dan E, Berkowitz   +3 more
openaire   +3 more sources