Results 31 to 40 of about 50,915 (302)
Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion. [PDF]
, 2013 Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase.
Hundemer, Michael +63 more
core +2 more sources
Evaluation of optimal conditions for arginase activity in streptozotocin induced diabetic rats
Veterinární Medicína, 2005 The assay conditions needed to achieve maximal activity of liver and kidney arginase in diabetic and non-diabetic rats were investigated and compared.
M. Erisir, E. Ercel, S. Yilmaz, S. Ozan
doaj +1 more source
Role of Arginase 2 as a potential pharmacological target for the creation of new drugs to correct cardiovascular diseases [PDF]
Research Results in Pharmacology, 2020 Introduction: The review provides relevant information about arginase 2, the role of this enzyme in the formation of endothelial dysfunction and, as a consequence, the development of cardiovascular diseases.
Sergey A. Demchenko +2 more
doaj +3 more sources
Molecular Genetics and Metabolism Reports, 2021 Arginase deficiency is a rare inborn error of metabolism that interrupts the final step of the urea cycle. Untreated individuals often present with episodic hyperammonemia, developmental delay, cognitive impairment, and spasticity in early childhood. The
Yue Huang +14 more
doaj +1 more source
POLARIZED ACTIVATION OF HUMAN PERIPHERAL BLOOD PHAGOCYTES BY BACTERIOPHAGE–DERIVED DOUBLE-STRANDED RNA (LARIFAN) IN VITRO [PDF]
Biotechnologia Acta, 2023 Aim. This study aimed to examine the effect of Larifan on metabolic characteristics of human blood monocytes and granulocytes in vitro. Methods. Four healthy adult men aged 21-26 years were recruited to participate in the study as blood donors.
R. Dovhyi +8 more
doaj +1 more source
Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II
Cellular Physiology and Biochemistry, 2016 Background/Aims: Despite significant advancements in the diagnosis and treatment of osteosarcoma, the overall survival has remained relatively unchanged for over two decades.
Bhuvana A. Setty +5 more
doaj +1 more source
Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. [PDF]
PLoS ONE, 2015 Arginase-1 catalyzes the conversion of arginine to ornithine and urea, which is the final step of the urea cycle used to remove excess ammonia from the body.
Laurel L Ballantyne +9 more
doaj +1 more source
Disturbance of Arginase Activity and Nitric Oxide Levels in Iraqi Type 2 Diabetes Mellitus
مجلة بغداد للعلوم, 2018 This study is an attempt to find whether arginine metabolism dysregulation by arginase activity is related to hyperglycemia, followed by changes in nitric oxide (NO) generation in type 2 diabetic patients. This study includes 42 control subjects (Group I)
Baghdad Science Journal
doaj +1 more source
Pathogens, 2022 Arginase is a metalloenzyme that plays a central role in Leishmania infections. Previously, rosmarinic and caffeic acids were described as antileishmanial agents and as Leishmania amazonensis arginase inhibitors.
Julio Abel Alfredo dos Santos Simone Come +6 more
doaj +1 more source
Journal of Translational Medicine, 2003 Background Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-γ (rIFN-γ), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC).
Gallardo Stacie T +5 more
doaj +1 more source