Results 11 to 20 of about 39,646 (166)
Arginase as a mediator of diabetic retinopathy [PDF]
Frontiers in Immunology, 2013 We have shown previously that diabetes causes increases in retinal arginase activity that are associated with impairment of endothelial cell (EC)-dependent vasodilation and increased formation of the peroxynitrite biomarker nitrotyrosine.
Chintan ePatel +10 more
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Progress in Retinal and Eye Research, 2013 Ischemic retinopathies, such as diabetic retinopathy (DR), retinopathy of prematurity and retinal vein occlusion are a major cause of blindness in developed nations worldwide. Each of these conditions is associated with early neurovascular dysfunction.
S Priya, Narayanan +5 more
openaire +2 more sources
Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo
Molecular Therapy: Methods & Clinical Development, 2020 Arginase is a complex and unique enzyme that plays diverse roles in health and disease. By metabolizing arginine, it can shape the outcome of innate and adaptive immune responses. The immunomodulatory capabilities of arginase could potentially be applied
Makan Khoshnejad +12 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease. One of the early signs of T2DM associated cardiovascular events is the development of vascular dysfunction.
Alia Shatanawi +5 more
doaj +1 more source
Veterinary Sciences, 2022 Immunosuppressive myeloid cells in the tumor microenvironment play a major role in suppressing tumor immunity via the production of arginase, IL-10, and others.
Aimee M. Soileau +4 more
doaj +1 more source
Crystallization of Arginase [PDF]
Nature, 1946 ATTEMPTS to obtain arginase in a pure state were only partly successful and resulted in an approximately twenty-fold purification of the enzyme from liver extracts1,2,3.
openaire +2 more sources
ARGINASE ACTIVITY IN BREAST CANCER: IS IT A SIGNIFICANT BIOMARKER? [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2009 Due to the importance of arginase enzyme in different malignant disorders, the purpose ofthe present study was to determine and compare the arginase activity in cancerous cells andtheir normal and benign counterparts.
Doaa Maximous +4 more
doaj +1 more source
Journal of Hematology & Oncology, 2008 Background L-arginine is the common substrate for the two isoforms of arginase. Arginase I, highly expressed in the liver and arginase II mainly expressed in the kidney.
Patterson John R +6 more
doaj +1 more source
Diagnostics, 2021 Arginase-1 catalyzes the conversion of arginine to ornithine and urea. Because of its predominant expression in hepatocytes, it serves as a marker for hepatocellular carcinoma, although other tumor entities can also express arginase-1. To comprehensively
Maximilian Lennartz +24 more
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POLARIZED ACTIVATION OF HUMAN PERIPHERAL BLOOD PHAGOCYTES BY BACTERIOPHAGE–DERIVED DOUBLE-STRANDED RNA (LARIFAN) IN VITRO [PDF]
Biotechnologia Acta, 2023 Aim. This study aimed to examine the effect of Larifan on metabolic characteristics of human blood monocytes and granulocytes in vitro. Methods. Four healthy adult men aged 21-26 years were recruited to participate in the study as blood donors.
R. Dovhyi +8 more
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