Results 11 to 20 of about 50,915 (302)

KCl-Dependent Release of Mitochondrial Membrane-Bound Arginase Appears to Be a Novel Variant of Arginase-II [PDF]

Scientifica, 2016
Arginase regulates arginine metabolism, ornithine-urea cycle, and immunological surveillance. Arginase-I is predominant in cytosol, and arginase-II is localised in the mitochondria.
Mishra Suman, Mishra Rajnikant
doaj   +2 more sources

Frequent adaptive immune responses against arginase-1

OncoImmunology, 2018
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite, Rasmus Erik Johansson Mortensen, Morten Hansen, Morten Orebo Holmström, Shamaila Munir Ahmad, Nicolai Grønne Dahlager Jørgensen, Özcan Met, Marco Donia, Inge Marie Svane, Mads Hald Andersen   +9 more
doaj   +2 more sources

Role of arginase in vessel wall remodeling [PDF]

Frontiers in Immunology, 2013
Arginase metabolizes the semi-essential amino acid L-arginine to L-ornithine and urea. There are two distinct isoforms of arginase, arginase I and II, which are encoded by separate genes and display differences in tissue distribution, subcellular ...
William eDurante
doaj   +2 more sources

Arginase as a mediator of diabetic retinopathy [PDF]

Frontiers in Immunology, 2013
We have shown previously that diabetes causes increases in retinal arginase activity that are associated with impairment of endothelial cell (EC)-dependent vasodilation and increased formation of the peroxynitrite biomarker nitrotyrosine.
Chintan ePatel, Modesto eRojas, S. Priya eNarayanan, Wenbo eZhang, Wenbo eZhang, Zhimin eXu, Tahira elemtalsi, Kanjana eJittiporn, Robert William Caldwell, Ruth B Caldwell, Ruth B Caldwell   +10 more
doaj   +3 more sources

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana [PDF]

, 2010
In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses.
Juliane Schroeder, Plevin Robin, Kurnik Magdalena, H. Adrienne McGachy, Shweash, M.S., Cadalbert Laurence C., H Adrienne McGachy, Callum M Sloss, James Alexander, Shweash Muhannad, Bryant, C.E., Laurence C Cadalbert, Cadalbert, L.C., Clare E Bryant, Laurence C. Cadalbert, Alexander, James, Mashael S Al-Mutairi, Muhannad Shweash, Al-Mutairi Mashael S., Al-Mutairi, M.S., Schroeder Juliane, Callum M. Sloss, Alexander James, Robin Plevin, Sloss Callum M., Schroeder, J., Plevin, R.J., Sloss, C.M., Mashael S. Al-Mutairi, McGachy, H.A., Clare E. Bryant, McGachy H. Adrienne, Bryant Clare E., Magdalena Kurnik, Kurnik, M.   +34 more
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Arginase in retinopathy [PDF]

Progress in Retinal and Eye Research, 2013
Ischemic retinopathies, such as diabetic retinopathy (DR), retinopathy of prematurity and retinal vein occlusion are a major cause of blindness in developed nations worldwide. Each of these conditions is associated with early neurovascular dysfunction.
S Priya, Narayanan, Modesto, Rojas, Jutamas, Suwanpradid, Haroldo A, Toque, R William, Caldwell, Ruth B, Caldwell   +5 more
openaire   +2 more sources

Mapping Arginase Expression with ¹⁸F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary α-Amino Acids [PDF]

, 2021
Arginase hydrolyzes L-arginine and influences levels of polyamines and nitric oxide. Arginase overexpression is associated with inflammation and tumorigenesis.
Kurhade, Santosh, Meurs, Herman, Gosens, Reinoud, Elsinga, Philip H, Dömling, Alexander, Berg, Mariska van den, Clemente, Gonçalo S; id_orcid, F Antunes, Inês; id_orcid, Sijbesma, Jürgen W A; id_orcid, Waarde, Aren van; id_orcid, Willemsen-Seegers, Nicole, Buijsmam, Rogier C, Philip H. Elsinga, Rogier C. Buijsman, Gonçalo S. Clemente, Mariska P.M. van den Berg, Inês F. Antunes, Alexander Dömling, Reinoud Gosens, Nicole Willemsen-Seegers, Herman Meurs, Santosh Kurhade, Jürgen W.A. Sijbesma, Aren van Waarde   +23 more
core   +1 more source

Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia. [PDF]

, 2013
The underlying mechanisms resulting in the profound immune suppression characteristic of human visceral leishmaniasis (VL) are not fully understood. Here, we tested the hypothesis that arginase, an enzyme associated with immunosuppression, is higher in ...
Corset, C, Cloke Tom, Closs Ellen, Cloke, T, Yifru Sisay, Abebe Tamrat, Corset, M, Modolell, M, Takele, Yegnasew, Corware, Karina, Cloke, Tom, Sisay Yifru, Hailu, Workagegnehu, Munder, M, Tacchini-Cottier, F, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Weldegebreal, T, Weldegebreal Teklu, Teklu Weldegebreal, Closs, E, Sisay, Y, Hailu, W, Mueller, I, Pascale Kropf, Camille Corset, Müller Ingrid, Sisay, Yifru, Takele Yegnasew, Closs, Ellen, Karina Corware, Weldegebreal, Teklu, Modolell, Manuel, Corware, K, Asrat Hailu, Corware Karina, Abebe, T, Corset Margaux, Munder, Markus, Manuel Modolell, Hailu Workagegnehu, Hailu, A, Margaux Corset, Modolell Manuel, Workagegnehu Hailu, Kropf Pascale, Abebe, Tamrat, Tacchini-Cottier, Fabienne, Fabienne Tacchini-Cottier, Yegnasew Takele, Kropf, Pascale, Corset Camille, Munder Markus, Tom Cloke, Corset, Margaux, Ellen Closs, Tacchini-Cottier Fabienne, Hailu Asrat, Corset, Camille, Hailu, Asrat, Takele, Y, Tamrat Abebe, Closs, E., Abebe, T., Corset, C., Takele, Y., Sisay, Y., Hailu, A., Müller, I., Weldegebreal, T., Corset, M., Corware, K., Cloke, T., Modolell, M., Munder, M., Kropf, P., Tacchini-Cottier, F., Hailu, W.   +79 more
core   +1 more source

Arginase from kiwifruit: properties and seasonal variation [PDF]

, 1997
The in vitro activity of arginase (EC 3.5.3.1) was investigated in youngest-mature leaves and roots (1-3 mm diameter) of kiwifruit vines (Actinidia deliciosa var. deliciosa) during an annual growth cycle, and enzyme from root material partially purified.
Petach, Helen H., C. A. Hale, C. J. Clark, H. H. Petach, Clark, Christopher J., Daniel, Roy M., R. M. Daniel, Hale, C.A.   +7 more
core   +1 more source

Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia. [PDF]

, 2012
BACKGROUND: Cutaneous leishmaniasis is a vector-borne disease that is in Ethiopia mainly caused by the parasite Leishmania aethiopica. This neglected tropical disease is common in rural areas and causes serious morbidity.
Cloke, T, Abebe Tamrat, Mekonen Woinshet, Modolell, M, Thomas Cloke, Woldeyes Mihretu, Seich Al Basatena, Nafisa-Katrin, Abebe, T., Corware, Karina, Bilcha, K, Seich al Basatena, N., Munder, M, Lionel Fry, Tacchini-Cottier, F, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Bilcha, K., Fry Lionel, Seich Al Basatena, N.K., Cloke Thomas, Hailu, A., Cloke, Thomas, Mueller, I, Mihretu Woldeyes, Pascale Kropf, Müller Ingrid, Mekonen, Woinshet, Karina Corware, Modolell, Manuel, al Basatena, N-KS, Müller, I., Woldeyes, M, Woinshet Mekonen, Corware, K, Asrat Hailu, Kassahun Bilcha, Corware Karina, Abebe, T, Woldeyes, Mihretu, Munder, Markus, Manuel Modolell, Mekonen, W., Hailu, A, Modolell Manuel, Fry, Lionel, Kropf Pascale, Abebe, Tamrat, Fry, L., Fry, L, Corware, K., Cloke, T., Modolell, M., Munder, M., Tacchini-Cottier, Fabienne, Fabienne Tacchini-Cottier, Kropf, P., Kropf, Pascale, Bilcha, Kassahun, Tacchini-Cottier, F., Woldeyes, M., Munder Markus, Nafisa-Katrin Seich Al Basatena, Mekonen, W, Tacchini-Cottier Fabienne, Hailu Asrat, Hailu, Asrat, Tamrat Abebe, Bilcha Kassahun, Seich al Basatena Nafisa-Katrin   +70 more
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