Results 11 to 20 of about 1,970 (212)

Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice

BMC Immunology, 2009
Background Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice.
Rothenberg Marc E, Wills-Karp Marsha, O'Brien William E, Cederbaum Stephen D, Hajek Amanda R, Collier Ann R, Niese Kathryn A, Zimmermann Nives   +7 more
doaj   +1 more source

Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo

Molecular Therapy: Methods & Clinical Development, 2020
Arginase is a complex and unique enzyme that plays diverse roles in health and disease. By metabolizing arginine, it can shape the outcome of innate and adaptive immune responses. The immunomodulatory capabilities of arginase could potentially be applied
Makan Khoshnejad, Alfredo Perales-Puchalt, Yaya Dia, Peng Xiao, Ami Patel, Ziyang Xu, Xizhou Zhu, Kun Yun, Ishana Baboo, Rehman Qureshi, Laurent Humeau, Kar Muthumani, David B. Weiner   +12 more
doaj   +1 more source

L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes

Frontiers in Pharmacology, 2020
Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease. One of the early signs of T2DM associated cardiovascular events is the development of vascular dysfunction.
Alia Shatanawi, Munther S. Momani, Ruaa Al-Aqtash, Mohammad H Hamdan, Mohammad H Hamdan, Munir N. Gharaibeh   +5 more
doaj   +1 more source

Crystallization of Arginase [PDF]

Nature, 1946
ATTEMPTS to obtain arginase in a pure state were only partly successful and resulted in an approximately twenty-fold purification of the enzyme from liver extracts1,2,3.
openaire   +2 more sources

ARGINASE ACTIVITY IN BREAST CANCER: IS IT A SIGNIFICANT BIOMARKER? [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2009
Due to the importance of arginase enzyme in different malignant disorders, the purpose ofthe present study was to determine and compare the arginase activity in cancerous cells andtheir normal and benign counterparts.
Doaa Maximous, Madeha Zakhary, Manal Mandour, Sahar El-Said, Amal Mahmoud   +4 more
doaj   +1 more source

The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages

Veterinary Sciences, 2022
Immunosuppressive myeloid cells in the tumor microenvironment play a major role in suppressing tumor immunity via the production of arginase, IL-10, and others.
Aimee M. Soileau, Cally N. Quick, Cambri E. Moeller, Jessica C. Schaumburg, Sita S. Withers   +4 more
doaj   +1 more source

Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma

Journal of Hematology & Oncology, 2008
Background L-arginine is the common substrate for the two isoforms of arginase. Arginase I, highly expressed in the liver and arginase II mainly expressed in the kidney.
Patterson John R, Metoyer Toye, Caldas Yupanqui A, Vonderhaar Derek J, Tate David J, Aviles Diego H, Zea Arnold H   +6 more
doaj   +1 more source

Large-Scale Tissue Microarray Evaluation Corroborates High Specificity of High-Level Arginase-1 Immunostaining for Hepatocellular Carcinoma

Diagnostics, 2021
Arginase-1 catalyzes the conversion of arginine to ornithine and urea. Because of its predominant expression in hepatocytes, it serves as a marker for hepatocellular carcinoma, although other tumor entities can also express arginase-1. To comprehensively
Maximilian Lennartz, Eva Gehrig, Sören Weidemann, Natalia Gorbokon, Anne Menz, Franziska Büscheck, Claudia Hube-Magg, Andrea Hinsch, Viktor Reiswich, Doris Höflmayer, Christoph Fraune, Frank Jacobsen, Christian Bernreuther, Patrick Lebok, Guido Sauter, Waldemar Wilczak, Stefan Steurer, Eike Burandt, Andreas H. Marx, Ronald Simon, Till Krech, Till S. Clauditz, Sarah Minner, David Dum, Ria Uhlig   +24 more
doaj   +1 more source

KCl-Dependent Release of Mitochondrial Membrane-Bound Arginase Appears to Be a Novel Variant of Arginase-II

Scientifica, 2016
Arginase regulates arginine metabolism, ornithine-urea cycle, and immunological surveillance. Arginase-I is predominant in cytosol, and arginase-II is localised in the mitochondria.
Mishra Suman, Mishra Rajnikant
doaj   +1 more source

Frequent adaptive immune responses against arginase-1

OncoImmunology, 2018
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite, Rasmus Erik Johansson Mortensen, Morten Hansen, Morten Orebo Holmström, Shamaila Munir Ahmad, Nicolai Grønne Dahlager Jørgensen, Özcan Met, Marco Donia, Inge Marie Svane, Mads Hald Andersen   +9 more
doaj   +1 more source