Results 21 to 30 of about 39,646 (166)
Scientifica, 2016 Arginase regulates arginine metabolism, ornithine-urea cycle, and immunological surveillance. Arginase-I is predominant in cytosol, and arginase-II is localised in the mitochondria.
Mishra Suman, Mishra Rajnikant
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Arginase in glomerulonephritis [PDF]
Kidney International, 2002 l-Arginine is converted to nitric oxide and citrulline by the enzyme nitric oxide synthase (NOS). Its in vivo inhibition has led to the revelation of a multitude of diverse, often conflicting functions in the inflammatory melee. l-Arginine is also converted to ornithine and urea by the enzyme arginase as a part of the hepatic urea cycle.
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Frequent adaptive immune responses against arginase-1
OncoImmunology, 2018 The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite +9 more
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Evaluation of optimal conditions for arginase activity in streptozotocin induced diabetic rats
Veterinární Medicína, 2005 The assay conditions needed to achieve maximal activity of liver and kidney arginase in diabetic and non-diabetic rats were investigated and compared.
M. Erisir, E. Ercel, S. Yilmaz, S. Ozan
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Arginase and pulmonary diseases [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 2008 Recent studies have indicated that arginase, which converts L-arginine into L-ornithine and urea, may play an important role in the pathogenesis of various pulmonary disorders. In asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis, increased arginase activity in the airways may contribute to obstruction and hyperresponsiveness of ...
Maarsingh, Harm +2 more
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Pathogens, 2022 Arginase is a metalloenzyme that plays a central role in Leishmania infections. Previously, rosmarinic and caffeic acids were described as antileishmanial agents and as Leishmania amazonensis arginase inhibitors.
Julio Abel Alfredo dos Santos Simone Come +6 more
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Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II
Cellular Physiology and Biochemistry, 2016 Background/Aims: Despite significant advancements in the diagnosis and treatment of osteosarcoma, the overall survival has remained relatively unchanged for over two decades.
Bhuvana A. Setty +5 more
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Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise
Microorganisms, 2021 Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in humans worldwide. Because a vaccine is not available and the currently small number of existing drugs are less than ideal due to lack of specificity and emerging
Nicola S. Carter +7 more
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Antileishmanial Activity of 4,8-Dimethoxynaphthalenyl Chalcones on Leishmania amazonensis
Antibiotics, 2022 Leishmaniasis is a neglected tropical disease caused by Leishmania species. Available therapeutic options have several limitations. The drive to develop new, more potent, and selective antileishmanial agents is thus a major goal.
Kaio Maciel de Santiago-Silva +13 more
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Frontiers in Immunology, 2021 COVID-19 ranges from asymptomatic in 35% of cases to severe in 20% of patients. Differences in the type and degree of inflammation appear to determine the severity of the disease.
Matthew J. Dean +32 more
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