Results 21 to 30 of about 50,915 (302)

Age-related alteration of arginase activity impacts on severity of leishmaniasis. [PDF]

, 2008
BACKGROUND: The leishmaniases are a group of vector-borne parasitic diseases that represent a major international public health problem; they belong to the most neglected tropical diseases and have one of the highest rates of morbidity and mortality. The
Asrat Hailu, Choi, B., Abebe, T, Munder, Markus, Choi, B-S, Abebe Tamrat, Modolell, M, Choi Beak-San, Manuel Modolell, Hailu, A, Abebe, T., Fuentes, J., Modolell Manuel, Kropf Pascale, Abebe, Tamrat, Munder, M, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Modolell, M., Munder, M., Kropf, P., Kropf, Pascale, Beak-San Choi, Hailu, A., Fuentes, Jose M, Munder Markus, Fuentes Jose M., Pascale Kropf, Muller, I, Fuentes, JM, Jose M. Fuentes, Müller Ingrid, Jose M Fuentes, Hailu Asrat, Choi, Beak-San, Hailu, Asrat, Modolell, Manuel, Müller, I., Tamrat Abebe   +40 more
core   +2 more sources

L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes

Frontiers in Pharmacology, 2020
Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease. One of the early signs of T2DM associated cardiovascular events is the development of vascular dysfunction.
Alia Shatanawi, Munther S. Momani, Ruaa Al-Aqtash, Mohammad H Hamdan, Mohammad H Hamdan, Munir N. Gharaibeh   +5 more
doaj   +1 more source

Large-Scale Tissue Microarray Evaluation Corroborates High Specificity of High-Level Arginase-1 Immunostaining for Hepatocellular Carcinoma

Diagnostics, 2021
Arginase-1 catalyzes the conversion of arginine to ornithine and urea. Because of its predominant expression in hepatocytes, it serves as a marker for hepatocellular carcinoma, although other tumor entities can also express arginase-1. To comprehensively
Maximilian Lennartz, Eva Gehrig, Sören Weidemann, Natalia Gorbokon, Anne Menz, Franziska Büscheck, Claudia Hube-Magg, Andrea Hinsch, Viktor Reiswich, Doris Höflmayer, Christoph Fraune, Frank Jacobsen, Christian Bernreuther, Patrick Lebok, Guido Sauter, Waldemar Wilczak, Stefan Steurer, Eike Burandt, Andreas H. Marx, Ronald Simon, Till Krech, Till S. Clauditz, Sarah Minner, David Dum, Ria Uhlig   +24 more
doaj   +1 more source

Arginine depletion as a mechanism for the immune privilege of corneal allografts. [PDF]

, 2011
The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model.
Larkin, Daniel FP, George, Andrew J.T., Fu, Hongmei, Coe, D, Hongmei Fu, Chai, J-G, Zaher, S, David Coe, George, Andrew JT, Fu, H, Khan, A, Larkin, Daniel F.P., Jian-Guo Chai, Ingrid Müller, Kropf, P, Müller, Ingrid, Kropf, Pascale, Larkin, DFP, George, AJT, Adnan Khan, Khan, Adnan, Zaher, Sarah, Daniel F. P. Larkin, Mueller, I, Pascale Kropf, Coe, David, Sarah Zaher, Andrew J. T. George, Chai, Jian-Guo   +28 more
core   +1 more source

Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma

Journal of Hematology & Oncology, 2008
Background L-arginine is the common substrate for the two isoforms of arginase. Arginase I, highly expressed in the liver and arginase II mainly expressed in the kidney.
Patterson John R, Metoyer Toye, Caldas Yupanqui A, Vonderhaar Derek J, Tate David J, Aviles Diego H, Zea Arnold H   +6 more
doaj   +1 more source

The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages

Veterinary Sciences, 2022
Immunosuppressive myeloid cells in the tumor microenvironment play a major role in suppressing tumor immunity via the production of arginase, IL-10, and others.
Aimee M. Soileau, Cally N. Quick, Cambri E. Moeller, Jessica C. Schaumburg, Sita S. Withers   +4 more
doaj   +1 more source

Crystallization of Arginase [PDF]

Nature, 1946
ATTEMPTS to obtain arginase in a pure state were only partly successful and resulted in an approximately twenty-fold purification of the enzyme from liver extracts1,2,3.
openaire   +2 more sources

L-arginine deprivation impairs Leishmania major-specific T-cell responses. [PDF]

, 2009
The amino acid L-arginine plays a crucial role in the regulation of immune responses. We have recently shown that uncontrolled replication of Leishmania parasites at the site of pathology correlates with high levels of arginase activity in nonhealing ...
Markus Munder, Beak‐San Choi, Munder, Markus, Kropf, Pascale, Choi, Beak-San, Rogers, Matthew, Matthew Rogers, Pascale Kropf   +7 more
core   +1 more source

ARGINASE ACTIVITY IN BREAST CANCER: IS IT A SIGNIFICANT BIOMARKER? [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2009
Due to the importance of arginase enzyme in different malignant disorders, the purpose ofthe present study was to determine and compare the arginase activity in cancerous cells andtheir normal and benign counterparts.
Doaa Maximous, Madeha Zakhary, Manal Mandour, Sahar El-Said, Amal Mahmoud   +4 more
doaj   +1 more source

Arginase in glomerulonephritis [PDF]

Kidney International, 2002
l-Arginine is converted to nitric oxide and citrulline by the enzyme nitric oxide synthase (NOS). Its in vivo inhibition has led to the revelation of a multitude of diverse, often conflicting functions in the inflammatory melee. l-Arginine is also converted to ornithine and urea by the enzyme arginase as a part of the hepatic urea cycle.
openaire   +2 more sources