Results 31 to 40 of about 5,976,322 (209)

Arginine depletion as a mechanism for the immune privilege of corneal allografts. [PDF]

, 2011
The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model.
Larkin, Daniel FP, George, Andrew J.T., Fu, Hongmei, Coe, D, Hongmei Fu, Chai, J-G, Zaher, S, David Coe, George, Andrew JT, Fu, H, Khan, A, Larkin, Daniel F.P., Jian-Guo Chai, Ingrid Müller, Kropf, P, Müller, Ingrid, Kropf, Pascale, Larkin, DFP, George, AJT, Adnan Khan, Khan, Adnan, Zaher, Sarah, Daniel F. P. Larkin, Mueller, I, Pascale Kropf, Coe, David, Sarah Zaher, Andrew J. T. George, Chai, Jian-Guo   +28 more
core   +1 more source

Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion. [PDF]

, 2013
Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase.
Hundemer, Michael, Voss, R-H, Sergej Medenhoff, Voss Ralf-Holger, Goldschmidt, Hartmut, Knies, D, Anthony D Ho, Voss, Ralf-Holger, Knies Diana, Engelhardt, Melanie, Wabnitz, Guido, Knies, Diana, Michael Hundemer, Diana Knies, Yvonne Samstag, Munder, M, Feldmeyer, N, Samstag, Y, Theobald, Matthias, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Conradi Roland, Nadja Feldmeyer, Luckner-Minden, Claudia, Conradi, R, Roland Conradi, Mueller, I, Pascale Kropf, Matthias Theobald, Wabnitz, G, Conradi, Roland, Ho, AD, Müller Ingrid, Goldschmidt Hartmut, Hundemer Michael, Hundemer, M, Medenhoff, Sergej, Claudia Luckner-Minden, Luckner-Minden Claudia, Wabnitz Guido, Engelhardt, M, Samstag, Yvonne, Munder, Markus, Guido Wabnitz, Feldmeyer, Nadja, Theobald, M, Feldmeyer Nadja, Engelhardt Melanie, Medenhoff Sergej, Kropf Pascale, Hartmut Goldschmidt, Theobald Matthias, Ho, Anthony D, Medenhoff, S, Ralf-Holger Voss, Goldschmidt, H, Kropf, Pascale, Munder Markus, Ho Anthony D., Samstag Yvonne, Melanie Engelhardt, Luckner-Minden, C   +63 more
core   +2 more sources

Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice

BMC Immunology, 2009
Background Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice.
Rothenberg Marc E, Wills-Karp Marsha, O'Brien William E, Cederbaum Stephen D, Hajek Amanda R, Collier Ann R, Niese Kathryn A, Zimmermann Nives   +7 more
doaj   +1 more source

Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline

BMC Cardiovascular Disorders, 2009
Background Pharmacological inhibition of endothelial arginase-II has been shown to improve endothelial nitric oxide synthase (eNOS) function and reduce atherogenesis in animal models.
Ruffieux Jean, Carvas João, Rajapakse Angana, Ming Xiu-Fen, Yang Zhihong   +4 more
doaj   +1 more source

Study of the effect of acetylsalicylic acid and a selective arginase II inhibitor KUD 975 on the correction of hemostatic disorders in experimental preeclampsia [PDF]

Research Results in Pharmacology, 2022
Introduction: The disruption of the functional state of the vascular endothelium is among the main causes of preeclampsia, which is one of the most common causes of maternal and perinatal mortality.
Anastasia V. Gureeva, Olga V. Severinova, Vladimir V. Gureev, Indira S. Kochkarova, Elena V. Avdeyeva   +4 more
doaj   +3 more sources

Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling [PDF]

, 2020
Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of
Kayluz Frias Boligan, Yu, Yi, Hunger, Robert E., Frias Boligan, Kayluz, Ladeiras, Diogo, Gunten, Stephan, Xiu‐Fen Ming, Stephan von Gunten, Ming, Xiu-Fen, Diogo Ladeiras, Yuyan Xiong, Ming, Xiu‐Fen, Xiujie Liang, Zhihong Yang, Boligan, Kayluz Frias, Liang, Xiujie, Yi Yu, Robert E. Hunger, Xiong, Yuyan, Yang, Zhihong, von Gunten, Stephan, Boligan KF, Liang X, von Gunten S, Xiong Y, Ming XF, Yu Y, Ladeiras D, Yang Z, Hunger RE   +29 more
core   +1 more source

Rat liver arginase system under acetaminophen-induced toxic injury and protein deprivation [PDF]

The Ukrainian Biochemical Journal, 2017
Arginase activity and L-arginine content in both cytosolic and mitochondrial fractions of rat liver cells under the conditions of toxic injury on the background of protein deprivation was studied.
H. P. Kopylchuk, I. M. Nykolaichuk, O. M. Zhuretska   +2 more
doaj   +1 more source

Unique hepatic cytosolic arginase evolved independently in ureogenic freshwater air-breathing teleost, Heteropneustes fossilis. [PDF]

PLoS ONE, 2013
Hepatic cytosolic arginase (ARG I), an enzyme of the urea cycle operating in the liver of ureotelic animals, is reported to be present in an ammoniotelic freshwater air-breathing teleost, Heteropneustes fossilis which has ureogenic potential.
Shilpee Srivastava, B K Ratha
doaj   +1 more source

rIFN-γ-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition

Journal of Translational Medicine, 2003
Background Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-γ (rIFN-γ), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC).
Gallardo Stacie T, Melicharová Karolina, Patenia Rebecca, Hu Wei, Melichar Bohuslav, Freedman Ralph   +5 more
doaj   +1 more source

STUDYING DOSE-DEPENDENT ENDOTHELIO- AND CARDIOPROTECTIVE ACTIVITY OF SELECTIVE ARGINASE II INHIBITOR IN HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION [PDF]

Research Results in Pharmacology, 2016
This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction.
Vladimir Yakushev, Nikolaj Filippenko, Irina Kizilova, Mikhail Korokin, Evgeniya Beskhmelnitsyna, Anna Litvinova   +5 more
doaj   +3 more sources