Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. [PDF]
Physiol Rep, 2018 We have previously shown that hypoxia‐induced proliferation of human pulmonary microvascular endothelial cells (hPMVEC) depends on arginase II, and that epidermal growth factor receptor (EGFR) is necessary for hypoxic‐induction of arginase II.
Pool CM, Jin Y, Chen B, Liu Y, Nelin LD.
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Hypoxia-induced proliferation of HeLa cells depends on epidermal growth factor receptor-mediated arginase II induction. [PDF]
Physiol Rep, 2017 Solid tumors can often be hypoxic in regions, and cancer cells can respond to hypoxia with an increase in proliferation and a decrease in apoptosis, leading to a net increase in viable cell numbers.
Setty BA +5 more
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Arginase II inhibition prevents nitrate tolerance. [PDF]
Br J Pharmacol, 2012 BACKGROUND AND PURPOSENitrate tolerance, the loss of vascular responsiveness with continued use of nitrates, remains incompletely understood and is a limitation of these therapeutic agents. Vascular superoxide, generated by uncoupled endothelial NOS (eNOS), may play a role. As arginase competes with eNOS for L‐arginine and may exacerbate the production
Khong SM +10 more
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Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs. [PDF]
Exp Mol Med, 2018 Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that is involved in the ...
Koo BH +8 more
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Immunostimulated Arginase II Expression in Intestinal Epithelial Cells Reduces Nitric Oxide Production and Apoptosis. [PDF]
Front Cell Dev Biol, 2017 Increased production of nitric oxide (NO) and subsequent local cytotoxicity to mucosal epithelial cells has been proposed as a putative mechanism involved in the development of necrotizing enterocolitis (NEC).
Talavera MM +5 more
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Arginase-II negatively regulates renal aquaporin-2 and water reabsorption.
FASEB J, 2018 Type‐II L‐arginine:ureahydrolase, arginase‐II (Arg‐II), is abundantly expressed in the kidney. The physiologic role played by Arg‐II in the kidney remains unknown.
Huang J +5 more
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Correction of morphofunctional disorders with asialoerythropoietin and selective inhibitor of arginase II KUD975 in cases of ischemic kidney damage in the experiment [PDF]
Research Results in Pharmacology, 2018 Introduction: Acute kidney injury (AKI), which is based on ischemic-reperfusion damage, is a widespread life-threatening condition and remains a serious public health problem with a high mortality rate among patients.
Vladislav Elagin +2 more
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Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity [PDF]
Frontiers in Physiology, 2016 Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L-arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase-II (Arg-II) in ...
Ji Huang +6 more
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Involvement of increased arginase-1 group 2 innate lymphoid cells and myeloid-derived suppressor cells in endometrial carcinoma: A pilot study [PDF]
Journal of International Medical ResearchBackground Endometrial carcinoma is a prevalent gynecologic malignancy with a relatively low survival rate. Emerging studies have demonstrated that crosstalk between group 2 innate lymphoid cells (ILC2s) and myeloid-derived suppressor cells drives tumor ...
Zhangyun Gong +12 more
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Кубанский научный медицинский вестник, 2019 The aim of the present work was to study the pharmacological activity of a low-molecular arginase II selective inhibitor (low-molecular compound with laboratory code ZB49) with the chemical formula 2-{1-[3-(3-[chloroisoxazole-5-yl) propyl] piperidin-4-yl}
Liliya V. Korokina +4 more
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