Results 21 to 30 of about 5,976,322 (209)

Role of Arginase 2 as a potential pharmacological target for the creation of new drugs to correct cardiovascular diseases [PDF]

Research Results in Pharmacology, 2020
Introduction: The review provides relevant information about arginase 2, the role of this enzyme in the formation of endothelial dysfunction and, as a consequence, the development of cardiovascular diseases.
Sergey A. Demchenko, Ivan S. Koklin, Natalia Yu. Koklina   +2 more
doaj   +3 more sources

Correction of morphofunctional disorders of the cardiovascular system with asialized erythropoietin and arginase II selective inhibitors KUD 974 and KUD 259 in experimental preeclampsia [PDF]

Research Results in Pharmacology, 2020
Introduction: Preeclampsia remains one of the most common causes of maternal and perinatal mortality worldwide. A significant role in the pathogenesis of this pathology is assigned to placental ischemia and endothelial dysfunction.
Tatyana I. Lokteva, l’ya S. Rozhkov, Vladimir V. Gureev, Anastasia V. Gureeva, Marija A. Zatolokina, Elena V. Avdeeva, Lyudmila A. Zhilinkova, Evgenij E. Prohoda, Elizoveta O. Yarceva   +8 more
doaj   +3 more sources

Proteomic identification of mitochondrial targets of arginase in human breast cancer. [PDF]

PLoS ONE, 2013
We have previously reported arginase expression in human breast cancer cells and demonstrated that the inhibition of arginase by N(ω) hydroxy L-arginine (NOHA) in MDA-MB-468 cells induces apoptosis. However, arginase expression and its possible molecular
Rajan Singh, Nuraly K Avliyakulov, Melissa Braga, Michael J Haykinson, Luis Martinez, Vikash Singh, Meher Parveen, Gautam Chaudhuri, Shehla Pervin   +8 more
doaj   +1 more source

Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia. [PDF]

, 2013
The underlying mechanisms resulting in the profound immune suppression characteristic of human visceral leishmaniasis (VL) are not fully understood. Here, we tested the hypothesis that arginase, an enzyme associated with immunosuppression, is higher in ...
Corset, C, Cloke Tom, Closs Ellen, Cloke, T, Yifru Sisay, Abebe Tamrat, Corset, M, Modolell, M, Takele, Yegnasew, Corware, Karina, Cloke, Tom, Sisay Yifru, Hailu, Workagegnehu, Munder, M, Tacchini-Cottier, F, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Weldegebreal, T, Weldegebreal Teklu, Teklu Weldegebreal, Closs, E, Sisay, Y, Hailu, W, Mueller, I, Pascale Kropf, Camille Corset, Müller Ingrid, Sisay, Yifru, Takele Yegnasew, Closs, Ellen, Karina Corware, Weldegebreal, Teklu, Modolell, Manuel, Corware, K, Asrat Hailu, Corware Karina, Abebe, T, Corset Margaux, Munder, Markus, Manuel Modolell, Hailu Workagegnehu, Hailu, A, Margaux Corset, Modolell Manuel, Workagegnehu Hailu, Kropf Pascale, Abebe, Tamrat, Tacchini-Cottier, Fabienne, Fabienne Tacchini-Cottier, Yegnasew Takele, Kropf, Pascale, Corset Camille, Munder Markus, Tom Cloke, Corset, Margaux, Ellen Closs, Tacchini-Cottier Fabienne, Hailu Asrat, Corset, Camille, Hailu, Asrat, Takele, Y, Tamrat Abebe, Closs, E., Abebe, T., Corset, C., Takele, Y., Sisay, Y., Hailu, A., Müller, I., Weldegebreal, T., Corset, M., Corware, K., Cloke, T., Modolell, M., Munder, M., Kropf, P., Tacchini-Cottier, F., Hailu, W.   +79 more
core   +1 more source

Arginase from kiwifruit: properties and seasonal variation [PDF]

, 1997
The in vitro activity of arginase (EC 3.5.3.1) was investigated in youngest-mature leaves and roots (1-3 mm diameter) of kiwifruit vines (Actinidia deliciosa var. deliciosa) during an annual growth cycle, and enzyme from root material partially purified.
Petach, Helen H., C. A. Hale, C. J. Clark, H. H. Petach, Clark, Christopher J., Daniel, Roy M., R. M. Daniel, Hale, C.A.   +7 more
core   +1 more source

Endothelial arginase II and atherosclerosis. [PDF]

Korean J Anesthesiol, 2011
Atherosclerotic vascular disease is the leading cause of morbidity and mortality in developed countries. While it is a complex condition resulting from numerous genetic and environmental factors, it is well recognized that oxidized low-density ...
Ryoo S, Berkowitz DE, Lim HK.
europepmc   +2 more sources

Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma

Journal of Hematology & Oncology, 2008
Background L-arginine is the common substrate for the two isoforms of arginase. Arginase I, highly expressed in the liver and arginase II mainly expressed in the kidney.
Patterson John R, Metoyer Toye, Caldas Yupanqui A, Vonderhaar Derek J, Tate David J, Aviles Diego H, Zea Arnold H   +6 more
doaj   +1 more source

Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia. [PDF]

, 2012
BACKGROUND: Cutaneous leishmaniasis is a vector-borne disease that is in Ethiopia mainly caused by the parasite Leishmania aethiopica. This neglected tropical disease is common in rural areas and causes serious morbidity.
Cloke, T, Abebe Tamrat, Mekonen Woinshet, Modolell, M, Thomas Cloke, Woldeyes Mihretu, Seich Al Basatena, Nafisa-Katrin, Abebe, T., Corware, Karina, Bilcha, K, Seich al Basatena, N., Munder, M, Lionel Fry, Tacchini-Cottier, F, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Bilcha, K., Fry Lionel, Seich Al Basatena, N.K., Cloke Thomas, Hailu, A., Cloke, Thomas, Mueller, I, Mihretu Woldeyes, Pascale Kropf, Müller Ingrid, Mekonen, Woinshet, Karina Corware, Modolell, Manuel, al Basatena, N-KS, Müller, I., Woldeyes, M, Woinshet Mekonen, Corware, K, Asrat Hailu, Kassahun Bilcha, Corware Karina, Abebe, T, Woldeyes, Mihretu, Munder, Markus, Manuel Modolell, Mekonen, W., Hailu, A, Modolell Manuel, Fry, Lionel, Kropf Pascale, Abebe, Tamrat, Fry, L., Fry, L, Corware, K., Cloke, T., Modolell, M., Munder, M., Tacchini-Cottier, Fabienne, Fabienne Tacchini-Cottier, Kropf, P., Kropf, Pascale, Bilcha, Kassahun, Tacchini-Cottier, F., Woldeyes, M., Munder Markus, Nafisa-Katrin Seich Al Basatena, Mekonen, W, Tacchini-Cottier Fabienne, Hailu Asrat, Hailu, Asrat, Tamrat Abebe, Bilcha Kassahun, Seich al Basatena Nafisa-Katrin   +70 more
core   +1 more source

Age-related alteration of arginase activity impacts on severity of leishmaniasis. [PDF]

, 2008
BACKGROUND: The leishmaniases are a group of vector-borne parasitic diseases that represent a major international public health problem; they belong to the most neglected tropical diseases and have one of the highest rates of morbidity and mortality. The
Asrat Hailu, Choi, B., Abebe, T, Munder, Markus, Choi, B-S, Abebe Tamrat, Modolell, M, Choi Beak-San, Manuel Modolell, Hailu, A, Abebe, T., Fuentes, J., Modolell Manuel, Kropf Pascale, Abebe, Tamrat, Munder, M, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Modolell, M., Munder, M., Kropf, P., Kropf, Pascale, Beak-San Choi, Hailu, A., Fuentes, Jose M, Munder Markus, Fuentes Jose M., Pascale Kropf, Muller, I, Fuentes, JM, Jose M. Fuentes, Müller Ingrid, Jose M Fuentes, Hailu Asrat, Choi, Beak-San, Hailu, Asrat, Modolell, Manuel, Müller, I., Tamrat Abebe   +40 more
core   +2 more sources

Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. [PDF]

PLoS ONE, 2010
Increased catabolism of arginine by arginase is increasingly viewed as an important pathophysiological factor in cardiovascular disease, including atherosclerosis induced by high cholesterol diets.
Aaron Erdely, Diane Kepka-Lenhart, Rebecca Salmen-Muniz, Rebecca Chapman, Tracy Hulderman, Michael Kashon, Petia P Simeonova, Sidney M Morris   +7 more
doaj   +1 more source