Results 21 to 30 of about 5,115,447 (250)

Aging Increases Hypoxia-Induced Endothelial Permeability and Blood-Brain Barrier Dysfunction by Upregulating Arginase-II. [PDF]

Aging Dis
Increased endothelial permeability plays an important role in blood-brain barrier (BBB) dysfunction and is implicated in neuronal injury in many diseased conditions. BBB disruption is primarily determined by dysfunction of endothelial cell-cell junctions.
Cheng X, Potenza DM, Brenna A, Ajalbert G, Yang Z, Ming XF.   +5 more
europepmc   +2 more sources

Arginase II Plays a Central Role in the Sexual Dimorphism of Arginine Metabolism in C57BL/6 Mice. [PDF]

J Nutr, 2020
BACKGROUND Sex differences in plasma concentration of arginine and arginase activity of different tissues have been reported in mice. In addition, male but not female C57BL/6 mice have a dietary arginine requirement for growth.
Mohammad MA, Didelija IC, Marini JC.
europepmc   +2 more sources

Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging

bioRxiv
Aging is a predominant risk factor for heart disease. Aging heart reveals low-grade chronic inflammation, cell apoptosis, cardiac fibrosis, and increased vulnerability to ischemic injury.
Potenza DM, Cheng X, Ajalbert G, Brenna A, Giraud M, Frobert A, Cook S, Mertz KD, Yang Z, Ming X.   +9 more
europepmc   +2 more sources

Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis. [PDF]

Cell Death Dis, 2018
Type-II L-arginine:ureahydrolase, arginase-II (Arg-II), is shown to activate mechanistic target of rapamycin complex 1 (mTORC1) pathway and contributes to cell senescence and apoptosis.
Yu Y, Xiong Y, Montani JP, Yang Z, Ming XF.   +4 more
europepmc   +2 more sources

Arginase II: atherogenesis beyond enzyme activity. [PDF]

J Am Heart Assoc, 2013
It is now well established that endothelial cells (EC) and vascular smooth muscle cells (VSMC) are two specialized and interacting components of the vascular wall that orchestrate the pathogenesis of atherosclerosis through complex signaling cascades.
Pandey D, Romer L, Berkowitz DE.
europepmc   +4 more sources

Arginase II activity regulates cytosolic Ca²⁺ level in a p32-dependent manner that contributes to Ca²⁺-dependent vasoconstriction in native low-density lipoprotein-stimulated vascular smooth muscle cells. [PDF]

Exp Mol Med, 2019
Although arginase II (ArgII) is abundant in mitochondria, Ca2+-accumulating organelles, the relationship between ArgII activity and Ca2+ translocation into mitochondria and the regulation of cytosolic Ca2+ signaling are completely unknown.
Koo BH, Hong D, Hong HD, Lim HK, Hoe KL, Won MH, Kim YM, Berkowitz DE, Ryoo S.   +8 more
europepmc   +2 more sources

Correction of morphofunctional disorders of the cardiovascular system with asialized erythropoietin and arginase II selective inhibitors KUD 974 and KUD 259 in experimental preeclampsia [PDF]

Research Results in Pharmacology, 2020
Introduction: Preeclampsia remains one of the most common causes of maternal and perinatal mortality worldwide. A significant role in the pathogenesis of this pathology is assigned to placental ischemia and endothelial dysfunction.
Tatyana I. Lokteva, l’ya S. Rozhkov, Vladimir V. Gureev, Anastasia V. Gureeva, Marija A. Zatolokina, Elena V. Avdeeva, Lyudmila A. Zhilinkova, Evgenij E. Prohoda, Elizoveta O. Yarceva   +8 more
doaj   +4 more sources

Assessment of Arginase II with Biochemical Changes in Patients with Chronic Kidney Disease

Medical Journal of Babylon
Background:Chronic kidney disease (CKD) is defined as the presence of kidney damage or an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 mt2, persisting for 3 months or more, irrespective of the cause.
Dunia Abbas Khudhair, Hadeel Luay Kareem, Mohmmed Ali Yaseen, Hussam A. Mohammed   +3 more
doaj   +2 more sources

CARDIOVASCULAR EFFECTS OF AN ARGINASE II SELECTIVE INHIBITOR [PDF]

Research Results in Pharmacology, 2016
For the first time in vitro experiments there were studied the inhibitory activity and safety of potential molecules arginase II selective inhibitors from the group of norleucine derivatives.
Vladimir Yakushev, Mikhail Pokrovskii
doaj   +7 more sources

Protective Role of Arginase II in Cerebral Ischemia and Excitotoxicity. [PDF]

J Neurol Neurosci, 2016
Arginase (Arg), one of the enzymes involved in the urea cycle, provides an essential route for the disposal of excess nitrogen resulting from amino acid and nucleotide metabolism. Two reported subtypes of Arg (ArgI and II) compete with nitric oxide synthase (NOS) to use L-arginine as a substrate, and subsequently regulate NOS activity.
Ahmad AS, Shah ZA, Doré S.
europepmc   +4 more sources