Assessment of Arginase II with Biochemical Changes in Patients with Chronic Kidney Disease
Medical Journal of BabylonBackground:Chronic kidney disease (CKD) is defined as the presence of kidney damage or an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 mt2, persisting for 3 months or more, irrespective of the cause.
Mohmmed Ali Yaseen +3 more
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Poly (ADP-Ribose) Polymerase 1 Mediated Arginase II Activation Is Responsible for Oxidized LDL-Induced Endothelial Dysfunction. [PDF]
Front Pharmacol, 2018 It is well known that arginase II leads to decreased synthesis of nitric oxide (NO) by competing with endothelial nitric oxide synthase (eNOS) for their same substrate L-arginine.
Wang Q +9 more
europepmc +2 more sources
Role of tubular epithelial arginase-II in renal inflammaging. [PDF]
NPJ Aging Mech Dis, 2021 The aging kidney undergoes complex changes and is vulnerable to injury and development of chronic kidney disease (CKD) with preponderance affecting more women than men.
Huang J +5 more
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Role of Arginase-II in Podocyte Injury under Hypoxic Conditions. [PDF]
Biomolecules, 2022 Hypoxia plays a crucial role in acute and chronic renal injury, which is attributable to renal tubular and glomerular cell damage. Some studies provide evidence that hypoxia-dependent upregulation of the mitochondrial enzyme arginase type-II (Arg-II) in ...
Ren Z +6 more
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L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells. [PDF]
Pulm Circ, 2021 The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Douglass MS +3 more
europepmc +2 more sources
Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32-Dependent Manner. [PDF]
J Am Heart Assoc, 2018 Background Arginase II activity contributes to reciprocal regulation of endothelial nitric oxide synthase (eNOS). We tested the hypotheses that arginase II activity participates in the regulation of Ca2+/Ca2+/calmodulin‐dependent kinase II/eNOS ...
Koo BH +10 more
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Arginase-II Deficiency Extends Lifespan in Mice. [PDF]
Front Physiol, 2017 The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66Shc and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-
Xiong Y +4 more
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Arginase-II negatively regulates renal aquaporin-2 and water reabsorption.
FASEB J, 2018 Type-II l-arginine:ureahydrolase, arginase-II (Arg-II), is abundantly expressed in the kidney. The physiologic role played by Arg-II in the kidney remains unknown.
Huang J +5 more
europepmc +3 more sources
Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production. [PDF]
PLoS ONE, 2012 Consumption of L-arginine contributes to reduced bioavailability of nitric oxide (NO) that is critical for the development of ischemia-reperfusion injury.
Adrian T Gonon +7 more
doaj +1 more source
Sciences of Phytochemistry, 2023 This study aimed to explore the phytochemical profile, heavy metal composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens due to its folkloric acclaimed aphrodisiac use.
Enoch Buba Badgal +2 more
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