Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II [PDF]
Cellular Physiology and Biochemistry, 2016 Background/Aims: Despite significant advancements in the diagnosis and treatment of osteosarcoma, the overall survival has remained relatively unchanged for over two decades.
Bhuvana A. Setty +5 more
doaj +4 more sources
Role of pulmonary epithelial arginase-II in activation of fibroblasts and lung inflammaging. [PDF]
Aging Cell, 2023 Elevated arginases including type‐I (Arg‐I) and type‐II isoenzyme (Arg‐II) are reported to play a role in aging, age‐associated organ inflammaging, and fibrosis. A role of arginase in pulmonary aging and underlying mechanisms are not explored.
Zhu C +7 more
europepmc +2 more sources
Elevation of Arginase-II in Podocytes Contributes to Age-Associated Albuminuria in Male Mice. [PDF]
Int J Mol Sci, 2023 One of the manifestations of renal aging is podocyte dysfunction and loss, which are associated with proteinuria and glomerulosclerosis. Studies show a male bias in glomerular dysfunction and chronic kidney diseases, and the underlying mechanisms remain ...
Ajalbert G +4 more
europepmc +2 more sources
Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II. [PDF]
Int J Mol Sci, 2023 The increase of vascular arginase activity during aging causes endothelial dysfunction. This enzyme competes with the endothelial nitric oxide synthase (eNOS) for L-arginine substrate.
Serna E +8 more
europepmc +2 more sources
Paracrine Effects of Renal Proximal Tubular Epithelial Cells on Podocyte Injury under Hypoxic Conditions Are Mediated by Arginase-II and TGF-β1. [PDF]
Int J Mol Sci, 2023 Hypoxia is an important risk for renal disease. The mitochondrial enzyme arginase-II (Arg-II) is expressed and/or induced by hypoxia in proximal tubular epithelial cells (PTECs) and in podocytes, leading to cellular damage.
Ma Y +6 more
europepmc +2 more sources
Arginase II protein regulates Parkin-dependent p32 degradation that contributes to Ca2+-dependent eNOS activation in endothelial cells. [PDF]
Cardiovasc Res, 2022 Aims Arginase II (ArgII) plays a key role in the regulation of Ca2+ between the cytosol and mitochondria in a p32-dependent manner. p32 contributes to endothelial nitric oxide synthase (eNOS) activation through the Ca2+/CaMKII/AMPK/p38MAPK/Akt signalling
Koo BH, Won MH, Kim YM, Ryoo S.
europepmc +2 more sources
Hypoxia Induces Renal Epithelial Injury and Activates Fibrotic Signaling Through Up-Regulation of Arginase-II. [PDF]
Front Physiol, 2021 The ureohydrolase, type-II arginase (Arg-II), is a mitochondrial enzyme metabolizing L-arginine into urea and L-ornithine and is highly expressed in renal proximal tubular cells (PTC) and upregulated by renal ischemia.
Liang X +7 more
europepmc +2 more sources
Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-κB Pathway. [PDF]
Front Cell Dev Biol, 2021 Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of low back pain (LBP), which imposes massive clinical and socioeconomic burdens.
Li F +17 more
europepmc +2 more sources
Arginase-II promotes melanoma and lung cancer cell growth by regulating Sirt3-mtROS axis. [PDF]
Front Cell Dev BiolBackground Aberrant mitochondrial metabolism is a key source of massive mitochondrial reactive oxygen species (mtROS) in tumour cells. Arginase-II (Arg-II), a widely expressed mitochondrial metabolic enzyme, has recently been shown to enhance mtROS ...
Yang Y +6 more
europepmc +2 more sources
Arginase-II gene deficiency reduces skeletal muscle aging in mice. [PDF]
Aging (Albany NY)Age-associated sarcopenia decreases mobility and is promoted by cell senescence, inflammation, and fibrosis. The mitochondrial enzyme arginase-II (Arg-II) plays a causal role in aging and age-associated diseases.
Caretti M +6 more
europepmc +2 more sources