Results 211 to 220 of about 50,915 (302)

Extracellular Vesicles Delivered a Functional ARG1 Enzyme and Restored Its Activity in a Mouse Model of ARG1-D Resulting in Improved Lifespan. [PDF]

Int J Mol Sci
Hsieh LE, Cacciottolo M, LeClaire MJ, Morrison W, Murphy B, Lau C, Elliott K, Marban L, Sun M.   +8 more
europepmc   +1 more source

The Role of Noncoding RNA in MGMT‐Positive Glioblastoma: A Narrative Review

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary malignant tumor of the central nervous system and is characterized by rapid progression, frequent recurrence, and poor survival outcomes. The current standard of care, comprising maximal safe surgical resection followed by radiotherapy with concomitant and adjuvant temozolomide (TMZ), has ...
Junfeng Zhao, Jiaxuan Chen, Yingrui Bai, Ying Li, Yiming Han, Chuankun Han, Yintao Li   +6 more
wiley   +1 more source

Multifaceted roles of arginine in cellular function, signaling, and disease. [PDF]

Front Chem
Mehmood T, Ali M, Javed M, Mateen RM, Nouman M, Knani S, Alreshidi R, Iqbal S.   +7 more
europepmc   +1 more source

Expression of COL6A1 in Tumor Matrix of Cholangiocarcinoma and Its Mechanism of Tumor Progression

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Cholangiocarcinoma (CCA), a malignant tumor originating from the bile duct epithelial cells, is characterized by aggressive invasion and poor prognosis. Abnormal remodeling of the tumor microenvironment plays a pivotal role in its disease progression.
Weibin Zhang, Chongshi Gao, Chongzhou Lan, Jia Dong, Boxing Xu, Yingmei Li, Jin Dai, Baitong Che, Cheng Li, Gang Dong, Yunfei Wu, Bo Li, Cheng Yang, Lingmei Kong   +13 more
wiley   +1 more source

Nuclear Medicine Tracers Targeting Tumor-Associated Macrophages. [PDF]

Pharmaceutics
Shi D, Mao W, Xie Y, Zhou P, Hu M, Liu Y, Cheng D.   +6 more
europepmc   +1 more source

Amyloid‐Forming Amylin Secreted by the Pancreas Promotes Hypoxia‐Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Human amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Alice E. Knapton, Nirmal Verma, Deepak Kotiya, Alice P. Sowton, Benjamin D. Thackray, Lorenz M. W. Holzner, Paula M. Darwin, Sanda Despa, Florin Despa, Andrew J. Murray   +9 more
wiley   +1 more source

Repurposing of Clomiphene Citrate and Its Antileishmanial and Antifungal Activities: <i>In Silico</i> and <i>In Vitro</i> Studies. [PDF]

Biomolecules
Santos LJDC, Abi-Chacra ÉA, de Carvalho RCV, França LM, do Nascimento DA, Carvalho FAA, Zazeri G, Carvalho ALM.   +7 more
europepmc   +1 more source

Macrophage lipid efflux regulates the tumour microenvironment in early‐stage lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Macrophages undergo metabolic rewiring even during early tumourigenesis. 2. Main alterations of macrophages are conserved between human and mice in early‐stage lung adenocarcinoma. 3. Tumour‐associated macrophages are characterised by enhanced lipid efflux 4.
Yujie Zheng, Yuan Wang, Yalin Wang, Yue Shi, Hui Kong, Shaohua Lu, Yong Zhang, Jie Hu, Jian Zhou, Xiangdong Wang, Meng Xiang, Qiong Liu, Hongyi Xin, Charles A. Powell, Fred R. Hirsch, Chunxue Bai, Yuanlin Song, Jun Yin, Dawei Yang   +18 more
wiley   +1 more source

<i>Candida</i> spp. suppress neutrophil reactive nitrogen species to evade killing. [PDF]

mBio
Burgess TB, Hammond FR, Szkuta PT, Lewis A, Christou S, Bowden KA, Bicanic T, Prince LR, Ayscough KR, Partridge DG, Johnston SA, Condliffe AM, Elks PM.   +12 more
europepmc   +1 more source