Results 211 to 220 of about 5,115,447 (250)

Activities of arginase I and II are limiting for endothelial cell proliferation

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2002
Polyamines are essential for cell proliferation; therefore, we hypothesized that arginase I or arginase II activities, via production of ornithine for polyamine synthesis, may be limiting for proliferation of endothelial cells (EC). Bovine coronary venular EC stably transfected with a lacZ gene (lacZ-EC, control), rat arginase I cDNA (AI-EC), or mouse ...
Hui, Li, Cynthia J, Meininger, Katherine A, Kelly, James R, Hawker, Sidney M, Morris, Guoyao, Wu   +5 more
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Cloning and Characterization of the Mouse and Rat Type II Arginase Genes

Molecular Genetics and Metabolism, 1998
Two forms of arginase, both catalyzing the hydrolysis of arginine to ornithine and urea, are found in animals ranging from amphibians to mammals. In humans, inherited deficiency of hepatic or type I arginase results in hyperargininemia, a syndrome characterized by periodic episodes of hyperammonemia, spasticity, and neurological deterioration. In these
R K, Iyer, J M, Bando, C P, Jenkinson, J G, Vockley, P S, Kim, R M, Kern, S D, Cederbaum, W W, Grody   +7 more
openaire   +2 more sources

Induction of arginase II in livers of bile duct-ligated rats

Biochemical Pharmacology, 2002
Nitric oxide (NO) has been implicated in playing a role in liver cirrhosis, but the regulatory mechanisms are still unclear. As arginase shares a common substrate with NO synthase (NOS), the aim of this study was to investigate the expression of arginase I and II in cirrhotic liver. Liver cirrhosis was induced in rats by chronic bile duct ligation (BDL)
Chang-Li, Wei, Wei-Min, Hon, Kang-Hoe, Lee, Masataka, Mori, Tomomi, Gotoh, Hoon-Eng, Khoo   +5 more
openaire   +2 more sources

The role of arginase I and II in the vasculature

2017
The work presented in this thesis focuses on the enzyme arginase, and the role it plays in regulating NO bioavailability in the vasculature as well as in the progression of atherosclerosis. The interest in this work was sparked by previous work done in our laboratory and others showing the ability of arginase, an enzyme well known for its role in the ...
openaire   +1 more source

Increased expression of arginase I and II in allergic nasal mucosa

The Laryngoscope, 2011
Abstract Objectives/Hypothesis: It is known that arginase may be a regulator of diverse pathways, including production of nitric oxide (NO). Increased expression of arginase has been reported in several inflammatory lung diseases, including allergic asthma, suggesting that this may be a common ...
Woo Sung, Cho, Tae Hoon, Kim, Ki Hyoung, Kim, Heung Man, Lee, Seung Hoon, Lee, Young Ho, Ju, Euy Hyun, Park, Kang Woo, Kim, Sang Hag, Lee   +8 more
openaire   +2 more sources

Regulation of arginase expression by T-helper II cytokines and isoproterenol

Surgery, 2004
Trauma causes a release of catecholamines, transforming growth factor-beta (TGF-beta), and T-helper II cytokines (TH2). Individually, these substances also induce arginase in macrophages. The purpose of this study was to determine the synergistic interactions between isoproterenol, TGF-beta, and TH2 cytokines on arginase expression in macrophages ...
Andrew R, Barksdale, Andrew C, Bernard, Mary E, Maley, Gloria L, Gellin, Paul A, Kearney, Bernard R, Boulanger, Betty J, Tsuei, Juan B, Ochoa   +7 more
openaire   +2 more sources

Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability

European Journal of Clinical Pharmacology, 2021
Gustavo H Oliveira-Paula, F. Coeli-Lacchini, L. P. Ferezin, Graziele C. Ferreira, Lucas C. Pinheiro, Waynice N. Paula-Garcia, L. V. Garcia, J. Tanus-Santos, R. Lacchini   +8 more
semanticscholar   +1 more source

Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?

Hypertension Research, 2020
V. López, E. Uribe, F. Moraga
semanticscholar   +1 more source

Arginase-II Promotes Tumor Necrosis Factor-α Release From Pancreatic Acinar Cells Causing β-Cell Apoptosis in Aging

Diabetes, 2017
Yuyan Xiong, Gautham Yepuri, Sevil Necetin, J. Montani, X. Ming, Zhihong Yang   +5 more
semanticscholar   +1 more source

BINDING MOLECULES TO ARGINASE II [ARG2]

2021
ADDYMAN ALEXANDRA, AUSTIN MARK, BARNARD MICHELLE, CERUNDOLO VINCENZO, CHAN DENICE, DIAMANDAKIS AGATA, FIEDLER SEBASTIAN, GROVES MARIA, HAYNES STUART, HOLT SARAH, JENKINSON LESLEY, KESWICK STEPHANIE, MCLAUGHLIN FIONA, SHARMA POOJA, SHIBATA YOKO, SLATER LOUISE, WHITEHOUSE JESSICA, CARR MARK D, BURSCHOWSKY DANIEL, SEEWOORUTHUN CHITRA   +19 more
openaire   +2 more sources