Results 111 to 120 of about 805,592 (386)

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

ACS Chemical Biology, 2016
Protein arginine methyltransferases (PRMTs) play a crucial role in a variety of biological processes. Overexpression of PRMTs has been implicated in various human diseases including cancer.
M. Eram, Yudao Shen, Magdalena M. Szewczyk, Hong Wu, G. Senisterra, Fengling Li, Kyle V. Butler, H. U. Kaniskan, B. A. Speed, C. D. Seña, A. Dong, H. Zeng, M. Schapira, M. Schapira, P. Brown, C. Arrowsmith, C. Arrowsmith, D. Barsyte-Lovejoy, Jing Liu, M. Vedadi, M. Vedadi, Jian Jin   +21 more
semanticscholar   +1 more source

A reappraisal of nitrogen-to-protein conversion factors in cassava roots. [S10-05] [PDF]

, 2012
A study was conducted comparing the amino acid profiles of 10 commercial varieties (COL) and 15 clones with the highest levels of nitrogen (HIN) over two years of harvests. The highest nitrogen values detected in roots to date are close to 1.30%.
Ceballos, Hernan, Dufour, Dominique, Hershey, Clair, Morante, Nelson, Morel, Gilles, Reynes, Max, Ricci, Julien, Sanchez, Teresa   +7 more
core  

ArgR is an essential local transcriptional regulator of the arcABC-operon in Streptococcus suis and crucial for biological fitness in acidic environment [PDF]

, 2011
Streptococcus suis is one of the most important pathogens in pigs and can also cause severe infections in humans. Despite its clinical relevance very little is known about the factors contributing to its virulence.
Benga, L., Fulde, M., Goethe, R., Greeff, A., de, Smith, H.E., Valentin-Weigand, P., Willenborg, J.   +6 more
core   +2 more sources

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Arginine-deprivation–induced oxidative damage sterilizes Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Tuberculosis results in over 1.7 million deaths annually; this problem is worsened by the emergence of drug-resistant strains. New drugs and a better understanding of the mechanisms of existing interventions are needed to prevent the ...
S. Tiwari, Andries J. van Tonder, C. Vilchèze, Vítor Mendes, S. E. Thomas, Adel Malek, Bing Chen, Mei Chen, John Kim, T. Blundell, J. Parkhill, Brian Weinrick, Michael Berney, W. Jacobs   +13 more
semanticscholar   +1 more source

The Pharmacodynamics of L-Arginine [PDF]

The Journal of Nutrition, 2007
L-arginine is a precursor for nitric oxide (NO) synthesis. NO is a ubiquitous mediator that is formed by a family of enzymes named NO synthases. In the brain, NO acts as a neurotransmitter; in the immune system, NO acts as a mediator of host defense; and in the cardiovascular system, NO mediates the protective effects of the intact endothelium, acting ...
openaire   +4 more sources

The cell cycle program of polypeptide labeling in Chlamydomonas reinhardtii [PDF]

, 1977
The cell cycle program of polypeptide labeling in syndhronous cultures of wild-type Chlamydomonas reinhardtii was analyzed by pulse-labeling cells with 35SO4 = or [3H]arginine at different cell cycle stages.
Hill, Kim R., Howell, Stephen H., Posakony, James W.   +2 more
core   +5 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Arginine and nitrate tolerance [PDF]

British Journal of Pharmacology, 2000
Organic nitrates remain in widespread use as NO donors for the treatment of coronary artery disease and chronic heart failure, where dilator effects on capacitance veins and conduit arteries contribute to their therapeutic efficacy. Tolerance to the dilator effects of nitrates remains a persisting therapeutic problem, often occurring within 24 h of ...
openaire   +3 more sources

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source