Results 121 to 130 of about 458,229 (307)
The twin arginine translocation pathway in Escherichia coli : mechanism and quality control [PDF]
The bacterial twin-arginine translocation (Tat) pathway has the unique ability to export pre-folded proteins across the cytoplasmic membrane. Its name came from the almost invariant twin-arginine motif in the signal peptide of Tat substrates ...
Ren, Chao, Ph.D.
core
Arginase from kiwifruit: properties and seasonal variation
, 1997 The in vitro activity of arginase (EC 3.5.3.1) was investigated in youngest-mature leaves and roots (1-3 mm diameter) of kiwifruit vines (Actinidia deliciosa var. deliciosa) during an annual growth cycle, and enzyme from root material partially purified.
Petach, Helen H. +7 more
core +1 more source
The estimation of arginine [PDF]
Biochemical Journal, 1956 H, ROSENBERG, A H, ENNOR, J F, MORRISON
openaire +2 more sources
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Pyruvoyl dependent arginine decarboxylases from Chlamydiae and Crenarchaea
, 2008 textArginine decarboxylase is a key enzyme involved in the polyamine pathway of organisms. Pyruvoyl-dependent arginine decarboxylases are expressed in the form of proenzymes that self-cleave to form N-terminal [beta] and C-terminal [alpha] subunits ...
Giles, Teresa Neelima
core
Advanced Science, EarlyView.We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha +13 more
wiley +1 more source
Arginine-induced currents in TbAAT5-3-expressing oocytes in the presence or absence of Na+ and K+.
, 2017 Oocytes were clamped at -80 mV. Inward currents were recorded upon superfusion of H2O-injected oocytes (A) and TbAAT5-1 injected oocytes (B) with Na+-Ringer containing 50 μM arginine at pH 7.4 (B).
Ehud Inbar (437174) +12 more
core +1 more source
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Mechanisms of l-Arginine-Auxotrophic Response and Their Cancer Therapeutic Implications
, 2016 l-arginine (Arg) is a semi-essential amino acid. Because there is no specific storage system for the cellular l-Arg pool, Arg needs to be de novo synthesized or directly acquired from an extracellular source to meet physiological need.
Lynn G. Feun +9 more
core +1 more source