Results 111 to 120 of about 458,229 (307)
Advanced Science, EarlyView.Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance +17 more
wiley +1 more source
A structural investigation of bacterial twin-arginine translocation (tat) complexes by single-particle electron microscopy [PDF]
The Twin arginine translocase (Tat) pathway was first characterised in chloroplast thylakoid membranes in the late 1990s. It has since been identified in the plasma membranes of both Gram-positive and Gram-negative bacteria.
Beck, Daniel K.
core
Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing
The successful treatment of diabetic wounds requires strategies that promote anti-inflammation, angiogenesis, and re-epithelialization of the wound.
Yan Yang (33204) +9 more
core +1 more source
Advanced Science, EarlyView.Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu +12 more
wiley +1 more source
Protein Arginine Allylation and Subsequent Fluorophore Targeting
, 2013 Protein Arginine Allylation and Subsequent Fluorophore ...
Pan, Yanbo +6 more
core +1 more source
Hederagenin promotes SIRT6 to attenuate epidural scar formation by aggravating PRMT1 deacetylation
Bone & Joint ResearchAims: The formation of a postoperative epidural scar induced by epidural fibrosis is the main reason for recurrence of lumbar disc herniation after laminectomy.
Xiao-Chen Fan, Jue Wang
doaj +1 more source
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Advanced Science, EarlyView.Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
Assembly and mechanism of bacterial twin-arginine translocation systems [PDF]
The bacterial twin-arginine translocation (Tat) pathway is able to export pre-folded cofactor containing proteins across the cytoplasmic membrane. Tat substrates bear cleavable N-terminal signal peptides that are characterized by the presence of a ...
Baglieri, J.
core
Recently, we reported the synthesis of a hydrophilic aldehyde-functional methacrylic polymer (Angew. Chem., 2021, 60, 12032–12037). Herein we demonstrate that such polymers can be reacted with arginine in aqueous solution to produce arginine-functional ...
George Sanderson (16615561) +6 more
core +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source