Results 121 to 130 of about 843,121 (388)
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Arginine-deprivation–induced oxidative damage sterilizes Mycobacterium tuberculosis
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Tuberculosis results in over 1.7 million deaths annually; this problem is worsened by the emergence of drug-resistant strains. New drugs and a better understanding of the mechanisms of existing interventions are needed to prevent the ...
S. Tiwari +13 more
semanticscholar +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Frontiers in Immunology, 2018 Lysinuric protein intolerance (LPI) is a recessively inherited aminoaciduria caused by mutations of SLC7A7, the gene encoding y+LAT1 light chain of system y+L for cationic amino acid transport. The pathogenesis of LPI is still unknown.
Bianca Maria Rotoli +8 more
doaj +1 more source
Synthesis and properties of lipoamino acid/fatty acid mixtures. Influence of the amphiphilic structure. [PDF]
, 2009 The acylation of amino acids by acid chlorides with from 8 to 12 carbon atoms, in alkaline aqueous medium following Shotten-Baumann reaction, results in sodium salts of Nα-acylamino acids and fatty acids mixture. These lastest are present in proportion
Alric, Isabelle +4 more
core +2 more sources
Arginine and nitrate tolerance [PDF]
British Journal of Pharmacology, 2000 Organic nitrates remain in widespread use as NO donors for the treatment of coronary artery disease and chronic heart failure, where dilator effects on capacitance veins and conduit arteries contribute to their therapeutic efficacy. Tolerance to the dilator effects of nitrates remains a persisting therapeutic problem, often occurring within 24 h of ...
openaire +3 more sources
Advanced Biology, EarlyView.Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers +3 more
wiley +1 more source
LIN28B Promotes Cancer Cell Dissemination and Angiogenesis
Advanced Biology, EarlyView.Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo +8 more
wiley +1 more source
Studies on the Metabolism of Arginine and Histidine [PDF]
, 1925 Corbet Page Stewart
openalex +3 more sources
A micromethod for the determination of glycocyamine in biological fluids and tissue extracts [PDF]
, 1941 In the two following communications (1, 2) evidence is presented that glycocyamine is a normal precursor of creatine in the animal body. These studies required a satisfactory micromethod for the determination of glycocyamine.
Borsook, Henry, Dubnoff, Jacob W.
core