Results 161 to 170 of about 458,229 (307)

Definitions of arginine availability: a critical metabolic marker of physiological processes. [PDF]

Front Endocrinol (Lausanne)
Tosur M, Jahoor F, Balasubramanyam A.
europepmc   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Organisation and mechanism of bacterial twin arginine translocases [PDF]

The bacterial Tat pathway facilitates the translocation of pre-folded proteins over the cytoplasmic membrane. In Gram-negative bacteria, TatA, TatB and TatC (each an integral membrane protein) are the essential components.
Barnett, James Paul
core  

A pharmacodynamic study of rapid lactate metabolic modulation by intravenous L-arginine in brain metastases. [PDF]

Front Oncol
Liu X, Du G, Mu N, He L.
europepmc   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

The role of L-Arginine metabolism in the hallmarks of cancer as an emerging pathway to drug design. [PDF]

Front Pharmacol
Garcia-Valdez G, Vazquez-Galvan AE, Gonzalez-Llerena JL, Treviño-Almaguer D, Gallegos-Ibarra DL, Guajardo-Gonzalez D, Balderas-Renteria I, Camacho-Corona MDR, Espinosa-Rodriguez BA.   +8 more
europepmc   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Fatty acids-based compounds as novel prophylaxis or treatment for oropharyngeal <i>Neisseria gonorrhoeae:</i> an <i>in vitro</i> study. [PDF]

Emerg Microbes Infect
Hamza SA, Paolini R, Moore C, Unemo M, Yap T, McCullough M, Mayfosh A, Rau T, Kleid S, Hocking JS, Kong FY, Celentano A.   +11 more
europepmc   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Arginine-containing desensitizing toothpaste for the treatment of dentin hypersensitivity: a meta-analysis

, 2016
Zheng-yan Yang,1,2 Fei Wang,1,2 Keke Lu,1,2 Yue-heng Li,1,2 Zhi Zhou1,2 1Department of Preventive Dentistry, The College of Stomatology, 2Department of Preventive Dentistry, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing,
Yang ZY, Lu K, Wang F, Li YH, Zhou Z
core