Results 181 to 190 of about 388,707 (260)

The competition of amino acid among tumors, tumor-associated macrophages and T cells based on metabolic reprogramming. [PDF]

iScience
Xianyu C, Song Y, Zhao C, Min Q, Wang Z, Zhang M, Zhang B.   +6 more
europepmc   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Dynamic metabolomics of uterine fluid of laying hens: Key metabolites and pathways governing sperm motility and functional longevity. [PDF]

Poult Sci
Zhang Q, Du H, Ge C, Zhang Z, Yuan J, Li Y, Isa AM, Chen J, Sun Y.   +8 more
europepmc   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Amino Acid-Driven Mitochondrial Metabolic Rewiring Controls Antitumor Immunity. [PDF]

Cancers (Basel)
Ham S, Jo MJ, Song KH, Choi BH.
europepmc   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Vespakinin-M delineates an AMPK/mTOR-arginine-TCA cycle axis to act as an immunometabolic switch in post-stroke microglia. [PDF]

Redox Biol
Wang D, Zhang J, Zhuang Z, Wang Q, Li J, Wang X, Li K, Liu Y, Cao Y, Li L, Zhang Y, Zhao Y, Zhao Y, Zhao H, Zhang C.   +14 more
europepmc   +1 more source

Arginin [PDF]

, 2017
openaire   +1 more source

Mechanical Intelligence in Bone Regeneration: Bridging Material and Cellular Memory for Enhanced Healing

Advanced Science, EarlyView.
Mechanical intelligence reframes bone regeneration as a time‐dependent coupling between material and cellular memory. Biomaterials store and release mechanical history, while cells retain prior cues and remodel the repair niche. Matching these memories to healing stages may guide stage‐specific scaffolds, sensing‐assisted prediction, mechanical dosing,
Jin Tian, Guoyou Huang, Yang Chen, Teng Ma, Bo Cheng, Feng Xu, XiaoKang Li, Pei Yang, Ting Wen   +8 more
wiley   +1 more source

Interactions and Conformational Plasticity of Human Uncoupling Protein 1 in Response to Small-Molecule Analogues: Insights from Molecular Dynamics Simulations. [PDF]

ACS Omega
Rathod S, Jagtap UA, Pankhania F, Shukla R, Paul AT.   +4 more
europepmc   +1 more source