Results 111 to 120 of about 41,836 (256)

Acute Stress Attenuates Hepatic Ischemia–Reperfusion Injury via Hypothalamic CRH Neuron‐Induced HPA Axis Activation

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This study demonstrates the protective effect of acute restraint stress (ARS) against hepatic ischemia–reperfusion injury (HIRI) in mice and investigates its specific neuroendocrine mechanisms. During ARS, excitability of PVNCRH neurons significantly increases, which drives HPA axis to release corticosterone, thereby reducing hepatic inflammation and ...
Xiaoqi Lin, Dan Yang, Shuyang Wang, Baoshan Wang, Ling Zhu, Yanyu Zhou, Yifei Zhou, Song Zhang, Qionghui Zhan, Yingfu Jiao, Weifeng Yu, Liqun Yang, Po Gao   +12 more
wiley   +1 more source

Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration [PDF]

, 2014
Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated ...
A Tidholm, BD Rose, CC Horn, CL Limebeer, DC Dale, DM Vail, E Portillo, EM Rock, G Jang, GK Ogilvie, GK Ogilvie, GP Chrousos, GR Morrow, H Imamura, Hannah Kenward, IK Vonderen van, J Ito, J Loor, JD Chen, Jonathan Elliott, K Barabas, K Olsson, KL Koch, L Kelland, LA Parker, LA Parker, Ludovic Pelligand, LX Cubeddu, LX Cubeddu, M Boer-Dennert de, M Fredrikson, M Minami, MK Samson, MS Kim, N Percie du Sert, N Percie du Sert, PL Andrews, PL Andrews, PL Andrews, RD Fisher, S Ina, S Robery, SD Caras, T Bloom, V Napadow, VA Puente-Redondo de la, X Yu   +46 more
core   +3 more sources

DSOK‐0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity‐Based Anorexia Model

International Journal of Eating Disorders, Volume 59, Issue 1, Page 54-69, January 2026.
ABSTRACT Objective Anorexia nervosa (AN) is a metabolic‐psychiatric disorder characterized by severe weight loss, hypercortisolemia, and hypothalamic–pituitary–adrenal (HPA) axis activation. In this study, we investigated the effect of inhibiting cortisol regeneration via the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) on the ...
Hiroki Kawai, Nanami Wada, Shinji Sakamoto, Kenji Miyazaki, Taro Kato, Yoshihiro Horiuchi, Hiroshi Kirii, Hoang Duy Nguyen, Kenji Hinotsu, Yoshio Ohya, Takahiro Asada, Akiyoshi Yokode, Yuko Okahisa, Haruko Miyazaki, Toshitaka Oohashi, Manabu Takaki   +15 more
wiley   +1 more source

Modulating Neurotoxic Effects of Prenatal Chlorpyrifos Exposure Through Probiotic and Vitamin D Gestational Supplementation: Unexpected Effects on Neurodevelopment and Sociability

Food Frontiers, Volume 7, Issue 1, January 2026.
This study investigates whether gestational probiotic and vitamin D supplementation can mitigate CPF effects in Wistar rats. While supplementation did not reverse CPF‐induced deficits, it induced notable neurodevelopmental changes in control animals, underscoring the need for further research on prenatal supplementation safety.
Mario Coca, Cristian Perez‐Fernandez, Ana C. Abreu, Ana M. Salmerón, Miguel Morales‐Navas, Diego Ruiz‐Sobremazas, Teresa Colomina, Ignacio Fernández, Fernando Sanchez‐Santed   +8 more
wiley   +1 more source

Systematic Review of Literature on Single-Nucleotide Polymorphisms Within the Oxytocin and Vasopressin Receptor Genes in the Development of Social Cognition Dysfunctions in Individuals Suffering From Autism Spectrum Disorder

Frontiers in Psychiatry, 2019
Introduction: Autism spectrum disorder (ASD) is found in virtually all population groups regardless of ethnic or socioeconomic backgrounds. Among others, dominant symptoms of autism persistent throughout its course of development include, inter alia ...
Krzysztof Maria Wilczyński, Krzysztof Maria Wilczyński, Andrzej Siwiec, Małgorzata Janas-Kozik, Małgorzata Janas-Kozik   +4 more
doaj   +1 more source

Tolvaptan: A Novel Diuretic in Heart Failure Management

Journal of Tehran University Heart Center, 2016
Heart failure (HF) is still a major problem worldwide with high morbidity and mortality rates. The recently developed medication for HF is still incapable of reducing its morbidity and mortality, and clinical data supporting the efficacy and safety of ...
Hilman Zulkifli Amin, Siska Suridanda Danny   +1 more
doaj  

Genetic analysis of nephrogenic diabetes insipidus patients: A study on the Iranian population

Molecular Genetics & Genomic Medicine
Introduction Nephrogenic diabetes insipidus (NDI) is a rare genetic disease that causes water imbalance. The kidneys play a crucial role in regulating body fluids by controlling water balance through urine excretion.
Saeed Ghasemi, Marzieh Mojbafan, Saeed Talebi, Nakysa Hooman, Rozita Hoseini   +4 more
doaj   +1 more source

A Case of Congenital Nephrogenic Diabetes Insipidus Caused by Thr108Met Variant of Aquaporin 2

Frontiers in Pediatrics, 2020
Congenital nephrogenic diabetes insipidus (CNDI) is a rare renal disorder caused by mutations in arginine vasopressin receptor 2 (AVPR2) or aquaporin 2 (AQP2). The clinical signs of CNDI include polyuria, compensatory polydipsia, dehydration, electrolyte
Lina Ma, Lina Ma, Dengyan Wu, Dengyan Wu, Xingmin Wang, Xingmin Wang, Yonghong Yang, Yonghong Yang   +7 more
doaj   +1 more source

The novel desmopressin analogue [V4Q5]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models [PDF]

, 2015
Desmopressin (dDAVP) is a safe haemostatic agent with previously reported antitumour activity. It acts as a selective agonist for the V2 vasopressin membrane receptor (V2r) present on tumour cells and microvasculature.
Alonso, Daniel Fernando, Garona, Juan, Gomez, Daniel Eduardo, Iannucci, Nancy Beatriz, Orlando, Ulises Daniel, Ortega, Hugo Hector, Pastrian, María Belén, Pifano, Marina, Podesta, Ernesto Jorge, Ripoll, Giselle Vanina   +9 more
core   +1 more source

Tolvaptan treatment for severe neonatal autosomal-dominant polycystic kidney disease

Pediatric nephrology (Berlin, West), 2017
BackgroundSevere neonatal autosomal-dominant polycystic kidney disease (ADPKD) is rare and easily confused with recessive PKD. Managing such infants is difficult and often unsuccessful.Case diagnosis/treatmentA female infant with massive renal ...
R. Gilbert, H. Evans, K. Olalekan, A. Nagra, Mushfequr R. Haq, M. Griffiths   +5 more
semanticscholar   +1 more source